ID A0A151MF08_ALLMI Unreviewed; 1223 AA.
AC A0A151MF08;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Apical endosomal glycoprotein {ECO:0000313|EMBL:KYO23091.1};
GN Name=MAMDC4 {ECO:0000313|EMBL:KYO23091.1};
GN ORFNames=Y1Q_0005553 {ECO:0000313|EMBL:KYO23091.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO23091.1};
RN [1] {ECO:0000313|EMBL:KYO23091.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO23091.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO23091.1}.
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DR EMBL; AKHW03006215; KYO23091.1; -; Genomic_DNA.
DR RefSeq; XP_014458150.1; XM_014602664.2.
DR AlphaFoldDB; A0A151MF08; -.
DR GeneID; 102565521; -.
DR KEGG; amj:102565521; -.
DR CTD; 158056; -.
DR eggNOG; KOG1095; Eukaryota.
DR OrthoDB; 2905895at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR CDD; cd06263; MAM; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF101; RT07201P-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00629; MAM; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00137; MAM; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS50060; MAM_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1223
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585096"
FT TRANSMEM 1155..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..227
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 275..435
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 487..649
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 659..813
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 815..971
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 973..1140
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DISULFID 235..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 242..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 459..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 471..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1223 AA; 134202 MW; 4393D0DF21B7E1DE CRC64;
MPGSLFLWVL VLSAGPHRLG QSIFINRCSS PAEKVCDFVC DCRDCSDENQ CGYHKESATL
GTPFTCDFED GNCGWQDVST SAYRWGRNHA SISTGRTGPH SDHTRSTNLG WYMAAEMSRG
KLAVTARLRS PVMRQAASTC EIHAWYHLWR AGFNGTALPA LQMELTHANE TVTLWQSPES
SVYAWRKLVA YPGRVPGEFQ ITFSSTQSFL QLRDLAIDDI EFRNCGLPQL MSQVCGPEEQ
KCQRGSCVGK DRFCDGSDDC GDGSDESVLE CKSFRVCSFE ADLCGWKTVP GLLTWNRDTG
LDVVTLHGQP TRDHSKNSKA GYFLHVSYNQ TDLMKNLARL TSPVFQATGN SFCSLTFYSY
LYGSATNSIN IYYVANATQT LVRGRTGDLG DYWFREKVDF NVDKDFEIVI EGVIGTGKKG
HIALDDLILS PDCKQAAGKQ AIVVPETNSS CSPPENFVCD DGECISQELA CDFAVACKNS
SDEKFCGDTD FEAGSGGWRD ASVGQLQWVT MRASEALSPG TDHTTSTSAG SYLAVQRAPG
QMVTAAKART PPLGPSGLAC SLEMFYWLQS DPQGFIAVGT VDHALRMHRL VWYMQGNGSM
EWKKVTVPLG KRPRPFQVEL IGLVSPQGLA VPSVASVAVD DVKFVNCDPH VVPQEAIELS
CNFEKGLCGW YQDQNDDFEW VRGTGQGLGS DHTTGHGFFM AMDPSAQEAR GLSARLLTYL
LDPAAEIQCF LFWYRMDGPQ IGTLNLKIKH DGEAETVLWT RTGTQGSAWH LGSVTLHHHP
QQKYQLIFEA LRDGYLGHVA LDDLSVKPGT CRAQEHCSFE ASACGFTASG EHSWARQSNA
TGTAVTGPST DHTTGTARGY YMIINTSKSS LPRAATLASE LYVPLTRTQC LTFWYHLSTD
SGSLNIHMEE QGARRRLFSV SSMQGDAWHY GSVAVQADGE WKVIFEAVGA GREQSYIALD
DLHLKDGSCP EPGSCDFELD TCGWSSSSDP HLRGFAWGWK SGVSPSKYPG PQEDHTLGTK
EGHYAYFDAS VLGPGGSRAL LVSEHLPATT GACLQFWYHM DFLVHFYSGE LRVKLYSPAG
QLMVWSTGGH QGQGWMNRTI PLQSPEEFQI VFEVTNGAWP IGGTIALDDV KYRDGQGCNL
DRMLPVGDKT PTKGFLAAVA VGSILALIVL MALAMSLRYW LKKSASLSRT ENSITSPGFD
NITFSDDSII ISQRHKEGEE MND
//
