ID A0A150AF75_9BACT Unreviewed; 614 AA.
AC A0A150AF75;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Cobalamin biosynthesis protein CbiG {ECO:0000313|EMBL:KXX68392.1};
GN ORFNames=AVL50_21735 {ECO:0000313|EMBL:KXX68392.1};
OS Flammeovirga sp. SJP92.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Flammeovirgaceae;
OC Flammeovirga.
OX NCBI_TaxID=1775430 {ECO:0000313|EMBL:KXX68392.1, ECO:0000313|Proteomes:UP000075267};
RN [1] {ECO:0000313|EMBL:KXX68392.1, ECO:0000313|Proteomes:UP000075267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SJP92 {ECO:0000313|EMBL:KXX68392.1,
RC ECO:0000313|Proteomes:UP000075267};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXX68392.1}.
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DR EMBL; LQAQ01000093; KXX68392.1; -; Genomic_DNA.
DR RefSeq; WP_062618650.1; NZ_LQAQ01000093.1.
DR AlphaFoldDB; A0A150AF75; -.
DR STRING; 1775430.AVL50_21735; -.
DR OrthoDB; 9815856at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000075267; Unassembled WGS sequence.
DR GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11641; Precorrin-4_C11-MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021745; CbiG_mid.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01465; cobM_cbiF; 1.
DR PANTHER; PTHR37477; COBALT-PRECORRIN-5A HYDROLASE; 1.
DR PANTHER; PTHR37477:SF1; COBALT-PRECORRIN-5A HYDROLASE; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11761; CbiG_mid; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000075267};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 50..129
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 134..224
FT /note="Cobalamin biosynthesis central region"
FT /evidence="ECO:0000259|Pfam:PF11761"
FT DOMAIN 227..349
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 360..565
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 614 AA; 68341 MW; 944AD858DB198042 CRC64;
MNKIAIIATT DRGLEQALIL QKEFPKSLVV TTRETDNEHV SVVASLSDYL SNYYHKLDGI
CFVSALGICV RLIAPYIETK ATDPAVVCMD DHGKNIQSVL SGHQGGANQF AEKIAQVVGG
KAIISTSSDL QEIWALDTLS QTYDWTVETD QPLNHLISLF VNNQPTALLL DVKDKGTAYL
EKNLPEFVTV FYDAEEIVAE QFELLIAVTY KIYDFNLPSL YYRPKVLALG SGCSKTLDFP
LFEARLKVEL EEQKIAFSAL KTFGSIDIKA QQSAYLDFSN KYYLPFVTFS KEAIDEVKVP
NPSEMVQSKI GVDGVSESTA MLLSKQNKVL VEKTKIHLEN DDKFTYSIAL IKDFERRSAV
AIIGAGPGDE ELITVKGKQY LEEADCVLYA GSLVPEEMIS WCKEGAIVRN SAMMTLEEQV
SLMFDQYKKG NAIVRLHCGD PSLYGAIQEQ MTIFDELGMD YFIVPGISSF SAAAAALKSE
FTIPEVVQSI VLTRGEGKTP MPAKESVEAF AKTNATMCLF LSAGIAKKVQ AQLLNHFDEN
TPVAVMYRLT WKDEEIYQGQ LKDLAQIVKD SKKTRTVLIV VGKAIGARKN RSQLYNPDWQ
HIFRTNKKFV VKEA
//
