ID A0A151MED4_ALLMI Unreviewed; 1487 AA.
AC A0A151MED4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Interferon-induced GTP-binding protein Mx isoform B {ECO:0000313|EMBL:KYO22863.1};
GN Name=MX1 {ECO:0000313|EMBL:KYO22863.1};
GN ORFNames=Y1Q_0003328 {ECO:0000313|EMBL:KYO22863.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO22863.1};
RN [1] {ECO:0000313|EMBL:KYO22863.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO22863.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO22863.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03006231; KYO22863.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd08771; DLP_1; 2.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR039477; ILEI/PANDER_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF237; INTERFERON-INDUCED GTP-BINDING PROTEIN MX; 1.
DR Pfam; PF01031; Dynamin_M; 2.
DR Pfam; PF00350; Dynamin_N; 2.
DR Pfam; PF02212; GED; 2.
DR Pfam; PF15711; ILEI; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 2.
DR SMART; SM00302; GED; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00410; G_DYNAMIN_1; 2.
DR PROSITE; PS51718; G_DYNAMIN_2; 2.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 257..530
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 894..1166
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 1399..1487
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 810..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1487 AA; 168469 MW; 53A7F67BE90D835B CRC64;
MRPVAGNLVK LSGLMLASGC AWYLGYVFAD IIPEDTVSIA IQNLQNIGER PVIKAPLPKR
QKCDHWSPCA PRSYAYRLLS GGGKEKMAKI CFEDELLISE QRGNVGRGIN IAIVNYKTGK
VVSTKFFDMW EGDFSGEMTA FIKDAPQGSL LLMVTHDDGS ARLKDDGKKA IEELGSKEIR
NMKFRSSWVF IAAKGFKLPD NIEKEKNQQQ TRSYKKFPQL KGINLKAETF LGSEYEEKVR
PCIDLIDSLR ALGVEKDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG IVTRCPLELK
LKKSHVPEDW KGKIKYKEVE QELYYPSEVE KEIRNAQDLM AGKGVGISQE LISLEISSPY
VPDLTLIDLP GIARVAVGNQ PQDIGNQIIK LIKTYITKQE TINLVVVPSN VDIATTEALK
MANEVDPNGE RTLGILTKPD LVDKGTERTV VDIVRNLSVP LRKGYMIVKC RGQQNINDKL
TLASAITRER EFFEEHEHFS ILLEEKKATI PLVAERLTQE LIDHINKSLP NLEKQIQHKL
QVASKKLQKC GLGIPETAEG KMLVLIEKIK LFNQDIMNAV QGEEVCTNKE NINNNALNMK
DLMKEEILKF ENQYRGRELP GFINYRTFET IVKEQIGLLI IPATTVLKNT TDLVRDAFTE
IAVKHFDNFL ALHRAAKSSI EDLKQTQEEA AENMIQTQFK MERIVYCQDR LYSGALEEAR
RLPQSTQRFH SSYTLDSPKQ YSINEMTYHL TAYFKGAGNR LSTQIPLIIR SYVLKDYGEK
LQNAMMQLLQ DKDQFNILLK ERKDISPIPV VSPLSTTTPP PERNKSIQQG LATEHHIESE
KNRHQREKTQ QGEIYASEEK NKKEENTLYN QYEMRIRPCI DLVDSLRALG IEKDLALPAI
AVIGDQSSGK SSVLEALSGV ALPRGSGIVT RCPLELKLRK TPEQVWKGKI SYQGMEEKLE
NPMQVEKAIR KAQNIIAGEG VGISQELISL EISSPDVPDL TLIDLPGIVR VAVGNQPTDI
GEQIKNLIKK FIVKRETINL VVISSNVDLA TTEALKMAQE VDPEGERTLG ILTKPDLLDK
GTEHTVVDIV QNRVILLRKG YMMVKCRAQQ DIQNNITLAS AIQEERKFFE NHKYFGDLLK
EKKATIPLLA EKLTNELVIH ISKSLPALEE RVSEELRKAI EKLQKNCGSV PEEESEKMML
LLKKIKSFNT DITNLIRGEE DLYETEIRMF SKIRKEFQEW GRILDVRSDK VKRSIQEDVW
RFDNQYRGRE LPGFINYKSF EDIVKKYIRE LEGPALEVLS KVIDIVGQSF TEVATANFPE
FFNLTRAAKG RIEDIKMQQR AEAEKMIQNQ FKIEQIVYCQ DNFYRKALRD TNVNNVEEAL
KTLKFQDVNG IVPDKSPSTV ELACHLEAYF NGAGHRLSSL IPLIIQSFTI RDYGDKLQNA
MLQLLQEKQL LDCLLMEHKD VAAERNFLMQ QINRLRKAQL YLLKVSV
//
