ID A0A151LYW5_ALLMI Unreviewed; 533 AA.
AC A0A151LYW5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Cytochrome P450 2D6 isoform B {ECO:0000313|EMBL:KYO17441.1};
GN Name=CYP2D6-1 {ECO:0000313|EMBL:KYO17441.1};
GN ORFNames=Y1Q_0020055 {ECO:0000313|EMBL:KYO17441.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17441.1};
RN [1] {ECO:0000313|EMBL:KYO17441.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17441.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO17441.1}.
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DR EMBL; AKHW03007000; KYO17441.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151LYW5; -.
DR STRING; 8496.A0A151LYW5; -.
DR eggNOG; KOG0156; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF1; CYTOCHROME P450 2D6-RELATED; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01686; EP450ICYP2D.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 61863 MW; 2A2920957F25E61D CRC64;
MYVEEETSKG GSSKEYKRSR SWSRYPPGPT SLPFLGTILQ VNFYNPHLSF NQLSKKFGNV
FSLQYFWTNV VVLNGYEAVK DALVQKAEDF ADRPYFPRYE HLGYNKCCEG LIISRYGPAW
REQRRFALST LKNFGMGKKS LENQISQEAG FLCSAFSCKE GHSFDPLFLI KKAVSNVIYS
LTFGERFDYD DEKFQRLVEI FQQAMKEETG FLPQLLNEVP FLLRIPGVPQ KVFQYQRASM
SLVDEILNKH KETWESTHIK DFTDAFLQEV EKTKEGVETS FTYENLRLVA VDLFSAGTET
STTTLCWAVL YMLLHPEVQR KVHEEIDKVI GRDRSPNMLD QANMPYTNAV IHEIQRYGDI
LPIGLPHMTY QDTELQGFFI PKDTVIITNL SSVLKDETFW EKPHQFYPEH FLDADGQFVK
REAFLPFSAG RRMCLGEQLA RMELFLFFTS LLQCFTFQLN RQENVIHDKS SEGKRKDKER
IDQVLCESWI PGCLVFLHSL PEEVKGSIVG SEDFLMMLRK MHQPRHHVQN LGS
//
