ID A0A151IEZ9_9HYME Unreviewed; 717 AA.
AC A0A151IEZ9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Engulfment and cell motility protein 1 {ECO:0000313|EMBL:KYM99513.1};
GN ORFNames=ALC62_09743 {ECO:0000313|EMBL:KYM99513.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYM99513.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYM99513.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYM99513.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM99513.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; KQ977811; KYM99513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151IEZ9; -.
DR STRING; 456900.A0A151IEZ9; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771:SF56; CED-12; 1.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 311..481
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 717 AA; 81703 MW; DB2F3B6074DCD64C CRC64;
MPVQKDSNIV KIAVQMTDQM PQLIEFNQKQ PLAGIIQELC NGWSLSDAES YSLQFSESNN
QNYITEKNRN EVKNGSILRL EFSPSKTASD ILAKLNSIAE EKVAALQKLS ILSIDMTFAL
EFINKKGLAL IISQVEGGKY KGNTLAYSLQ SFVELMDHGI VSWDILEIPF INKVASYVNN
QSVTQDTSIV EASLSILENI VLNSTGKYGQ VEKEVTFPNL VMHLQCMNPQ IQQNAIALIN
ALFLKADLHK RRAVSATLQS KQVRNVFLTN VIQSTGQVGA EMAHQLYVLQ TLMLSLLEQR
MMTKMDPQDQ DAHDKIKELR RIAFDTEGAN SGDVAARKGL FAKDYKKLGF KYDINPALDF
TETPPGMLAL DCMVYFARNH TEAYTKVVLE NSCRADEHEC PFGRTSVELV KLLCEILRIG
EAPSEQGQSY HPMFFTHDHP FEEFYCVCIV LLNKTWKEMR ATTEDFVKVF SVVREQITRA
LQCKPTGLDK FKNKLQQLPY STITNLWQQE RTNREEWESH ARPIVELREQ ITPEILELIQ
QQRLGFLVQG TRFMKYSARG QRIKDKFWYV RLSPNHKVFH YGDCDEKSVP MIDELPTKLA
VVEIRGLLTG RDCPHMKDLQ RRKTTHQLAF SLVLDSVEVS SLDFVAPDEQ VFDYWTDGIS
ALLGNRMTSK EAENDLETLL SMDIKLRLLD AEGIDIPQDP PAIPEPPPNY DFCYELK
//
