ID A0A151MC37_ALLMI Unreviewed; 1110 AA.
AC A0A151MC37;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=TRIM66 {ECO:0000313|EMBL:KYO22062.1};
GN ORFNames=Y1Q_0000680 {ECO:0000313|EMBL:KYO22062.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO22062.1};
RN [1] {ECO:0000313|EMBL:KYO22062.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO22062.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO22062.1}.
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DR EMBL; AKHW03006283; KYO22062.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MC37; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19811; Bbox1_TRIM66; 1.
DR CDD; cd19794; Bbox2_TRIM66-like; 1.
DR CDD; cd05502; Bromo_tif1_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037372; TRIM66_Bbox1_Znf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR PANTHER; PTHR45915:SF7; TRIPARTITE MOTIF-CONTAINING PROTEIN 66; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 88..142
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 165..211
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 230..266
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 897..944
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 984..1056
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1080..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 125105 MW; 7C30502ADD0E8D35 CRC64;
MEREGNELSR DRLTRRRERN LARSRNAAVT KLICAGTTET VAMDEESQMI STGFSPAEAL
LKWEGIISPL DIKLWTRKME SFDLLRNCLV CKWELKGRDP RLLPCLHSFC KDCLPDLIQG
YRYTPTEKEI LYEGILSCPV CKQPCFAKDV AENYFLKDFP TANPAMARSC SVCKEKRPAH
SLCTTCNKWL CSSCTEEHRH GKETGDHFLS VSLKSCSGTE GGASEFTLCC PMHSQEPLKL
FCETCDVLTC RSCLLTEHKE HRFKHLEEAL QNQRVILENV TAKVEEKRTG IQVSAKQIED
RLFEVKHLHK KVENQIKMAK MVVMNEINKR TNSLLEQLER ITSERKQKLE QQLQGIVVLN
RQFEHVQNFI NWAVCSKNNI PFLFSKELIV FQIQRLLETN CSTDVGPPLK IRFTWDPSFW
TKQLSNLGGL TLEGGHISHS DVLAYGSAQG LHTPLYHGHH SPAPQLEPIS NHSHQFPVPV
QCPTPAQGQP SLQLNQTKQP QHVQQTIVGQ INYIVRQPAP VQQQIQDEVQ QRCEDSAELD
GQKPVLPLDR NVMPPVLQPS SEEFIAGSHS PESTLQHPSL NPVRKRSASL SIVGFSNTLE
MELSSTRLTR SADPQMQGVS AVTFGQSQSM PHASDIQPEP VPSYSLASDR AINDLSPGTT
NNLATGDVLL GNAKYKLENE DFSTTSDPLG NDSATTSPST INELALPMQK MLEEPINLSV
KKSQQCASPS TPINNAPCLL SASVKQLSNE KDFSNCEQEH FEMDVKNNQN ISTYAKELKI
PYVRLERLKI CMSESGELPV FKLQPQKSEQ DGTFLLIIEC GTQSSSMAIK VNQDNPSEGK
IHKLGGSENR KIPINPPSGQ VPSPFVDIRP VDHKLNNGIP STRKPPLPQE ISPIENEDFC
AVCLNGGELL CCDHCPKVFH LSCHVPALLS FPVGEWVCTL CCNPLKPEVE YDCENTRYRR
INKALHGLDD CDQKKCEKLV LFLFCSSLSL PFHEPVSPLA RHYYQIIKRP MDLSIIRRKL
QKREKSHYSA PEQLVADVRL MFWNCAKFNY PDSEVAEAGQ CLEVFFEGKL KEIYPDKHFP
LMQQEDSDSE EESEKTKRTM FQPSNSLPQV
//
