ID   A0A150H831_9MICO        Unreviewed;       546 AA.
AC   A0A150H831;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=DNA polymerase IV {ECO:0000313|EMBL:KXZ58174.1};
DE            EC=2.7.7.7 {ECO:0000313|EMBL:KXZ58174.1};
GN   Name=dinB_2 {ECO:0000313|EMBL:KXZ58174.1};
GN   ORFNames=Bravens_01211 {ECO:0000313|EMBL:KXZ58174.1};
OS   Brevibacterium ravenspurgense.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC   Brevibacterium.
OX   NCBI_TaxID=479117 {ECO:0000313|EMBL:KXZ58174.1, ECO:0000313|Proteomes:UP000243589};
RN   [1] {ECO:0000313|EMBL:KXZ58174.1, ECO:0000313|Proteomes:UP000243589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCUG56047 {ECO:0000313|EMBL:KXZ58174.1,
RC   ECO:0000313|Proteomes:UP000243589};
RA   Bernier A.-M., Burdz T., Huynh C., Pachecho A.L., Wiebe D., Bonner C.,
RA   Bernard K.;
RT   "Use of Whole Genome Sequencing to ascertain that Brevibacterium
RT   massiliense (Roux, Raoult 2009) is a later heterotypic synonym of
RT   Brevibacterium ravenspurgense (Mages 2008).";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC       untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC       forks, which arise in vivo from mismatched or misaligned primer ends.
CC       These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC       exonuclease (proofreading) activity. May be involved in translesional
CC       synthesis, in conjunction with the beta clamp from PolIII.
CC       {ECO:0000256|ARBA:ARBA00025589}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXZ58174.1}.
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DR   EMBL; LQQC01000010; KXZ58174.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A150H831; -.
DR   PATRIC; fig|479117.4.peg.1207; -.
DR   Proteomes; UP000243589; Unassembled WGS sequence.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR   PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR   Pfam; PF00817; IMS; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:KXZ58174.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000243589};
KW   Transferase {ECO:0000313|EMBL:KXZ58174.1}.
FT   DOMAIN          51..174
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..436
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   546 AA;  58270 MW;  2F7CE3F003B73FBD CRC64;
     MSDAHRSGTA GSAVQKQPAE PGGTLRTLVL HVPDFTAVAH AEAAGVSPST PAVVLHAGRV
     ISADAQARAA GIAVGLNRRA VGHRCPQAAV LNYSEDTEQR LFARSVGILE DRMARFTLLR
     PGTIGVPVSS FARTHTEDTA AEELLTALTD ATGWEVLAGI ADSPFAAVLA AHRSHRVEPG
     QTAEFLAPLP VSTLAEAHPE RYADFTQQLG RLGLGTLGDL AALSADSVYT RFGSVGQTAR
     LLAAGLTESL PATHLRTADV TVSCPIEPPT GRTDALSFYA RSAAADLFRR VRSTGLVCTQ
     VTVVLHASGA EAEQRTWRLP DMDESHIADR VRWQADGWLA TRGGSAEPQA STAASPPDTG
     DGTDDGISLI ELTAAELVRP LENTADLFST RSGDVSRTLE RLQGLFGPDA VRVPHVQGGR
     EPSETNLWTP WQQTPRPLRD SRAPWPGALP APQPTLVDTA DIDLLDAHGS TVVARPSGLD
     SPPDRIVWPG GEHSRVIAYS SAWPVEAEWW DPPGQYRVRL QVLTDDDRAL LLKKENGQWS
     IAGRYE
//