ID A0A145Q4J0_9BACT Unreviewed; 810 AA.
AC A0A145Q4J0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=GEMMAAP_13770 {ECO:0000313|EMBL:AMW06861.1};
OS Gemmatimonas phototrophica.
OC Bacteria; Gemmatimonadota; Gemmatimonadetes; Gemmatimonadales;
OC Gemmatimonadaceae; Gemmatimonas.
OX NCBI_TaxID=1379270 {ECO:0000313|EMBL:AMW06861.1, ECO:0000313|Proteomes:UP000076404};
RN [1] {ECO:0000313|EMBL:AMW06861.1, ECO:0000313|Proteomes:UP000076404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP64 {ECO:0000313|EMBL:AMW06861.1,
RC ECO:0000313|Proteomes:UP000076404};
RX PubMed=24821787; DOI=10.1073/pnas.1400295111;
RA Zeng Y., Feng F., Medova H., Dean J., Koblizek M.;
RT "Functional type 2 photosynthetic reaction centers found in the rare
RT bacterial phylum Gemmatimonadetes.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:7795-7800(2014).
RN [2] {ECO:0000313|EMBL:AMW06861.1, ECO:0000313|Proteomes:UP000076404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP64 {ECO:0000313|EMBL:AMW06861.1,
RC ECO:0000313|Proteomes:UP000076404};
RX PubMed=26636755; DOI=10.1111/1758-2229.12363;
RA Zeng Y., Baumbach J., Barbosa E.G., Azevedo V., Zhang C., Koblizek M.;
RT "Metagenomic evidence for the presence of phototrophic Gemmatimonadetes
RT bacteria in diverse environments.";
RL Environ. Microbiol. Rep. 8:139-149(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP011454; AMW06861.1; -; Genomic_DNA.
DR RefSeq; WP_075071674.1; NZ_CP011454.1.
DR AlphaFoldDB; A0A145Q4J0; -.
DR STRING; 1379270.GEMMAAP_13770; -.
DR GeneID; 78445192; -.
DR KEGG; gph:GEMMAAP_13770; -.
DR eggNOG; COG0188; Bacteria.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000076404; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 4.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000076404};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 12..470
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 810 AA; 87700 MW; 1F4889ACBCA79B49 CRC64;
MPTPRRERVM PREVTDEMRD SFINYSMSVI TSRALPDVRD GLKPVNRRIL YAMNELGLAP
GRPFKKAATV VGDVLGKYHP HGDSSVYDAL VRMVQDFSLR YPLIEGQGNF GSIDGDPAAA
YRYTEARMAA PGVALLEGID QNTVDFVPNY DDRLQEPSVL PAAIPNLLVN GVSGIAVGMA
TNMPPHNLRE IGKAIIRVIE EPSVDLSELR KIVKGPDFPT AGLIVGKEAI KQYMETGRGR
LINRARVVLE AKPGSSRAQL VVTELPYQAN KARIIEQIAD LVKEEKLVGI SALRDESDRE
GLRMVIELKR DAEPKKLLER LFKLTGLETT FGVINLTLVP EHGRLVPREL GLRALIDHFI
AHRHDVLVKR SEFEKSKAEA RLHIVEGLLI AVNDIDRIVQ LIKTAKDVEQ AQARLRKEYA
LSEIQANAIL ALRLAKLTGL EVTALKTEAK ELKARIKELM TLLANPAMRM AALAEEVAQI
VDRFGDARRT EIVTAEAAAE VAETVADAEV VGVVTYGGRV LQAPLPSGRA RKTDAAERDL
PLDELPMVRG RLRQTESMLV LSQDGQAYSI LGGELPPAAR SGRGTPLKDV VEWPRQGAPV
LGAIVRDFSH PLFVTMVTAT GQVKRTVIKE FKNARLAGIK AIRLDKGDRI IGAGITSGQD
DLVLATALGQ VIRFHESDVR DMGRDAGGVR GITLKDFDRV VAMAVVGPQQ EVCVGTSAGY
VKRVAVEAIP LQGRGGQGVQ MVAAAEKAGS VVGLVPVTVE AAASFITGAG TSVAADLQEL
PIVGRAIKAT QLSEWPGGMT SVGFVATSDE
//
