ID A0A151ILZ0_9HYME Unreviewed; 1449 AA.
AC A0A151ILZ0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Regulator of G-protein signaling 12 {ECO:0000313|EMBL:KYN05900.1};
GN ORFNames=ALC62_03169 {ECO:0000313|EMBL:KYN05900.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYN05900.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYN05900.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYN05900.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN05900.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KQ977085; KYN05900.1; -; Genomic_DNA.
DR STRING; 456900.A0A151ILZ0; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048699; P:generation of neurons; IEA:UniProt.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR PANTHER; PTHR45945:SF3; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 17..94
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 197..297
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 748..865
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 997..1067
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 371..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1449 AA; 161473 MW; 5E67EA0A78B0EDCE CRC64;
MHQNRRKKKR VNYGVRAVEV VRGAKGFGFT ISGQQPCILS CIVQGSPAEG AGLRAGDYLV
AVNGHNVSKV PHDDVVQLIG SSKGILRLQI AENYYSDSSD EEGLATVRSK PKYAHKPRTA
NASALQLQCR AAKVVRDLQS GAMFHTIPGG LATSDAKDLY NYSGLHYRWN MTSPLPLPPP
PASHKRDSEK IVHRTVVGYL GTIDIPNQLH PSSMMQVLRK CIKRLKAEKR NPTTVLLTIH
VANIKLTNSE NRVIAEYPSY RIIFCNSFSE QDKQYFGILT KSMRNTDDIV SNSCHVFTIY
YKLIDHEVHS SACNVFGFMC TKSSELNVCQ EFPDSCTSLI GAIQTLYISD CTNGENCTNP
YNEARIRLDT ASPQPSNIST STAHSSNSDS GIGFKDDYGS CSSKNLANDC ERRRQYSNMQ
YRNISARLSK EPVSEAAGHR LTVRATSEAR LWSEELKFDP SKELFTEMRH VAGSGEGTTT
TCAGTSAPAA TARTMLASTS VGSLASVCTT ALLDGIEDAA ESSKVASSEG LKRLMDTTNK
LSPKVYCGQV TKSLVHSLED INSSMEYARQ PYCHSYSGKS DKPRPWGSLQ EIRNFRSSAS
DNCIRWKRKR SGASDGSSRR RRRRPLFHLI RAKVCDRRPV RASTVRLIND VAAVAADVKN
VRPASVTWMR WRNRHGQVCS GSGCSGVHRE RCCMRYVLLS PRQFLDDAWF GKFGMDPFLG
KVSSSVYGST ESCDKNNDCK GVHTWANGFE KLLEDPKGLQ TFAEFLKKEF SHENIYFWAA
CERYKDTKDT VMRRRLACQI YQRHLSSTAA EPVNVDSHAS GQITQELLDE APADLFLQTQ
KQVFNLMKFD SYPRFLRSEL YRACLEAGSA VVDTEDCDLH LTSSPSVKLK KSHSDAEDRC
RKSLLPWNRK NRSKSKDRGE SEYNKTPSRS ETIYKSFTVI KRETEGNNNE DTVSISSSRS
SLASWDLALR QSFNKHSVSS YDGQTNEKKD ARSKCTGLCR VILPDGSTTV VTTSQTESIK
DVVTRLLDKR ALRYSNYDVL ILATDEMVDT KCFSSVLAGQ EVEVVPTKVL KVELPSRRII
SIIAHKGKTL KEVLRPLLNK YGFNLDLISI WSEGRCVPMD IMAISAPTRI IVMANEEDFQ
RELHTAKYLD EVPHAQPTLD EITNKVFEEL LVGKSRNKYQ YSEGSCKSDD QRSEGSSILS
SKFFLRDSTI HGKKKAKSKC CNTSEKGNSN DCIHEGAPIK SQPPLIAKWR NGVKLQLPGR
FDGDDLYEGL KRAQRSRLED QRGTEINFEL PDFLKNKENG KPSDSNKMRR TRVVSANCES
TAKFYDSSDD KQSSSGYEYP AHVTNGAANE RFSTLVNITE PLSKCLESSF NLDGDRTLVD
GDQTIIENGT DSPSKSPHSG SYGSTDVSPT KLSKPPPLPP KPKNLVVNVV KSGYIASPKT
LQRPNHVIE
//
