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Database: UniProt
Entry: A0A151GDI9_9HYPO
LinkDB: A0A151GDI9_9HYPO
Original site: A0A151GDI9_9HYPO 
ID   A0A151GDI9_9HYPO        Unreviewed;       345 AA.
AC   A0A151GDI9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=4-dimethylallyltryptophan N-methyltransferase {ECO:0000256|ARBA:ARBA00039094};
DE            EC=2.1.1.261 {ECO:0000256|ARBA:ARBA00039094};
GN   ORFNames=DCS_07096 {ECO:0000313|EMBL:KYK55134.1};
OS   Drechmeria coniospora.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Drechmeria.
OX   NCBI_TaxID=98403 {ECO:0000313|EMBL:KYK55134.1, ECO:0000313|Proteomes:UP000076580};
RN   [1] {ECO:0000313|EMBL:KYK55134.1, ECO:0000313|Proteomes:UP000076580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 6962 {ECO:0000313|EMBL:KYK55134.1,
RC   ECO:0000313|Proteomes:UP000076580};
RX   PubMed=26975455; DOI=10.1038/srep23122;
RA   Zhang L., Zhou Z., Guo Q., Fokkens L., Miskei M., Pocsi I., Zhang W.,
RA   Chen M., Wang L., Sun Y., Donzelli B.G., Gibson D.M., Nelson D.R.,
RA   Luo J.G., Rep M., Liu H., Yang S., Wang J., Krasnoff S.B., Xu Y.,
RA   Molnar I., Lin M.;
RT   "Insights into Adaptations to a Near-Obligate Nematode Endoparasitic
RT   Lifestyle from the Finished Genome of Drechmeria coniospora.";
RL   Sci. Rep. 6:23122-23122(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine
CC         = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:34435, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:58209, ChEBI:CHEBI:59789, ChEBI:CHEBI:67248;
CC         EC=2.1.1.261; Evidence={ECO:0000256|ARBA:ARBA00036016};
CC   -!- PATHWAY: Alkaloid biosynthesis; ergot alkaloid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005107}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYK55134.1}.
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DR   EMBL; LAYC01000003; KYK55134.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151GDI9; -.
DR   STRING; 98403.A0A151GDI9; -.
DR   InParanoid; A0A151GDI9; -.
DR   OrthoDB; 45787at2759; -.
DR   Proteomes; UP000076580; Chromosome 03.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR017804; MeTrfase_EgtD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR   NCBIfam; TIGR03439; methyl_EasF; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   PIRSF; PIRSF018005; UCP018005; 1.
PE   3: Inferred from homology;
KW   Alkaloid metabolism {ECO:0000256|ARBA:ARBA00022589};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076580};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          40..339
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
SQ   SEQUENCE   345 AA;  39096 MW;  55B638FE4F6C9A38 CRC64;
     MVPDQSPTHG EVVDIGGSSM ATQVSKSLRR ALTTQFGQDE RPVFPDELLY DDAGLRIWSE
     IIFTESFYQT HSEIKLLEEH GPELVALLQD EVTLIDLGAG DTRKVEHLLS VFESIQKPAT
     YLALDISKAS IQHNVAYLVE KHPAASSTVK CAGLWGTFQD GKKQVEKIKT PRLFLSLGSV
     LCNDPWPRAL EHLQYWVDAM VPGDLLLVGM DGHTLPDDEE KIWNSYHEGH DLYHKFFLNG
     LEHANRLLGE KCFKEHDWEF GAELGVDGKA TRHRFILRAK NEVKIGAHDR VIKQGEEFDW
     FDSHKYTEQD VTLMCSQAGL AVLKVWQAPQ SNFRQYLLTL KGKND
//
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