ID   A0A146GAN6_TERSA        Unreviewed;       864 AA.
AC   A0A146GAN6;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:GAT34689.1};
GN   ORFNames=TSACC_23121 {ECO:0000313|EMBL:GAT34689.1};
OS   Terrimicrobium sacchariphilum.
OC   Bacteria; Verrucomicrobiota; Terrimicrobiia; Terrimicrobiales;
OC   Terrimicrobiaceae; Terrimicrobium.
OX   NCBI_TaxID=690879 {ECO:0000313|EMBL:GAT34689.1, ECO:0000313|Proteomes:UP000076023};
RN   [1] {ECO:0000313|Proteomes:UP000076023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NM-5 {ECO:0000313|Proteomes:UP000076023};
RA   Qiu Y., Matsuura N., Ohashi A., Tourlousse M.D., Sekiguchi Y.;
RT   "Draft genome sequence of Terrimicrobium sacchariphilum strain NM-5.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000076023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NM-5 {ECO:0000313|Proteomes:UP000076023};
RA   Qiu Y.-L., Tourlousse D.M., Matsuura N., Ohashi A., Sekiguchi Y.;
RT   "Draft genome sequence of Terrimicrobium sacchariphilum NM-5(T), a
RT   facultative anaerobic soil bacterium of the class Spartobacteria.";
RL   Genome Announc. 0:0-0(2017).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAT34689.1}.
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DR   EMBL; BDCO01000002; GAT34689.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A146GAN6; -.
DR   STRING; 690879.TSACC_23121; -.
DR   InParanoid; A0A146GAN6; -.
DR   OrthoDB; 1049785at2; -.
DR   Proteomes; UP000076023; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          312..385
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   864 AA;  96350 MW;  E0AD7637BD3FAD36 CRC64;
     MTDKKHIKSC ILHKILISAY SLDINFTFQT LTAVNSSRPI FHLLPNAHLD PVWLWDWREG
     LNEGLATVQS VLNLMDEFPQ LTFIRGESAI YEHVEKTSPA LFRRIARQVE EGRWDIVGGT
     HIQPDSNLAS TETLCRQFEY GLDYFRSRFG THPTVAWQAD SFGHTPGWPN ILHAFGMTDF
     TFTRPQRGQF PLDTPAFWWK GSHGNRLLCY RQHWPWYCSE RANLPEILDL TQKESSGFGF
     RNIGILMGLG NHGGGPSRRH ILEVEKWREQ HPEIEVRYST LHGFFRALHS EIDDHPESDV
     PTVNGDLGYC LRGCYSSVQK FKTLYRQAES AVTEAECTAA LVEQAFDVPA RPLEEAWKAV
     LFNAFHDILP GSSIERAVEE QSAWMGLALH HAQEARFAAL NELASRIDTS VAAPALPDHP
     TAVPMLVWNS QPHPFHGLVE IETSVDYRPI YSYENRADEV PLSVHDSRGR NLPLQSISTE
     HTSMPHLPWR KRVLVPLTIP PWGWHVVRFA WDELSSPSLP GGSPALTGRA GSTGITNGDW
     TIHHAEDSLR IERNGLNFWN TGRDISLQVV EDPWGSWGGM NEEVDSYQLD KVRETWRLTA
     SEVIETGPLR AKLWTRWEGK NSWITLTFSL EQDSPVVKVD ARLLWNERSA RLKLVLPCSG
     DMEFDVPGAT IHRASAGQLP SGRWVRRGTG GGAAGFASTA LSDIDFSSDE LRITLARATR
     YANDVPTGPE EFPWQPAVDC GELKFAFSLF SSDIAPDSAA SALLHPPVAQ MVHAHQGDLS
     SLGSLGQMKP EGVRVLSLQK LPTGEVFARI QNRNDHTCHA TVEVSGGAGN ASNLLPQEIR
     TIAIVPTAAI HRPREAAATA VSAA
//