ID A0A151M784_ALLMI Unreviewed; 628 AA.
AC A0A151M784;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Kelch-like protein 3 {ECO:0000256|ARBA:ARBA00023889};
GN Name=KLHL3 {ECO:0000313|EMBL:KYO20331.1};
GN ORFNames=Y1Q_0010859 {ECO:0000313|EMBL:KYO20331.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO20331.1};
RN [1] {ECO:0000313|EMBL:KYO20331.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO20331.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the KLHL3 family.
CC {ECO:0000256|ARBA:ARBA00035639}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO20331.1}.
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DR EMBL; AKHW03006437; KYO20331.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151M784; -.
DR STRING; 8496.A0A151M784; -.
DR eggNOG; KOG4441; Eukaryota.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18513; BACK_KLHL3; 1.
DR CDD; cd18339; BTB_POZ_KLHL3; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030578; KLHL3_BACK.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF451; KELCH-LIKE PROTEIN 20; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 91..158
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 628 AA; 69597 MW; F95ED3FD3EBDA690 CRC64;
MSNQGNMDLH RLFLKHFTLF SVTCSCDAPF QMTPVLDLSV SDGECISVKP SSRSPEAAED
EKDQRTVTIN PSHMKKAFRV MNELRSKQLL CDVVIVAENV EMEAHRIVLA ACSPYFCAMF
TGDMSESKAK KIEIKDVDGQ TLSKLIDYIY TAEIEVTEEN VQVLLPAASL LQLMDVRKNC
CDFLQSQLHP TNCLGIRAFA DVHACTELLQ QANAYAEQHF PEVMLGEEFL SLSLDQVCSL
ISSDKLTVSS EEKVFEAVIS WINYEKESRL EHMAKLMEHV RLPLLPRDYL VQTVEEEALI
KNNNTCKDFL IEAMKYHLLP LDQRQLIKNP RTKPRTPISL PKVMIVVGGQ APKAIRSVEC
YDFEEERWDQ VAELPSRRCR AGVVFMAGNV YAVGGFNGSL RVRTVDVYDG VKDQWTSIAS
MQERRSTLGA AVLNDLLYAV GGFDGSTGLA SVEAYSYKTN EWFFVAPMNT RRSSVGVGVV
EGKLYAVGGY DGASRQCLST VEQYNPATNE WTYVADMSTR RSGAGVGVLS GLLYATGGHD
GPLVRKSVEV YDPGANTWKQ VADMNMCRRN AGVCAVNGLL YVVGGDDGSC NLASVEYYNP
VTDKWTLLPT NMSTGRSYAG VAVIHKPL
//
