ID A0A151JN25_9HYME Unreviewed; 382 AA.
AC A0A151JN25;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 08-NOV-2023, entry version 22.
DE RecName: Full=Protein phosphatase methylesterase 1 {ECO:0000256|PIRNR:PIRNR022950};
DE Short=PME-1 {ECO:0000256|PIRNR:PIRNR022950};
DE EC=3.1.1.- {ECO:0000256|PIRNR:PIRNR022950};
GN ORFNames=ALC57_02958 {ECO:0000313|EMBL:KYN27658.1};
OS Trachymyrmex cornetzi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=471704 {ECO:0000313|EMBL:KYN27658.1, ECO:0000313|Proteomes:UP000078492};
RN [1] {ECO:0000313|EMBL:KYN27658.1, ECO:0000313|Proteomes:UP000078492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tcor2-1 {ECO:0000313|EMBL:KYN27658.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN27658.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex cornetzi WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Demethylates proteins that have been reversibly
CC carboxymethylated. {ECO:0000256|PIRNR:PIRNR022950}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester +
CC H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) +
CC methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-
CC COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790,
CC ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000906};
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00008645, ECO:0000256|PIRNR:PIRNR022950}.
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DR EMBL; KQ978889; KYN27658.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151JN25; -.
DR STRING; 471704.A0A151JN25; -.
DR Proteomes; UP000078492; Unassembled WGS sequence.
DR GO; GO:0051723; F:protein methylesterase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR016812; PPase_methylesterase_euk.
DR PANTHER; PTHR14189:SF0; PROTEIN PHOSPHATASE METHYLESTERASE 1; 1.
DR PANTHER; PTHR14189; PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR PIRSF; PIRSF022950; PPase_methylesterase_euk; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR022950};
KW Reference proteome {ECO:0000313|Proteomes:UP000078492};
KW Serine esterase {ECO:0000256|PIRNR:PIRNR022950}.
FT DOMAIN 73..363
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF12697"
FT ACT_SITE 148
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
FT ACT_SITE 350
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
SQ SEQUENCE 382 AA; 41894 MW; 29408B91DEFB2E30 CRC64;
MSALQKSVLK SRLPPSAINF SALNSRLSKS RGAQRRRDYE PVRWDPYFDH SKDVPVGQNT
FHVYIKGTEG PLLILLHGGG YSGLTWAELT KSIMTMVLCR VMAIDLRGHG DTHTTDDDDL
SADTLASDVA AVIDVIAHDD PIILVGHSMG GAVAVRAAPL ISNLYGLGVI DVVEGTAMDA
LASMQSFLRS RPSSFSTISQ AIEWCVRSGQ IRNIQSAKVS VPGQIKNIET SKLATHDIDS
LPTQYNKCES NPEPVIPRDD IIQEEESSNM PPPPPASSAI TTNRKYVWRI DLAKTEQHWF
GWFKGLSTAF LNVPAPKMLL LAGVDRLDRE LTVGQMQGKF QMQVLPACGH AVHEDVPDKV
AEAIATFMVR HKFAEPASDF PR
//
