ID A0A151I2X4_9HYME Unreviewed; 1503 AA.
AC A0A151I2X4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Regulator of G-protein signaling 12 {ECO:0000313|EMBL:KYM80882.1};
DE Flags: Fragment;
GN ORFNames=ALC53_08695 {ECO:0000313|EMBL:KYM80882.1};
OS Atta colombica.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=520822 {ECO:0000313|EMBL:KYM80882.1, ECO:0000313|Proteomes:UP000078540};
RN [1] {ECO:0000313|EMBL:KYM80882.1, ECO:0000313|Proteomes:UP000078540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Treedump-2 {ECO:0000313|EMBL:KYM80882.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM80882.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Atta colombica WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KQ976551; KYM80882.1; -; Genomic_DNA.
DR STRING; 520822.A0A151I2X4; -.
DR Proteomes; UP000078540; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048699; P:generation of neurons; IEA:UniProt.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR PANTHER; PTHR45945:SF3; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000078540};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 19..96
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 803..920
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 1052..1122
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 371..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1437..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KYM80882.1"
SQ SEQUENCE 1503 AA; 167446 MW; E49B88863AF27D87 CRC64;
ADMHQNRRKK KRVNYGVRAV EVVRGTKGFG FTISGQQPCI LSCIVQGSPA EGAGLRAGDY
LVAVNGHNVS KVPHDDVVQL IGSSKGILRL QIAENYYSDS SDEEGLATVR SKPKYAHKPR
TASTSALQLQ CRAAKVVRDL QSGAMFHTDG LAMPDAKDQY NYSGLHYRWN MTSPLPLPPP
PASHKRDSEK IVHRTVVGYL GTIDIPNQLH PSSMMQVLRK CIKRLKAEKR NPTTVLLTIH
VANIKLTNSE NRIIAEYPSY RIIFCNSFSE QDKQYFGILT KSMRNTDDIV SNSCHVFTIY
YKLIDHEVHS SACNVFGFMC TKSSELNVCQ EFPDSCTSLI GAIQTLYISD CTNGENCTNP
YNEARMRLDT ASPQPSNIST STAHSSNSDS GIGFKDDYGS CSSKNLTNDN VSARLSKEPV
NEAAGHRLTV RATSEARLWS EELKFDLSKV AMVGNYEMKL FTEMRHVAGS GKGTTTTCAE
TSAPAATART MLASTSVGSL ASVCTTALLD GIEDVESSKV TSTEELKRLM DTTNKLSPKV
YCGQITKSLV HSLEDINSSM EYARQPYCHS YSGKSDKPRP WGSLQEIRNF RNSASDNCIS
RWERKRSGAS DGSTMRMNQS RNNIGGEGEC GSNRVAHDVC SRDDVADDYV VLATRYRYRQ
QLVVSCDTSR YVTSGHVCQG PRHAVLSLPT STSSALLPIP RQSMQSLVRA STERLINDIA
VVVTDVKTKK SHGQVCSEYS AVHREHCCMR HVSLSPRQFV DDAWFGKFGM DPFLGKVSSS
VYGSTESCDK NNDCKGVHTW ANGFEKLLED PKGLQTFAEF LKKEFSHENI YFWAACERYK
DTKDTTMRRR LACQIYQRHL SNTAAEPVNV DSHASGQITQ ELLDEAPADL FLQTQKQVFN
LMKFDSYPRF LRSELYRACL EAGSAVVDTE DCDLHLTSSP SVKLKKSHSD AEDRCRKSLL
PWNRKNRSKS KDRGESEYNK TPSRSETIYK SFTVIKRETE GNNNEDTVSI SSSRSSLASW
DLALRQSFNK HSVSSYDGQM NEKKDARSKC TGLCRVILPD GSTTVVTTSQ TESIKDVVTR
LLDKRALRYS NYDVLILATD EMVDTKCFSS VLAGQEVEVV PTKVLKVELP SRRIISIIAH
KGKTLKEILR PLLNKYGFNL DLISIWSEGR CVPMDIMAIN APTRIIVMAN EEDFQRELHT
AKYLDEVPHA QPTLDEITNK VFEELLVGKR NKYQYSEGSC KSDDQRSEGS SILSSKFFLR
DSTIHGKKKA KSKCCNTSEK SNTNDCIHEG APIKSQPPLI AKWRNGVKLQ LPGRFDGDEL
YEGLKRAQRS RLEDQRGTEI NFELPDFLKN KENGKPSDSN KMRRTRVVSA NCEGTTKFYD
SSEDKQSSSG YEYSAHVTNG AVNERFSALV NITEPLSKCL ESSFNLDGDR TLMDGDQTII
ENGTDSPSKS PYSGSYGGTD VSHTKLSKPP PLPPKPKNLV VNVVKSGYVT SPKTLQRPNH
VIE
//
