ID A0A144QDD5_9GAMM Unreviewed; 541 AA.
AC A0A144QDD5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Small-conductance mechanosensitive channel {ECO:0000256|RuleBase:RU369025};
DE Flags: Precursor;
GN ORFNames=A3K91_2680 {ECO:0000313|EMBL:AMT98247.1};
OS Psychrobacter alimentarius.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=261164 {ECO:0000313|EMBL:AMT98247.1, ECO:0000313|Proteomes:UP000076104};
RN [1] {ECO:0000313|EMBL:AMT98247.1, ECO:0000313|Proteomes:UP000076104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAMC 27889 {ECO:0000313|EMBL:AMT98247.1,
RC ECO:0000313|Proteomes:UP000076104};
RA Lee J., Kim O.-S.;
RT "Genome sequencing of Psychrobacter alimentarius PAMC 27889.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mechanosensitive channel that participates in the regulation
CC of osmotic pressure changes within the cell, opening in response to
CC stretch forces in the membrane lipid bilayer, without the need for
CC other proteins. Contributes to normal resistance to hypoosmotic shock.
CC Forms an ion channel of 1.0 nanosiemens conductance with a slight
CC preference for anions. {ECO:0000256|RuleBase:RU369025}.
CC -!- SUBUNIT: Homoheptamer. {ECO:0000256|RuleBase:RU369025}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU369025}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369025}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017, ECO:0000256|RuleBase:RU369025}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369025}.
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DR EMBL; CP014945; AMT98247.1; -; Genomic_DNA.
DR RefSeq; WP_062845723.1; NZ_CP014945.1.
DR AlphaFoldDB; A0A144QDD5; -.
DR STRING; 261164.A3K91_2680; -.
DR KEGG; pali:A3K91_2680; -.
DR PATRIC; fig|261164.3.peg.2805; -.
DR OrthoDB; 9793781at2; -.
DR Proteomes; UP000076104; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.1340.30; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR007055; BON_dom.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR045275; MscS_archaea/bacteria_type.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30221; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR PANTHER; PTHR30221:SF1; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR Pfam; PF04972; BON; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS50914; BON; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU369025};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|RuleBase:RU369025};
KW Ion transport {ECO:0000256|RuleBase:RU369025};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369025};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369025};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369025}; Transport {ECO:0000256|RuleBase:RU369025}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..541
FT /note="Small-conductance mechanosensitive channel"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007517870"
FT TRANSMEM 186..205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369025"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369025"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369025"
FT DOMAIN 97..163
FT /note="BON"
FT /evidence="ECO:0000259|PROSITE:PS50914"
FT REGION 55..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 59381 MW; ACEBD73B9BDCE780 CRC64;
MAAYLDHSII RSCLKTWGQA WLLLIVICWL PAHAAGEDVG SITTALGVET TEEVATDDST
TSANEIAESS EPLRAPPVIN GQSTNNAQIE TTPSLQTDSD IRQRIKGIFS EIEGLQAVNV
SVAQGVVTLT GETPNEKKAQ QAINLTNRLT DVVTVDDRID RTLDVQDNVT TVYQTLKAQV
KNLVKALPLL LVGLVIFILV TWLGSWLSNR KKMWQRLTPN PFVAELLAQT VKVIFIIFGL
ILALSLIGAE TILGTLLGGA GVIGIAVGFA VKDTIENYIA SLMLSIRQPF RARDHILINQ
QEGIVVRLTS RATILMTLDG NQLRIPNAEV FKGTILNYTK NPERRFTFEL GVDANNDPLA
AIKVGIDAIN DLIFVLDNPK AMAVITNVGD SNIVLEFQIW VNQSETDFAK ARSIAIRETK
HALENAGFSL PEPIYRLRFN KKLEKALEHM QGSLDTSSAT AHKPRVSATP IITHDDHDEV
PSIDDKDKQK AKARAKQILQ GHDAKEVLDA RPNDKLMEKV EQEIAESSDE TDLLDSASPQ
E
//
