ID A0A151M2U3_ALLMI Unreviewed; 3203 AA.
AC A0A151M2U3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Lysosomal-trafficking regulator isoform A {ECO:0000313|EMBL:KYO18829.1};
GN Name=LYST {ECO:0000313|EMBL:KYO18829.1};
GN ORFNames=Y1Q_0009244 {ECO:0000313|EMBL:KYO18829.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO18829.1};
RN [1] {ECO:0000313|EMBL:KYO18829.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO18829.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO18829.1}.
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DR EMBL; AKHW03006780; KYO18829.1; -; Genomic_DNA.
DR STRING; 8496.A0A151M2U3; -.
DR eggNOG; KOG1786; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF86; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2411..2517
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2522..2824
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3014..3048
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 133..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1597..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3203 AA; 361516 MW; 5DF6829DDFDFA85C CRC64;
MGTSGREAQF EALVSDMSSA SNSLAREFLT DVNRLCNAVV QRAEAREEEE EETHMAVLGQ
YLVQGRGFNL LTMLNSIIDQ ELTCREELLT LLLSLLPLVW KIPVQEEKAI AGFNLPFTVD
VYLTKETNSG SLKSTQEKIS LEGNSPPSLQ PSGKIYPFSR KSRRQRKTTH RYSEVLQIYL
QTLPALFKSR VIRDLFLSCN GVNQMTELNY LDSVRVHSLK VFETLIFCLG DQQKDQAMPE
LEGLDSEKKE STLDPPASLC SQQIVSVPPS LSKFYAGLKG AYPKKKKSIS QDVHVNTINL
FLCVAFLCVS KEADSDRDSA NDSEDTSGYD STASEPLSHK LPCLSLESLV LPSPEHIHRA
ADIWAMCRWI YLYSSVFQRQ FHRLGGFEVC HKLLIMIIQK LSKNKEKQQE KKEGLFTENG
KNVNGSPRIE PVFKEALSHV TKKNKLASSE VHSLVENSEA TRPLVSEHIS NDHSFSVEQI
SGTPVHPELD ASERRENEWA FQSIRLLEAL LTICLHSVNN MQQKLEMETL HQNMCVEDIL
LEIRDQLTQA KVVETDLAKP LFDSLLRVAL GNFSADLDNS EEKTEKGQQA EKESVPQSGD
LSEETEESQC CSLKLFVEEE GYEADSESNP DDSETKDEGA DTKSEAGYTG PSSYSSDLIE
SLNQGELIYP EICLLELNLL LAGNPSLDVL AHVFESFLKI IRQKEKNASL LMHQGVVKNL
LGGFLNILTQ SDSNLYECQV VLVDLLDSLM SSRTSSEELT LLLRIFLEKT PCTEILLQGI
LKIVEANIYV SPLQYLTFPL LHIPNLSNSS SQKSASVLNS KAIGLLKRGK LSQSKKEADG
ENLTHQLLSS WHVAPIHLPL VGQNCWPHMS EGFSISLWFN VEHVQEMESP TEKGKKTKKR
SKPLILQDSN FDSSEESKPV GFENLSLRDK LVEDGCIHIV SLGSKALMIQ VWADLNTGAF
IFRMCIDPND EMKAGLLAQA ESPENVFRIG KWQHLVLTYL QQPEGKKNIH GKLSLWVSGQ
RKPDIGLDYA LPRKTGLSSD SNKTFCMLGH CTSSQEEMFR LAGKWHLGNL LLFNGAKIGP
EEAFYLYACG PDFTSVMPCK YGKTSFDYSK YISKEILQCE EIKEFFMTKK EVDVGPLIES
LAVVYTTCCP AQYTIYEPVI RLKSQVKSVP TQRPFSSKEV QSNELDSHHL KMLQPIECKT
LQGILHEIGG TGAFIFLFAR VVEISDSEET QALSLQLILS LTKYNQQRIQ EMENCNGYSM
IHQVLTKPKC IVGFRILKTL LEGCYSDEIL HINENGQFML DVDSSAVIQD VKLLEKLLLD
WKIWSKAQQG VWETLLVTLE ILIRADHHQQ MFNIKQLLKA QVVHRFLLTC QVLQEHKEGH
LASLPREVCR SFVKIIEEVL GSPPDLELLT LIFSFLLAVH PPTNTYVCHN PTNFYFSLHI
DGKIFQEKVQ SIMYLRNFSS GGKPVECSAF EVTSPAGFTA ALPEGGIASK VSVPQLIGSQ
VQERRCKSLP ASPTSSPHVH PKRLTGSLGK NIDHLLEAGG GRTNLQEKIT LMESSETLKR
VQEELFISSC ESAKTVCDSE LTSAEILVDI PKEEELSANA SESKGANADL KPNEDAGDTE
STLRRPDHLK GLPSFQKSQS NFPGLGLAFS AHSGPSTMSR WPSLTDKNVP PEDWEGLNFS
SVSEQTLKKS ESLDDRSTED FLVLICCGLY DLLRGVLLIL PDIMLEDVMD KFIQPDTLIV
LVNHPSPLIQ QGVIKFLDAY FNRATREQKE KFLKNRGFSL LANQLYLHQG TQEVVECFLE
MLFGRSLGLD EEFDLEDVKN AGLFQKWCII PVLGLIENSL YDNVLLHNSF CLLLQIINSC
SKVADMLLDN GLLYVLCNTL AALNGLEHNI PLNDYKLLAC NIQQLLVAVT IHACSSSGSQ
YFRVVEDLLV LLGHLQNSNN ERTQNMAITL QFRVLHAAIE LIKTTANQDS QEQANSLHLP
ATCHHAMLQK RKSIAGSRKL SIAQSDTLLM KMRSVASDEL NMMIQRRMSQ ENPVRATETE
FVQRLQRLTV LAVNRLIYLE STQDCLYVLG APETTIQSRL SASHLEASEE EEQRELPNNT
NPFLKEMIKI LIEGIKVSIS TSRMSTPRHQ WKRVLWSCKD TFRTQLGRLL VNVLSPARPL
QERKLALDIV CETNHQEILR DCLSPTLHHG PKLALYLYEL MHDHKGELTE EEQESSRIFL
DALKSCGYKS IPSTAPLKPD IIKAMKEDQK KYEAEEGVNK AAWEKTMTNN RQNLFQRLDA
KSKDISKIAA DITQTVSLSQ GMERKKVIQH IRGIYKADLS ASRHWQELVQ QLTHDRALWY
DPVYYPTSWQ LDPTEGPNRE RRRLQRCYLT IPNKYLLPDR QKQEEVIKPP LSYLFEDKTH
SSHSSTVKDK AASEHIRVNR RCISVAPSRE TAGELLLGKC GMYFVQDNAS ETIENSSFHG
ETEPASFSWT YEEIKEVHKR WWQLRDNAVE IFLTNGRTLL LAFDNTKVRD DVYHNILTNN
LPNLLEYGNI TALTHLWYTG QITNFEYLTH LNKHAGRSFN DLMQYPVFPF ILSDYTNETL
DLNDPSVYRN LVKPIAVQSK EKEDRYVDTY KYLEEEYRKG AREDDPMPPV QPYHYGSHYS
NSGTVLHFLV RLPPFTKMFL AYQDQSFDIP DRTFHSTNTT WRLSSYESMT DVKELIPEFF
YLPEFLVNRE GFDFGVRQNG ERVNHVNLPP WARNDPRLFI LIHRQTLESD HVSQTICHWI
DLVFGYKQKG KASVQAINVF HPATYFGMDV SAVEDPVQRR ALETMIKTYG QTPRQLFYTA
HISRPGSRLI MEGELPAAMG LLVQFAFRET REHTKEIVYP SPLPWIKGLK WGEYVGSPSA
PDPVVCFSQP HGERFGSLQA LPTRAICGLS RKFCLLMIYS KEQGVRSMHS TDIQWSAILS
WGYADNILRL KSKQSEPPVN FIQSSQFHQV TSCAWVPDSC QLFTGSKSGV ITAYVNKFTS
STPSEIEVES QVHLYGHTAE ITSLFVCKPY SIMISVSKDG TCIIWDLNRL CYVQSLAGHK
SPVTAVSASE TTGDIATVCD SVGGGSDLRL WTVNGDLVGH VHCRESICSV AFSNQPEGVS
VNVIAGGLEN GVVRLWSTWD LKPVREITFS KSNKPIVSLT FSCDGHHLYT ANSDGNVIAW
CRKDQQRLKL PMFYSFLSNY AAG
//