ID A0A151MDB0_ALLMI Unreviewed; 647 AA.
AC A0A151MDB0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Transmembrane protease serine 7 isoform B {ECO:0000313|EMBL:KYO22479.1};
GN Name=TMPRSS7 {ECO:0000313|EMBL:KYO22479.1};
GN ORFNames=Y1Q_0003045 {ECO:0000313|EMBL:KYO22479.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO22479.1};
RN [1] {ECO:0000313|EMBL:KYO22479.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO22479.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO22479.1}.
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DR EMBL; AKHW03006231; KYO22479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MDB0; -.
DR eggNOG; KOG3627; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24252:SF8; ACROSIN; 1.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Hydrolase {ECO:0000313|EMBL:KYO22479.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:KYO22479.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:KYO22479.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..207
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 343..452
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 552..647
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 464..482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 476..491
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 505..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 525..540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 647 AA; 72729 MW; 776E15FD11207BF9 CRC64;
MIQSVASKRV SVVYSIPSPD DCECVSGQSP NLYWVQSSEE ESSFLKYSFL KRLRWHLGIL
PIISLAVTVF VLVLHYSLSP AFSFIYIGGS VEIPNLTYTS DLTDPKSQKF ILQAEMIQSY
FAEFYESSTL GKYYLNSVVA AFSEGEDGLK VYCWSIFWAP QDITGSFKKL ISLKQKEIIR
KQVPWDVNSS AESFLVEENF DLFTMDLFVT DATEYDVTLK SVSFDLYAKP GNNRSLTLVN
PKKSFYQWRL RVPSNYVVRL VILTLHGVTP GSCASHRLSA YDFLLPLQNK IITRWCGVPG
AWNPPIVRLT SSSNVMLVTF SLDKRKENSI LKAYFQAVPK IVCGGRYISW NGTVSSPYYP
SYYPPSIDCS WIIRAPLPGY KLSLKILVIQ IQEKTPGSSK CDKDWLEIDG VRYCKAIAEG
QRNKDYGYSV AISFHSDELV THRGFYIEYK AFSYMDLCPR QFKCTDGTCI PLNNQCDGRQ
DCSDGSNELD CGCSPEESNC ASKNCSPYAY KCSNGKCSMK PNPECDGIRD CADGSDEVNC
ACGKSQFKKN RIVGGEDARS GKWPWQASLQ MGTYGHICGA SVISNRWLIS AAHCFLDSDS
IRYSVPSGWK AYMGIRIMSK NSNHVAMRSI KRIVVHPRST CQNIARS
//
