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Database: UniProt
Entry: A0A151IMZ6_9HYME
LinkDB: A0A151IMZ6_9HYME
Original site: A0A151IMZ6_9HYME 
ID   A0A151IMZ6_9HYME        Unreviewed;       584 AA.
AC   A0A151IMZ6;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   08-MAY-2019, entry version 18.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   ORFNames=ALC62_02747 {ECO:0000313|EMBL:KYN06312.1};
OS   Cyphomyrmex costatus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
OC   Formicoidea; Formicidae; Myrmicinae; Cyphomyrmex.
OX   NCBI_TaxID=456900 {ECO:0000313|EMBL:KYN06312.1, ECO:0000313|Proteomes:UP000078542};
RN   [1] {ECO:0000313|EMBL:KYN06312.1, ECO:0000313|Proteomes:UP000078542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MS0001 {ECO:0000313|EMBL:KYN06312.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KYN06312.1};
RA   Nygaard S., Hu H., Boomsma J., Zhang G.;
RT   "Cyphomyrmex costatus WGS genome.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   EMBL; KQ977018; KYN06312.1; -; Genomic_DNA.
DR   RefSeq; XP_018407102.1; XM_018551600.1.
DR   GeneID; 108783113; -.
DR   OrthoDB; 776697at2759; -.
DR   Proteomes; UP000078542; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR000333; TGFB_receptor.
DR   InterPro; IPR017194; Transform_growth_fac-b_typ-2.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PIRSF; PIRSF037393; TGFRII; 2.
DR   SMART; SM00467; GS; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR037393-2,
KW   ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078542};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR037393-3};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR037393-2,
KW   ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179, ECO:0000313|EMBL:KYN06312.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    584       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007582239.
FT   TRANSMEM    168    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      244    274       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      275    583       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   BINDING     306    306       ATP. {ECO:0000256|PIRSR:PIRSR037393-2}.
FT   DISULFID     61     81       {ECO:0000256|PIRSR:PIRSR037393-3}.
SQ   SEQUENCE   584 AA;  65504 MW;  DB8B2702EB2CB373 CRC64;
     MADAIFITHV ILLLTLRLCS GEQEIALQEQ DISFDDEKSD SPEPLDPNFG FNTNGQKRFK
     CHICEDFECV QSNVCNNAIT CWKSRVREVN GKEYVSRGCY KSEEHKLMMC NKENSQNNIE
     HKKRNVRGLS GGVQYSVECC QADFCNVGPY PKLEDSTNTN KEYHVIRLTF VILGLLSGML
     IFGGIALCLF IHRVRRKRPT VPRRNKLILD SEIEPSMLHF SFSSPTSSAT YHSHELRATA
     AGDSILKEYL DGRSLTSGSG SGLPLLVQRT LAKQVALVEC LGSGSSGGFG GEVWRGVWHG
     ENVAVKIYFS RDEAAWARET EVYSQLLPSR HDNILGYIGS DMTSRASCTQ LWLVVQYHPL
     GSLFDHLNRS PHPLTPHQTL NICLSIANGL LYLHTEIHGT KGKPAMAHRN LKSKNILVKT
     NGGCVIADFA LAATQDRLIA DRVDLRQGTK RYMSPEILEQ TVNVECLESF KRADIYSLGL
     ILWEVCRRCI SNGVALEYAM PYSEWLPNSN QEPSIEEMRK LVSFDQRRPS LPNRSHSDPT
     LAGMGKLMRE CWHGKPAARL PILRVKKTLV KLAASDSRVH LPLD
//
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