ID A0A151M8W6_ALLMI Unreviewed; 1050 AA.
AC A0A151M8W6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DIS3-like exonuclease 1 {ECO:0000256|ARBA:ARBA00016366};
DE EC=3.1.13.1 {ECO:0000256|ARBA:ARBA00012163};
GN Name=DIS3L {ECO:0000313|EMBL:KYO20953.1};
GN ORFNames=Y1Q_0001285 {ECO:0000313|EMBL:KYO20953.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO20953.1};
RN [1] {ECO:0000313|EMBL:KYO20953.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO20953.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO20953.1}.
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DR EMBL; AKHW03006295; KYO20953.1; -; Genomic_DNA.
DR RefSeq; XP_014461496.2; XM_014606010.2.
DR AlphaFoldDB; A0A151M8W6; -.
DR STRING; 8496.A0A151M8W6; -.
DR GeneID; 102559473; -.
DR KEGG; amj:102559473; -.
DR CTD; 115752; -.
DR eggNOG; KOG2102; Eukaryota.
DR OrthoDB; 945235at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR PANTHER; PTHR23355:SF30; DIS3-LIKE EXONUCLEASE 1; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exonuclease {ECO:0000313|EMBL:KYO20953.1};
KW Hydrolase {ECO:0000313|EMBL:KYO20953.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 462..814
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT COILED 993..1025
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1050 AA; 119897 MW; D5FAC2524728E96E CRC64;
MQRAEKVVQL RGPPGRAVRV VREHYLRPDV PCRSALCRAA CARDGKLLSD DVTHYVVPDW
KVVQDYLEIL EFPELKGIIF MQTACQAVQH QRGRRQYNKL RNLMKDARHD CILFANEFQQ
HSYLPRERGE SMEKWQTRSI YNAAVWYYNH CLGQMPVVMV TEDEDAIRQY GNETEGVFVI
SFKNYLDNFW LDLKAAHELF DSILQSRRER ESESQENNGK EYPEHLPMEV LEAGIKSGRY
IQGILNVNKH RAQMEAFVRL QGASRKKKDL QSDILIYGTK ARNRAIHGDV VAVELLPLHE
WKGRTVALCE NEADEKASGD TSSEPMPTGR VVGIIQKNWR DYVVTFPSKE ESQTQGKNVQ
KILVTPWDYR IPKIRISTQQ AEALQDCRVI VRIDAWESTS VYPNGHFVRV LGRIGDLEGE
IAAILVENGI SVAPFSEVQM SEMPVSTLEN PWRVNPEEEL KRVDLRDTHL VFSIDPKGCE
DVDDTLSVRA LANGNLELGV HIADVTHFVP VNSYTDLEAR ARATTYYLAD RRYDMLPSVL
SADICSLLSG VDRYAVSVMW ELDKTSYEIQ RVWYNRTIIR SAYKLHYEAA QALLDGDLSG
VDEILELKEL DERTRQQKLN ELVWAIGKLT DIARHVRAKR DSCGALELEG VEIRVLLDDK
KNIHDLIPKQ PLEVHETVAE CMILANHWVA KKIWEKFPQQ AVLRQHPPPR QEFFSELREC
ASAKGFVIDT WSNKALADSL DRANDPLDPI VNKLLRSMAT QAMSNALYFS TGSCSEEEFH
HYGLALDKYT HFTSPIRRYA DIAVHRLIVA ATLKDTKENI KDSLFSNKDL DELCSHINNR
NRAAQRAQKQ STELFQCMYF KDKVAEADER CVADGVIYSI RTNGVLVFVP RYGIKAPAYL
KNKEGLVISC QSDGSCEWKP GFLQHFQNRI TSTTTAGESV TLSLFEHITV KILGQSSRCH
ADTLKLEIVS NTPYETANAD VSQNSHVMKS DLVKEVTKSA EEAQLAQERA RAEIIQEEYQ
EYCQTKGTSL YQLLEEIRDL DLLDVTEHEV
//
