ID A0A151MJB3_ALLMI Unreviewed; 5107 AA.
AC A0A151MJB3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 03-MAY-2023, entry version 20.
DE SubName: Full=E3 ubiquitin-protein ligase UBR4 isoform A {ECO:0000313|EMBL:KYO24559.1};
GN Name=UBR4 {ECO:0000313|EMBL:KYO24559.1};
GN ORFNames=Y1Q_0023250 {ECO:0000313|EMBL:KYO24559.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO24559.1};
RN [1] {ECO:0000313|EMBL:KYO24559.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO24559.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO24559.1}.
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DR EMBL; AKHW03006061; KYO24559.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 2.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1600..1673
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 1600..1673
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 540..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1677..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2610..2636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2654..2690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2759..2893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3265..3310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2614..2636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2759..2817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2854..2876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3265..3289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3290..3309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5107 AA; 566474 MW; 39E72D98E435CD60 CRC64;
MAASGGGAAE PGWEVAVRPL LSASYSAFEL KELPQLLASV IESESEILHH DKQYEPFYSS
FVALSTHYIT TVCGLIPRNQ LQSVAAACKV LIEFSLLRLE NPDEACAVSQ KHLILLIKGL
CTGCSRLDRT EIITFTAMMK SAKLPQTVKT LSDVEDQKEL ASPVSPELRQ KEVQMNFLNQ
LTSVFNPRVT ASPSLAPETQ VEGESEDQAS TDQASAAKTK SIFIAQNVAS LQELGGSEKL
LRVCLNLPYF LRYINRFQDA VSANSFFIMP ATVADATAVR NGFHSLVIDV TMALDTLSLP
VLEPLTPTRL QDVTVLALSC LYAGVSVATC MAILHVGSTQ QVRTGSTSSK EEDYENDAAT
IVQKCLEIYE MIGQAISNSR RAGGEHYQNF QLLGAWCLLN SLFLILNLSP TALADKGKEK
DPLAALRVRD IIARTKEGVG SPKLGPGKGH QGFGVLSVVL ANHAIKLLTS LFQDLQVEAL
HKGWETDGPP AVLNIMAQST SIQRIQRLID SVPLTNLLLT LLSTSYRKAC VLQRQRKGSM
SSDASASTDS NTYYEDDFSS TEEDSSQVKS PNKQTTGENG NILASRKDPE LFLSLASNIL
NFITTSMLNS RNNFIRNYLS VSLSEQHMAT LASIIKEVDK DGLKGTSDEE FAAALYHFNH
SLVTSDLQSP TLQNTLLQQL GVAPFSEGPW PLYIHPQSLS VLSRLLLIWQ HKASAQGDPD
VPECLKVWER FVSTLKQNAL QGALPNDTED LNVEHLQLLL LIFHNFSEKG RRSILTLCIQ
TILDLTVKMD SQLQSVPLIL ARLLLVFDYL LHQYSKVPMY LFEQVQYNLL TPPIGWVSGS
QESSRRTAIP IYHGFKEVEE NWTKHCSSDA VPQPRFYCIL SPEASEDDLN RLDNTVCEVL
FSRIVKYDEL YAALTSLLAA GSQFDTLRRK ENKNVTALEA CALQYYFLIL WRILGILPPS
KNYMNQLAMN TPDMSECDIL HTLRWSSRLR IISYVVWIKD HLIKQGMKAE HAASLIKLAS
TKCSSVKYDV EIAEEYFARQ ISSFCGIDCT TILQLHEIPS LQAIYTLDAA ISKIQVSLDE
HFSKLAAETD PHKSSEITKN LLPATLQLID TYATFTRSYL LRSLSEEGST ENKPSEEKLR
GYAAVLAIGS SRCKSNTLGP TLVQNLPPAV QTLCESWNNI HTNEFPNIGS WRNAFANDTI
PAESYISAVQ AAHLGTLCSQ SLPLAASLKH TLLSLVRLTG DLIVWSDELN PQQVIHTLLP
LLLETSTESV AEISSNSLER VLGPAESDEF LARVYEKLIT GCYNILANHS DPNSGLDESI
LEECLQHLEK QLESSQARKA MEEFFSESGE LVQIMMATAN ENLSAKFCNR VLKFFTKLFQ
LTEKSPNPSL LRLCGSLAQL ACVEPVRLQA WLTRMTMSPP KDSDQLDVVQ ENRQLLQLLT
TYIVRENSQV GEGVCTVLLS TLIPMATEML ANGDGTGFPE LMVVMATLAS AGQGAGHLQL
HSAAVDWLSR CKKYLSQKNV IEKMNANVMQ GKHVTILECT CHIVSYLADV TNALSQTSGQ
GPSHLSVDGE ERAIEVDSDW VEELAVEEED SQAEDSDEDS LCNKLCTFTI TQKEFMNQHW
YHCHTCKMVD GVGVCTVCAK VCHKDHEISY AKYGSFFCDC GAKEDGSCLA LVKRTPSSGM
SSTMKESAFQ SEPRVPESVI RHATTSPAEK SKVTISEGKG PDEEKPKKSS LCRNVEGCRE
ELQSQANFSF APLVLEMLNF LMEAIQINFQ QASAMGSSSR AQQALNELHA VDKTVEMTDQ
LMVPTLGSQE GAFENVRMNY SGDQGQTIRQ LISAHVLRRV AMCVLSSPHG RRQHLAVSHE
KGKITVLQLS ALLKQADSSK RKLTLTRLAS APVPFTVLSL TGNPCKEDYL AVCGLKDCHV
LTFSSSGSVS DHLVLHPQLA TGNFIIKAVW LPGSQTELAI VTADFVKIYD LSVDALSPTF
YFLLPSSKIR DVTFLFNEEG KNIIVIMSSA GYIYTQLMEE ASSAQHGPFY VTNVLEVSHE
DLKDSNGQVA GGGVSVYYSH VLQMLFFSYC QGKSFAATIS RATLEVQRLF PINIKSSNGG
SKTSPALCQW SEVMNHPGLV CCVQQTTGVP LVVMVKPDTF LIQEIKTLPA KAKIQDMVAI
RHTACNEQQR TTMILLCEDG SLRIYMANVE NTSYWLQPSL QPSSVISIMK PVRKRKAAAI
TTRTSSQVNF PIDFFEHNQQ LTDVEFGGND LLQVYNAQQI KHRLNSTGMY VANTKPGGFT
IEVTNNNSTM VMTGMRIQIG TQAIERAPSY LEIFGRTMQL NMTRARWFDF PFTREEALQA
DKKLTIFIGA SVDPAGVTMM DSIKIYGKTK EQFGWPDEPP EDFPSASVSN VCPPNLNQGN
GTGDTEAATP ATASGTVLER LVVSSLEALE SCFAVGPVNE KEKNKAAAQE LATMLLSMPA
PSSVQQQTKS LLASLHTSRS AYHNHKDQAL LSKAIQYLSS SSKEGKDLDP EVFQRLVITA
RSIAIMRPNN LVHFTESKLP QLEAEAGLTH VEATVNALVD IIHGYCTCEL DCINTASKIY
MQMLLCPDPA VSFSCKQALI RVLRPRNKRR HVTLPSSPRS NTPMEQEWNL DSSPGSPTRR
NGYVCEWYLC GPGDKDDDDD DDAEDKMQTS GIANGEHIRQ ESQEQSEVDH GDFEMVSESM
VLETSENVNN GNPSPLEALL AGAEGFPPML DIPPDADDET MVELAIALSL QQDQQGSSSS
ALGLQSLGLS GQAPSSSSLD AGTLSDTTAS APASDDEGST AATDGSTLRT SPADHGGSVG
SESGGSAVDS VAGEHSVSGR SSAYGDTTAE GHPAGPGSVS SSTGAISTTT GQQEGDGSEG
EGEGEAEGDV HTSNRLHMVR LMLLERLLQN LPQLRNVGGV RAIPYMQVIL MLTTDLDGDD
EKDKGALDNL LSQLIAELCM DKKDVSKKNE RSPVNEVHLV VMRLLSVFMS RTKSGSKSSI
CESSSLISSA TAAALLSSGA VDYCLHVLKS LLEYWKSQQN DEEPVATSQL LKPHTTSSPP
DMSPFFLRQY VKGHAADVFE AYTQLLTEMV LRLPYQIKKI ADTNSRIPPP IFDHSWFYFL
SEYLMIQQTP FVRRQVRKLL LFICGSKEKY RQLRDLHTLD SHVRGIKKLL EEQGIYLRAS
VVTASSGSAL QYDTLISLME HLKACAEIAT QRTVNWQKFC IKDDSVLYFL LQVSFLVDEG
VSPVLLQLLS CALCGSKVLS VASSSGSSTS STSAPAASGS GQPATQSKSS TKKSKKEEKE
KEREGESSGS QEDQLCTALV NQLNKFADKE TLIQFLRCFL LESNSSSVRW QAHCLALHIY
RNSNKSQQEL LLDLMWSIWP ELPAYGRKAA QFVDLLGYFS LKTQQTEKKL KEYSQKAVEI
LRTQNHILTN HPNSNIYNTL SGLVEFDGYY LESDPCLVCN NPEVPFCYIK LSSIKVDTRY
TTTQQVVKLI GSHTISKVTV KIGDLKRTKM VRTINLYYNN RTVQAIVELK NKPARWHKAK
KVQLTPGQTE VKIDLPLPIV ASNLMIEFAD FYENYQASTE TLQCPRCSAS VPANPGVCGN
CGENVYQCHK CRSINYDEKD PFLCNACGFC KYARFDFMLY AKPCCAVDPI ENEEDRKKAV
TNINTLLDKA DRVYHQLMGH RPQLENLLCK VNEAAPEKPQ DESGSSGGIS STSASVNRYI
LQLAQEYCGD CKNSFEELSK IIQKVFASRK ELLEYDLQQR EAATKSSRTT VQPTFTASQY
RALSVLGCGH TSSTKCYGCA SAVTEHCITL LRALATNSAI RHILVSQGLI RELFDYNLRR
GAATMREEVR QLMCLLTRDN PEATQQMNDL IIGKVSAALK GHWANPDLAS SLQYEMLLLT
DSISKEDSCW ELRLRCALSL FLMAVNIKTP VVVENITLMC LRILQKLIKP PAPTSKKNKD
VPVDTLTTVK PYSNEIHAQA QLWLKRDPKA SYEAWKKCLP ARGIEANGKS PSRTELHQLY
LSEKYIWKWK QFMSRRGKRT CPLDLKLGHN NWLRQVLFTP ATQAARQAAC TIVEALATIP
SRKQQVLDLL TSYLDELSIA GECAAEYLGL YQKLIKPAHW KVYLAARGVL PYIGNLITKE
IARLLALEEA TLSTDLQQGY ALKSLTGLLS SFVEVESIKR HFKSRLVGTV LNGYLCLRKL
VVQRTKLIDE TQDMLLEMLE DMTTGTESET KAFMAVCIET AKRYSLDDYR TPVFIFERLC
SIIYPEENEV TEFFVTLEKD PQQEDFLQGR MPGNPYSSNE PGIGPLMRDI KNKICQDCDL
VALLEDDSGM ELLVNNKIIS LDLPVAEVYK KVWCPTNEGE PMRIIYRMRG LLGDATEEFI
ESLDSTTDEE EDEEEVYKMA GVMAQCGGLD CMLNRLTGIK DFKQGRHLLT VLLKLFSYCV
KVKVNRQQLV KPEMNTLNVM LGTLNLALVA EQESKDSGGA AVAEQVLSIM EIILDESNAE
PLSEDKGNLL LTGDKDQLVM LLDQINSTFV RSNLSVLQGL LRIIPYLSFG EMEKMQILVD
RFKPYCNFDK YDEEHSGDDK VFLDCFCKIA AGIKNNSNGH QLKDLILQKG ITQNALDYMK
KHIPSAKNLD ADIWKKFLSR PALPFILRLL RGLATQHPAT QVLIGTDSIT NLHKLEQVSS
DEGIGTLAEN LLEALREHPE VNKKIDAARK ETRAEKKRMA MAMRQKALGT LGMTTNEKGQ
VVTKTALLKQ MEELIEEPGL TCCICREGYK FQPAKVLGIY TFTKRVALEE FENKPRKQQG
YSTVSHFNIV HYDCHLAAVR LARGREEWES AALQNANTKC NGLLPVWGPH VPESAFATCL
ARHNTYLQEC TGQREPTYQL NVHDIKLLFL RFAMEQSFSV DTGGGGRESN IHLIPYIIHT
VLYVLNTTRA TSREEKNLQS FMEHPKEKWV ESAYEVDGPH YYTVLALHIL PPEKWKAMRV
EILKRLLVTS HARAVSPGGA SRLTDKTVKE YSTYRSGLLF WALVDLIYNM FKKVPTSNTE
GGWSYSLAEF IRHNDMPIHE AADKALKTFQ EEFMPVETFS EFLDVAGLLT EISDPDSFLK
DLLNSIP
//