ID A0A150KJI9_9BACI Unreviewed; 219 AA.
AC A0A150KJI9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000256|HAMAP-Rule:MF_01131};
GN Name=rex {ECO:0000256|HAMAP-Rule:MF_01131};
GN ORFNames=B4102_4300 {ECO:0000313|EMBL:KYC83096.1}, B5V89_15210
GN {ECO:0000313|EMBL:PTY77285.1};
OS Heyndrickxia sporothermodurans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Heyndrickxia.
OX NCBI_TaxID=46224 {ECO:0000313|EMBL:KYC83096.1, ECO:0000313|Proteomes:UP000075666};
RN [1] {ECO:0000313|EMBL:KYC83096.1, ECO:0000313|Proteomes:UP000075666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B4102 {ECO:0000313|EMBL:KYC83096.1,
RC ECO:0000313|Proteomes:UP000075666};
RA Berendsen E.M., Wells-Bennik M.H., Krawcyk A.O., De Jong A., Holsappel S.,
RA Eijlander R.T., Kuipers O.P.;
RT "Genome Sequences of Twelve Sporeforming Bacillus Species Isolated from
RT Foods.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PTY77285.1, ECO:0000313|Proteomes:UP000244181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAD {ECO:0000313|EMBL:PTY77285.1,
RC ECO:0000313|Proteomes:UP000244181};
RA Owusu-Darko R., Allam M., Ismail A., Buys E.;
RT "Whole genome sequence of Bacillus sporothermodurans.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYC83096.1}.
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DR EMBL; LQYN01000176; KYC83096.1; -; Genomic_DNA.
DR EMBL; NAZB01000039; PTY77285.1; -; Genomic_DNA.
DR RefSeq; WP_066236221.1; NZ_NAZB01000039.1.
DR AlphaFoldDB; A0A150KJI9; -.
DR STRING; 46224.B4102_4300; -.
DR GeneID; 62499771; -.
DR PATRIC; fig|46224.3.peg.2654; -.
DR OrthoDB; 9784760at2; -.
DR Proteomes; UP000075666; Unassembled WGS sequence.
DR Proteomes; UP000244181; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR PANTHER; PTHR35786:SF1; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01131};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01131};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|HAMAP-Rule:MF_01131};
KW Reference proteome {ECO:0000313|Proteomes:UP000075666};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_01131};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_01131};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_01131}.
FT DOMAIN 81..182
FT /note="CoA-binding"
FT /evidence="ECO:0000259|SMART:SM00881"
FT DNA_BIND 18..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01131"
FT BINDING 92..97
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01131"
SQ SEQUENCE 219 AA; 24709 MW; 6CD05594D4A1510F CRC64;
MNEELIKIPQ ATAKRLPLYY RFLRNLHNSG KQRVSSAELS EAVKVDSATI RRDFSYFGAL
GKKGYGYNVN YLLSFFRKTL DQDELTKVAL IGVGNLGTAF LNYNFMKNNN TKIEIAFDVD
PNKVGKKIGD VPIYSLDELE ARLISEDISV IILTIPAEVA QRVTDQLAKT NVKGILNFTP
ARLNVPSSIR VHHIDLAVEL QSLVYFLKHY PNDTEISQD
//
