ID A0A151M6T3_ALLMI Unreviewed; 1271 AA.
AC A0A151M6T3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN Name=LARS {ECO:0000313|EMBL:KYO20215.1};
GN ORFNames=Y1Q_0010774 {ECO:0000313|EMBL:KYO20215.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO20215.1};
RN [1] {ECO:0000313|EMBL:KYO20215.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO20215.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO20215.1}.
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DR EMBL; AKHW03006437; KYO20215.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151M6T3; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07959; Anticodon_Ia_Leu_AEc; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00395; leuS_arch; 1.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 21..103
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 185..756
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 795..906
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 1271 AA; 145334 MW; 42FC2C6446B329B6 CRC64;
MAERKGTAKV DFLKKIEKEI QCKWDDERVF EFNVSDLGSQ RSKGKYFVSF PYPYMNGRLH
LGHTFSLSKC EFAVGYQRLK GKNCLFPFGL HCTGMPIKAC ADKLKREMEL YGCPPEFPDE
EEEEEEASVK KEEEVVIKDK AKGKKSKAAA KTGSSKYQWG IMKSLGLSDE EVVHFSEAQH
WLDYFPPLAI QDLKSMGLKV DWRRSFITTD INPYYDSFVR WQYLKLKERN KIKFGKRYTI
YSPKDGQPCM DHDRQTGEGV GPQEYTLIKM KVLEPYPVKL SGLKGKNIFL VAATLRPETM
FGQTNCWVRP DMKYIGFETV NGDIFICTQR AARNMSYQGF TKDNGVVPVV KELMGEEFLG
AALSAPLTSY KVIYALPMLT IKEDKGTGVV TSVPSDAPDD IAALRDLKKK QALRGKYGIK
DEMVLPFEPV PIIEIPGYGS LSAPLVCDEL KIQSQNDREK LTEAKERVYL KGFYEGIMLV
DGFKGRKVQD VKKVIQKMMV DNGEAMVYME PEKQVISRSA DECVVALCDQ WYLDYGEVNW
KKQASECLTN LETYCEETRR NFEATLAWLQ EHACSRTYGL GSRLPWDEHW LIESLSDSTI
YMAYYTVAHL LQGGDLRGQG ESQLGIRPHQ MSKEVWDYIF FSKAPFPKTD IPKEKLDKLK
DEFEFWYPVD LRASGKDLVP NHLSYYLYNH VAMWPDERDK WPVAVRANGH LLLNSEKMSK
STGNFLTLNQ AVDKFSADGM RLALADAGDT VEDANFVEAM ADAGILRLYT WVEWVKEMLA
NKDSLRNGPA NTFNDRVFAS EMNAGILKTD QNYEKLMFKE ALKTGFFEFQ AAKDKYRELA
IEGMHKDLVF QFIEVQTLLL APICPHLCEH IWSLLGKPDS IMKASWPVAG PVDDILIRSS
QYLMEAAHDL RLRLKNYMTP AKGKKGSKEA PQKPSHCTIY VAKNYPPWQH NTLSVLRKHY
QVNGGQLPDN KVIAMELNTL PELKKYMKKA MPFVAMIKEN LEKKGPQVLD LELEFDERAV
LMENIVYLTN SLELDHIEVK FASEAEDKIK EDCCPGKPFS TFRMEPSVSV FLVNPQPSNG
HFSTKIEVRQ GDSRDAIIRR LMKMDRGIKD HSKVKLMRFD DPVLGPRRVP VLGKEDAEKT
LILEQAVFNV DLAEKRIYIT ENGLTKDIDL QKALAQHQSD FKRFGCRCLS ATEEVLLPEM
QSPLILSLTA PEDGAFFLDG PRCLWYIVQS MSRMQPCKTL WGVPVFPVAT RFHLSIKSWR
QRKAQNTRNP L
//
