ID A0A151JJA7_9VIBR Unreviewed; 706 AA.
AC A0A151JJA7; A0A151L1B0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=guanosine-3',5'-bis(diphosphate) 3'-diphosphatase {ECO:0000256|ARBA:ARBA00024387};
DE EC=3.1.7.2 {ECO:0000256|ARBA:ARBA00024387};
GN ORFNames=ATY37_02755 {ECO:0000313|EMBL:KYN90129.1}, AUQ44_09360
GN {ECO:0000313|EMBL:KYN25643.1};
OS Vibrio cidicii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1763883 {ECO:0000313|EMBL:KYN25643.1, ECO:0000313|Proteomes:UP000075349};
RN [1] {ECO:0000313|EMBL:KYN25643.1, ECO:0000313|Proteomes:UP000075346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2538-88 {ECO:0000313|Proteomes:UP000075346}, and 2756-81
RC {ECO:0000313|EMBL:KYN25643.1};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KYN90129.1, ECO:0000313|Proteomes:UP000075349}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2538-88 {ECO:0000313|EMBL:KYN90129.1}, and 2756-81
RC {ECO:0000313|Proteomes:UP000075349};
RA Tarr C.L., Gladney L.M.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP +
CC H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2;
CC Evidence={ECO:0000256|ARBA:ARBA00024273};
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GDP: step
CC 1/1. {ECO:0000256|ARBA:ARBA00024329}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYN25643.1}.
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DR EMBL; LOMK01000001; KYN25643.1; -; Genomic_DNA.
DR EMBL; LOBR01000007; KYN90129.1; -; Genomic_DNA.
DR RefSeq; WP_061893589.1; NZ_LOBR01000007.1.
DR UniPathway; UPA00908; UER00886.
DR Proteomes; UP000075346; Unassembled WGS sequence.
DR Proteomes; UP000075349; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KYN25643.1}.
FT DOMAIN 45..144
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 387..448
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 632..706
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 706 AA; 79618 MW; 2071C113AFA7F317 CRC64;
MYLFDSLKDV AQEYLTEPQI EALRQSYVVA RDAHEGQTRS SGEPYIIHPV AVARILAEMR
LDLETLQAAL LHDVIEDCDV SKEDLEAKFG QAVAELVDGV SKLDKLKFRD RKEAQAENFR
KMVLAMVQDI RVILIKLADR THNMRTLGAL RPDKKRRIAR ETLEIYAPLA HRLGIHNIKT
ELEELGFEAL YPNRYRVLKE VVKSARGNRK EMIQRIHSEI EGRLQDVGLN ARVLGREKNL
FSIYNKMKTK EQRFHTIMDI YAFRVVVDTA DTCYRVLGQV HSLYKPRPGR MKDYIAVPKA
NGYQSLHTSM VGPHGVPVEV QIRTEDMDQM ADKGVAAHWS YKGNGDRTGT TAQVKAQRWM
QSLLELQQSA GNSFEFIENV KSDLFPDEIY VFTPKGRIVE LPVGATAVDF AYAVHTDVGN
TCVGARVDRN PYPLSKALKN GQTIEIISAP GARPNAAWLN YVVTSRARTK IRQVLKTMRR
EESITLGRRL LNHALGEHSL SDISPENMEH VLSDLKIASL DDLLAAIGLG ERMSIVIARR
LLGDAEELTE VATPEGKPKK KLPIRGSEGL LLTFANCCHP IPDDSIIAHV SPGRGLVVHR
ETCPNVRGYQ REPDKYMAVA WSEDYDQEFI AELKVDMQNH QGALAELTNV ISKTGSNIHG
LSTEERDGRL YTVTVLLTTK DRVHLAGIMK KIRVMPSCSR VRRRKN
//
