ID A0A151BKU2_9ARCH Unreviewed; 632 AA.
AC A0A151BKU2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=AYL31_006410 {ECO:0000313|EMBL:KYH40526.1};
OS Candidatus Bathyarchaeota archaeon B26-1.
OC Archaea; Candidatus Bathyarchaeota.
OX NCBI_TaxID=1779370 {ECO:0000313|EMBL:KYH40526.1, ECO:0000313|Proteomes:UP000075365};
RN [1] {ECO:0000313|EMBL:KYH40526.1, ECO:0000313|Proteomes:UP000075365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B26-1 {ECO:0000313|EMBL:KYH40526.1};
RA He Y., Li M., Perumal V., Feng X., Fang J., Xie J., Sievert S., Wang F.;
RT "Evidence for homoacetogenesis among multiple lineages of the archaeal
RT phylum Bathyarchaeota widespread in marine sediments.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYH40526.1}.
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DR EMBL; LUCD01000049; KYH40526.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151BKU2; -.
DR STRING; 1779370.AYL31_006410; -.
DR Proteomes; UP000075365; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10322:SF20; DNA POLYMERASE 1; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 215..615
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 632 AA; 71949 MW; 2F161B571452F621 CRC64;
MAACYLIDIE AAPNGMRLIF YDPSEDTLTE VPDEEYKPYF YLPHPLPPEA RTLIESLHGR
TRVVEKRELF TGELKPLTKV EVEDPSDIQK LSRRLKNSWE DDVPPALGYA YDHDLSFGAP
YHIGEDSITP AYEIPSELKP LFEERFREVK ARDPEKYALI ERWFSLCYQP IPEASPAKLG
IAGEITRENL YLSFMLARVA SLPIPTASSS RKVSTWIRSM LHAFLRRENI LIPKPEELRR
GKEVHRVKGG LTIPPESGVH FNTVVVDFES LYPSLIDAYN LSYETVDCGH PECTGNKVPG
TEHHVCKKRR GIYAILIGAL KDLRIRWFKP LSKDPSLPES ERRLAEAAAR LLKLILVASY
GVTVRIRGLA QPALAESITA YGRHSLKEAW RIATEMGLHP LYGDTDSLFL DNPSEEAVNS
LIRRVKRDLL LDLAVDKRYS VCILPRAMKA YIGIRRDGTP DVKGLTALKS NSPRLVQKVF
MRCVKELTEV RNWAELEMAK ERIRRTVDKA IEDLKAGRLP LEDLEYSVRL HFNPYEKGVH
AEALHQPYQC AVQLLDSGLR VDIGEEVRFV KVKPFKYRGK TFTVKPTVLV RGFHEVNVDD
YVKSLISALN QTFKPMGMAF GKSLHRDLAD FM
//
