ID A0A151M4M5_ALLMI Unreviewed; 780 AA.
AC A0A151M4M5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sodium/glucose cotransporter 2 isoform B {ECO:0000313|EMBL:KYO19456.1};
GN Name=SLC5A2 {ECO:0000313|EMBL:KYO19456.1};
GN ORFNames=Y1Q_0010413 {ECO:0000313|EMBL:KYO19456.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO19456.1};
RN [1] {ECO:0000313|EMBL:KYO19456.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO19456.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000256|ARBA:ARBA00006434, ECO:0000256|RuleBase:RU362091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO19456.1}.
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DR EMBL; AKHW03006625; KYO19456.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151M4M5; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 1.20.1730.10; Sodium/glucose cotransporter; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR NCBIfam; TIGR00813; sss; 1.
DR PANTHER; PTHR11819:SF145; SODIUM_GLUCOSE COTRANSPORTER 2; 1.
DR PANTHER; PTHR11819; SOLUTE CARRIER FAMILY 5; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00474; SSF; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..780
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007584737"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..277
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT REGION 696..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 84170 MW; E7402D511D906D50 CRC64;
MDTALRLLAL LLLGGAVAPH KESWCYEDPE CGPATWVKLG HCNGTRQSPV ELSTHDAVPD
PRLGPVALSG YGDARRLRSL HNTGHTVEVQ LAEGLMLSGP GLPGHYRAQS FHLHWGQGEA
RPGSEHLLDG RRFSMELHVV HTKENLTLHE AMDDPEGVAV LAFFVQASSH ARPTRHWEAF
VNQLKHVEKK GEREELDGMF SLGGLMEAVN LGRYFRYHGS LTTPNCNEVV IWTVFAEPIM
VPPGVPTGER EGSMEPGTVA PSPVLSPYDM GVIAAYFLLV VGVGLWSMCR TSRGSVGGYF
LAGRNMSWAP VGASLFASNI GSGHFVGLAG TAAANGLAVA GFEWNVITMP EYLKKRFGGQ
RISLYLSVLS LFLYIFTKIS VDMFSGAIFI QQALGWDIYL SVIALLIITT IYTITGGLAA
LMYTDVVQTL VIVTGAFVLM GFAFWEVGGY TGLVAGYMEA VARHPDPATH NMSAACYRPR
PDAFHLLRDP VSGDLPWPGL LVGLTINAGW YWCTDQVIVQ RCLAGRSLVH VKGGCILCGY
LKILPMFLMV LPGMISRVLY PDEVACAVPE ACMAACGNPI GCSNIAYPKL VVSLLPAGLR
GLMLAAMLAA LMSSLASIFN SSSTLFTMDV YRRLRPCAGP RELLLAARGG QLFDYIQAVG
SFLAPPVAAI FTLAVFVPRV TEALQGLVFG LRDRRHNPEA EEGPEPPAPA LHGPVPAPSG
SPGCWARLCG EGGTRDPPTL ASPPLDKPHP LEDTPRQRRL VDTHALVMMG VACFLWGYFA
//
