ID A0A151IK00_9HYME Unreviewed; 1278 AA.
AC A0A151IK00;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Muscarinic acetylcholine receptor DM1 {ECO:0000313|EMBL:KYN03953.1};
GN ORFNames=ALC62_05254 {ECO:0000313|EMBL:KYN03953.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYN03953.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYN03953.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYN03953.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN03953.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the AHA1 family.
CC {ECO:0000256|ARBA:ARBA00006817}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KQ977294; KYN03953.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151IK00; -.
DR SMR; A0A151IK00; -.
DR STRING; 456900.A0A151IK00; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IEA:InterPro.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:InterPro.
DR CDD; cd15301; 7tmA_mAChR_DM1-like; 1.
DR CDD; cd08892; SRPBCC_Aha1; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.15.10.20; Activator of Hsp90 ATPase Aha1, N-terminal domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR036338; Aha1.
DR InterPro; IPR015310; AHSA1-like_N.
DR InterPro; IPR013538; ASHA1-like_C.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000995; Musac_Ach_rcpt.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF268; MUSCARINIC ACETYLCHOLINE RECEPTOR DM1; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR Pfam; PF09229; Aha1_N; 1.
DR Pfam; PF08327; AHSA1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR SMART; SM01000; Aha1_N; 1.
DR SUPFAM; SSF103111; Activator of Hsp90 ATPase, Aha1; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 671..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 832..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1189..1210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1230..1253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 687..1246
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 551..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..620
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1184
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1278 AA; 144498 MW; A58AFED90572ED05 CRC64;
MAKWGEGDPR WIVEERPDAT NVNNWHWTEK NACVWSQEKL KELLINFKIE GEGVSCKVTE
MEKCEGEAVA NNRKGKLIFF YEWNIVLKWI SDETSNKDIE GKINIPNLSE ENDISEVDIE
ITLKDSTDEG EKVKQFLHTK GKDAIREKLK KYVSSLKEEF TKGMILPKKD TDKEKENISN
ITSGFNIKMQ MNAAVTPTNN NKSASKISTT TIKQNVKFQC RADEFYNVLS SIEMVQAFTK
NPVKLEPKKN GQFELFGGNI HGEFIEITPT KIIQKWRCKQ WPSGHFSDVT IDISEKNDHT
EVNLTQSGVP VSKIVMRKCR DFQRGALYEG ELGQNNRTDC VQSHAVARAL DFCGSIDELS
SFSISFGARS AGTRASVSRP ERVEAALNHT CNRSRVRQSV SDSLTGPHVA VDRTSVVVVV
VGVMTTVSDR CSYSHVPRCR HVSARAPSLT PALRRLPFHP LSPSTHSTRA SIARGCRRDI
PDLAIQIPSI YSPPHRQASS MPCALNREVI ALHTWRNMHP STPLPQQQFD RLARDIELAA
FDEESVAIMT VIDESTTTEA VDEEEEGGEE EEEDEESEED EDNNDDDDDG HDDDDHDDDH
DDDDDDDDED DDDEEENEKE EVEKGRDRYG SVSEDMNVTS MVEIFGNDSN NVSNGLDCGG
EPHQYALWER VTIVVIAVVL SFTTVGGNIM VMISFKIDKQ LQTISNYFLF SLAVADFAIG
LISMPLFTLY TVLGYWPLGP YVCDTWLALD YLASNASVLN LLIISFDRYF SVTRPLTYRA
KRTTVKAAIM IGSAWGISLL LWPPWIYAWP YIEGQRTVPM TSCYIQFIET NHYITFGTAI
AAFYVPVMIM TFLYWRIWKE TKKRQKDLPN LQAGKQDASK RSNSSDEVII DMEEGRRQRS
ESSTADDVSH ATHIAVSYID KHYPQYKSHR PFSWTWLKMW CIAWWHSGRD DEDDDEEIAG
PESSHTGAGY EDTLTPLSAE TPLPSTVSRC PSISAIQATG IALDKTMLHE YKRSARPVDL
RNISNDTVCD ASILSRNLYL NVYLKFDENK KKNCSEKFSV IIRNKTVIFE IAIESIDSRS
KIHTTRVSLL QFQIYTILIK LPSNGGKFTE GTSIRMIPDD GSGASRLFRL GGGSVSSPST
VTMRRPSQMP DIRIPLNAKN IPKAGKGILS KQPNKKKKKL QEKKADRKAA RTLSAILLAF
IITWTPYNIL VLLKSITACS WYIPQVLWDF VYYLCYINST VNPMCYALGN AAFRRTYVRI
LKCKWHSRNR GTGAVDRG
//
