ID A0A151M734_ALLMI Unreviewed; 1448 AA.
AC A0A151M734;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:KYO20250.1};
GN Name=RAD50 {ECO:0000313|EMBL:KYO20250.1};
GN ORFNames=Y1Q_0010800 {ECO:0000313|EMBL:KYO20250.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO20250.1};
RN [1] {ECO:0000313|EMBL:KYO20250.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO20250.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}.
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO20250.1}.
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DR EMBL; AKHW03006437; KYO20250.1; -; Genomic_DNA.
DR STRING; 8496.A0A151M734; -.
DR eggNOG; KOG0962; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR Pfam; PF13558; SbcC_Walker_B; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 635..734
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT COILED 203..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 389..421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 450..628
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 740..815
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 846..939
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 973..1051
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 681
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 684
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 1448 AA; 168293 MW; 3C1818493D337143 CRC64;
MSKIEKMSIL GVRSFGVEDK DKQIISFFNP LTILVGPNGA GKTTIIECLK YISTGDFPPG
TKGNSFVHDP KVANETDVRA QIRLQFRDVN GELVAVQRSM VCTQKGKKTE FKTLEGVITR
TKHGEKVSLS SKCAEIDREM ISSLGVSKSV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF
SATRYIKALD TLRQVRQKQG QKVKECQTEL KYLKQNKEKA REIQDQLNSR ETQLAVSKEN
VKSIENQLDP LKTRLAEIER NLIKVMGLDN DIKALDSRKR QMEKDNRDLQ QKMEKVFQGT
DEQLRDRYQN HQRIVKEKER RLADCQRDME RVSKECLRFN REKSDLLVEQ GRLQLQADRH
QEHIRIRDSL IQTLAAQLEF DGFERAPLNE RQISNFNKLV KERQEKEAET ANQLMREFSA
KEVVKQKQID EIRDKKTGLE STIVLKSDIQ DKKKLELKNV KSELQQLEGS SNRLLELDQE
LAKAEHELDK AEKNSNVEAL EQEVQVLQIE KEDLDKVLRK LDQEMEQLNL HTMTITQMDM
LNKDKADKEE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HAKTREINQT RDKLAKFNKE
LASAEQNKNH ISTELRKKEE QLSGYEEKLF DVCGSQDFES DLYKLQDEIE KSSKQRAVLA
GATAVYSQFI TQLTEEDQAC CPVCQRVFQT ETELQDVISD LQSKLRLAPD KLKTTESELK
RREKRRDEMM GLKPIRQTIV ELKEKDIPDL RNKLQNVNRD IQRLKTDIEE VETLLHTVIP
EEESAKACLQ DITLMERYQI DLRDVERKIA QHAAKLLGVD LTRTVQQVSQ EKQGKKHLWD
TVTSKIELNQ KLKQAQQNEI QQLKSTLNEL KAEKLHISGR MQRRQQLEEQ TVELSTEVQS
LSREIKEAKE QIFPLDATLE KLQQEREDLI NKKNTSNKTM QDKINDTKEK VKTIHNYMKE
IENYIQDGKE DYKKQKESEL DEVKTQLADC ENRKERINKE MGTIRQDIDT QKIQERWLED
NLTLRKRNEE LKGVEEEIKQ HLKELGEMKA QQMKTQRGFE EEIIRFKKEL RESQFKDAEE
KYRDMMIVMR TTELVNKDLD IYYKALDKAI MTFHSMKMEE INKIIRDLWR STYRGQDIEY
IEIRSDADEN VSASDKRRSY NYRVVMIKGD TALDMRGRCS AGQKVLASLI IRLALAETFC
LNCGILALDE PTTNLDRENI ESLAHALVEI IKSRSQQRNF QLLVITHDED FVELLGRSEY
VETFYRIKKN IDQCSEIVKC SVPCGESRVA QISTKDGTVN YPEKLCQAAK ALETVTKCKT
DYQAIITNLF EVYGYRVSCK QMNVSDIFED PKSMTSASSA TKSTVPPCSP PILEKNQSEM
LCKAAAVLTK AQCFCQEHRH LKAIRVNLLE LTHTVRCPVN TTSNTTLHGF LERLTDLSQM
IMMQNPVH
//
