ID A0A151GVM9_9HYPO Unreviewed; 4479 AA.
AC A0A151GVM9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Amino acid adenylation {ECO:0000313|EMBL:KYK61154.1};
GN ORFNames=DCS_02295 {ECO:0000313|EMBL:KYK61154.1};
OS Drechmeria coniospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Drechmeria.
OX NCBI_TaxID=98403 {ECO:0000313|EMBL:KYK61154.1, ECO:0000313|Proteomes:UP000076580};
RN [1] {ECO:0000313|EMBL:KYK61154.1, ECO:0000313|Proteomes:UP000076580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 6962 {ECO:0000313|EMBL:KYK61154.1,
RC ECO:0000313|Proteomes:UP000076580};
RX PubMed=26975455; DOI=10.1038/srep23122;
RA Zhang L., Zhou Z., Guo Q., Fokkens L., Miskei M., Pocsi I., Zhang W.,
RA Chen M., Wang L., Sun Y., Donzelli B.G., Gibson D.M., Nelson D.R.,
RA Luo J.G., Rep M., Liu H., Yang S., Wang J., Krasnoff S.B., Xu Y.,
RA Molnar I., Lin M.;
RT "Insights into Adaptations to a Near-Obligate Nematode Endoparasitic
RT Lifestyle from the Finished Genome of Drechmeria coniospora.";
RL Sci. Rep. 6:23122-23122(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYK61154.1}.
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DR EMBL; LAYC01000001; KYK61154.1; -; Genomic_DNA.
DR STRING; 98403.A0A151GVM9; -.
DR InParanoid; A0A151GVM9; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000076580; Chromosome 01.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 6.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076580}.
FT DOMAIN 1253..1330
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1806..1879
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2885..2962
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3439..3512
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3993..4069
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4479 AA; 500103 MW; 7AA37ADD03ED5212 CRC64;
MPLDTVSCFI IQPAHTAEER AKFIILPRGE AGELALGGHQ LARGYLNRPD QTASAFIPTP
YGRVYRTGDR ARVTASGMLE CLGRLEAGQV KLRGQRIELG EIEQVVLKTP GCYGAVAVVI
NSTLVVFCAA DEGVTEDIAL EICTKWLPRY MVPSQLMIQR EFPRLPSGKV DIPKLKSDFN
VRNLSLNDTD TGHVVSVHDQ FVLQLVSETI GMQMNKETTL ASAGVDSLMA IKLASSLRAA
GFETSAPELL KMRMLSDLCS TLEGQSPTTP EGAETLDVSL LPELDQILAE NPDLQTMETP
VEDILPCTPL QSAMLAETAK NPETYSNEVE MQTCRGVSLD ALVAALMQVA NANMIYRTGF
VMHRGQHLSI IFKNFALEKI CLVDKFRRKF AISSPKDLLS PFGIQIQRPA VDSGPRLLLQ
IHHALYDGWS MDMLRADVSA LLRRIEVPSR PQHQKLVEYH ARNSDKDGFH DAARAFWSER
LLRWNRTPFP KLAARPAASR TSNKIWYKVD LTPDFVRETA KIHNVTAQVF FQAALVLVWS
RIMNEQDIVI GSVSSGRTIP VKGIERIMGP CMASLPLRVD ISTMCTSLDL LRNIQASNRA
AMEHCGLPLS EIKQIAGLQP AENLYDLLFV YQESPETAKG GHGLLEIAHW DRLETTLLLE
IEPQELEYDL QITHQSSVSA DFVDEFASQI QSVLRNLLTN PKDSIQYSMR SLKSRNSEYN
THPQMFRGTP DLAFTFEEIA MRMPERPALQ FFASLDDDLS KAIPMSYRDL NETANQIAHS
INTQSSIGEV VAIIMNKSNL LYTSILAIVK TGSAYLPILP TTPLARVRNI FGQAGIKRCV
VDSSSLKVFH FIEGVEFLNI DAIDTQHCSK DNMGVYADPS RLAYIIYTSG TTGDPKGIAI
TQMNILSNIS HLQKIYSVSA SWPRLLQACS HAFDVSVFEI FYAWFAGMCL CATTNDVLFE
DIEESIRRMG ITHLSLTPTV ACLIDPVNVP KVEFLVTAGE PMTLAVSKQW GDRLWQGYGP
SETTNICSVK RMMKGENIEH LGWVLPNTSV VVLAPDTLDA IPIGWVGEFC FGGDQVAQGY
HKNFSLSSKS FLLHPQFGRI YRSGDIGRML PDGSLSILGR LDDQIKLRGQ RIELNEINGI
ITSNSVTRAA ITMLVRRETG TPDQLASLYV SPNSSTLFEF MQVDQETNRL LFSNIQSRVP
SYMVPSYLLP VSYIPHTPSG KIDTAVIQEG FKKLPSHYLE TGSFTTQVVD NDSEWSDIEI
SIADVISRTK GICRSDLGRW TPFAAVGIDS ISAIDTAKEL SSQLQVQISI STILLNPSIA
QLGKAVEDNK PGLVSTWQEQ LAPAYDLATE LSDQVRNSFS YDRNNIEDIL PCTPLQEAML
SRGQGSYCTK ILLRVRIPAA DMARYWDEML RRHVILRTCF VTTKNVTHPI VQVVLQRFEI
TIQTHEVQAP SLAGAIHEHL ATIPEPLDSG HPPLSLAFFR YNDSEFLSFI CHHALYDGVA
MECLWREVEA LANGRTLLPP VPYKPFLQQS LIFPDDTDSF WTEQFRSFRH SILFPRSASG
EINQSTHRTS LSMSLHEVQA RLTLLGTSLL AACQASWATV LSVLCNHADI AFGNVVSGRT
LDMGGLDRLV APCFNTIPIR MDISRSSQNI DLLRSFHHLN EKMLRYQFSS LRRIQFLANC
HGRSLFDTLL LLQQPLKDMD ERVWTLEEDS GNMDMALVCE IVPCPNLNSV VVNIHHDLGV
VTGDHAANLA DLFKHSFLHL FASPYSSPID QNSAPTRITS GLEGLIRNGR NFELSDQKES
EHDKWTGVEE KIRGALSELS QVPEARIFPN TSIFHLGLDS INAVQISSML RRQGFNISAT
DVIECPSPAK LAKRIALSCG RAGNLPALEF SFEQFYTDVS VEINGLMNQG GVEAVLPCTS
VQCAMLASFM QSGGQNYCSM LCYKVQSGIN TLALLHAWKL VQRNHQMLRT GFVPVRHQAC
TFAMVRNSIG QTEEAVECFH AIKSSTFEPT SWKEKMRRII MQKLHLPPWR VALVESGNGV
NMYVLMHHAL YDANSLDGIL GGVADAIHGQ VRRFAEVEPA LAEMLSQSLN QQQINTRNFW
EAKSENTVVN TFPVMTPLRE QKSVLQTHET DSAISLKLLE ESAKYLGSSV QAIIQAAWAR
VLSSYLGESS VVFGVTLSGR TSEATRVAPF PCITTVPVIA QNVESNREII RAMMDYNSEL
RKHQFAPLSV IQKWLGHPGH PVFDTLVVYQ KRGAGGTEQQ PWSLSYVDFQ AEYAVSLEVE
PANENTIRLF LNYAPDVLPE AQARLLTRQF DILLEYLCRE PDGKEQDLYR ANILEFSITP
PRILALPSPV RFLHEFVEQG SLAHPTRIAL EFASAFKAGR AIKQTWTYRE IDRIGNQAAH
LVNYRAAPGS IVAIHFEKCP EAYFAILGIL KAGCSFVALD PNAPKARKDF ILRDSNAVCL
MTNTYSTIDF NIPIAGALLK FDTISLEQYP DRCLDLGAEF STNNTCYCLY TSGTTGEPKG
CEITHENAVQ AMMAFQELFK GHWDDEARWL QFAALHFDVS VLEQYWSWSV GITVVAAPKD
LILDDLSGSI SMLEITHIDL TPSLARLTHP DDTPTLCKGV FITGGESLNQ EILDTWGSKA
VIYNAYGPTE ATIGVTMYPR VPINGRPSNI GKQFPNVGSY VFRPGTDIPV LRGGVGELCI
SGKLVGKGYL NRPELTEQRF PTVVEFGERI YRTGDLVRIL HDGCFDFLGR NDDQVKLRGQ
RLEIGEINHV IRHGAQEVQD AATIVVRPIS SGRDILVSFL VGQLDRSQKL CTLFDTDGLG
AKARLACLKQ LPAYMVPSYF LRLPYIPLSS NEKVNFKELK DLFESLSHDQ LSKLVSAATP
LDMSQFDQQT FQKVINILTD FGSLKHDSIS SSSSIFDIGV DSVAVLQLSA MFKSQGFDAA
SPVVLLRHHI VADLVRVLSE KSNSEGQLDL VLEAQQYIKA CSHRYRPLVC RELGVTSSEI
EYIAPCSPLQ HGIISKAMTC ERRGMYFNSF LLKLKGDDIS IEMVYQAWTR LVESHAILRS
AFVNTSDGYI QVALKHPPSV WSDHWVSSEG EADEILKSRR HGWIADNSHH IRTPLQLIQV
QGPGFRRIVV HMFHSLYDGN SLELMNQYAM LVYRNNEEKL GPRFVEALAY GPLWNYDHCR
DFWTQYLKGW VFSPVLTSLD VPFELRTVSA TRFISLERFE DMRRQQTVTL QSVVLAVWAS
ILRKHLGSSL TIGILVSGRS INLPDVENTI GPMFNTIPYF IKTLAGHTWG SLIRAVHKFS
TSILPFQHVP LQSIQKWCSI GRPLFDNLFT FQVELPQASD DLPWTILDSH GQLDYPLSLE
VIKTRTGLLK LNLVSQNNFT DSKMLEELLN KLEMAIDTAH PNDMVDPSAV DYVDLVSTTL
CSNVSGDNFT AINIPLDWSG SMSLVRDEIA FLAEIPVQNI TENTTLLELG LDSIDIMKLS
MNLKKRGIDI PASKIMRFQK IPRFMQEQNL NAPDTASTLN DTFLQQIKQK LHSYVDSTGL
DMRTVEAVLP PTPLQEAMVA DMLQSNFGRY FNHDILEVAE GVDIQKLYNA WAQVVEKSPI
LRTGFVEVGD PGLDMTYCQV VFRNHTHMAS VKLSNQSEIQ TITESAIKLA IYGKGMKNLF
QVTFATIQSR HFVVLSVAHA LYDGWSLELM YQDLQAAYDG ESCARVSAEI FISQMLASRT
DEAQCFWASY LDGLSPTLLQ GQKSPPVHDA DQVFRKEMDS NETLSSMMNH CKNISVSLQV
LCLACWAVAV AEWTHSLDVV FGVVLSGRDF EGAGELMFPT INTITMRCIL HGSVREFLRY
LEDSMADIRN FQAFPLRKAQ AVTKVAMSDI FNSLFLVQKS VKVEHPSSKL LKSVNGTSAV
NYPVCIEAEP VADRLRWRIA CQSHFFSDED TLQLIRNVNG ILSYILQAGS EDILSFHEDN
LSICGMPPIA IKDTAAQKPN ATEEDFLQDG QEQELSETAK VIIEVLGQVS VTPVQDIKPS
FSLYHLGLDS ISAIKVSMLL RSRGIDIKPR ELVNTSSISE LARIAGLTAD SADAGPIKAV
PWKPPQETNL DTLMSACGLP MDDVEEILPA MPMQAFMLTH WQNTHGSVFF PEFRYRIDGV
LDDKVIYNAW NKLLVLMPIL RTRFISTGNQ ELPWLQCIFN ADSFSSGRVS QPLIKLHVLY
DKNPVLRVRI HHALYDGVSL PAMMSCFVGL LNDQCVVNIN LPAWIDSCIR PTISVEQDKR
RKFWIDYLKR TPSDSSESCI SNSTETTSCL VESAIGDITR VRTIAARHGT SLQSLFLAAY
AKSKARDRPS SAVFGLYLAN RTRLEFPLPP TLPTLNLVPI KIQLREQESL LTIAREIQRH
INAISSHGRA DVGLWEIFQW TGVKVDSFVN FLSLPDEPSA AGQKITMTMM KEAGLRPASF
DSATLLEERW LQNNAIRNAY PVCSRRWFFP FLLGHRSIK
//
