ID A0A151MM63_ALLMI Unreviewed; 575 AA.
AC A0A151MM63;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Citrate transport protein {ECO:0000256|ARBA:ARBA00042640};
GN Name=SLC25A1 {ECO:0000313|EMBL:KYO25480.1};
GN ORFNames=Y1Q_0000142 {ECO:0000313|EMBL:KYO25480.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO25480.1};
RN [1] {ECO:0000313|EMBL:KYO25480.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO25480.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in);
CC Xref=Rhea:RHEA:72483, ChEBI:CHEBI:15589, ChEBI:CHEBI:16947;
CC Evidence={ECO:0000256|ARBA:ARBA00036668};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cis-aconitate(in) + citrate(out) = cis-aconitate(out) +
CC citrate(in); Xref=Rhea:RHEA:72475, ChEBI:CHEBI:16383,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036042};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-
CC isocitrate(out); Xref=Rhea:RHEA:72471, ChEBI:CHEBI:15562,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036585};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + maleate(in) = citrate(in) + maleate(out);
CC Xref=Rhea:RHEA:72491, ChEBI:CHEBI:16947, ChEBI:CHEBI:30780;
CC Evidence={ECO:0000256|ARBA:ARBA00036819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + phosphoenolpyruvate(in) = citrate(in) +
CC phosphoenolpyruvate(out); Xref=Rhea:RHEA:72487, ChEBI:CHEBI:16947,
CC ChEBI:CHEBI:58702; Evidence={ECO:0000256|ARBA:ARBA00036159};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + succinate(in) = citrate(in) + succinate(out);
CC Xref=Rhea:RHEA:28835, ChEBI:CHEBI:16947, ChEBI:CHEBI:30031;
CC Evidence={ECO:0000256|ARBA:ARBA00036264};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + trans-aconitate(in) = citrate(in) + trans-
CC aconitate(out); Xref=Rhea:RHEA:72479, ChEBI:CHEBI:15708,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00035792};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO25480.1}.
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DR EMBL; AKHW03005770; KYO25480.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MM63; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR InterPro; IPR049563; TXTP-like.
DR PANTHER; PTHR45788; SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR45788:SF4; TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR Pfam; PF19028; TSP1_spondin; 1.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50920; SOLCAR; 3.
DR PROSITE; PS50092; TSP1; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 98..186
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 197..283
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 293..378
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT DOMAIN 400..449
FT /note="Spondin-like TSP1"
FT /evidence="ECO:0000259|Pfam:PF19028"
SQ SEQUENCE 575 AA; 63635 MW; B8BAFB9C0E27A9BB CRC64;
MGCQSTRVIC KGFWEEGCLS QEKLCLILPC FRMQISCLQP SSGKCFSLGS RRLIASVILP
EHTDPSSLYI KSDSNQILLR ECSTRLRTLV IPASDLVTHP GKAILAGGIA GGIEICITFP
TEYVKTQLQL DEKAHPPRYA GIADCVKQTV RGHGVKGLYR GLSSLVYGSI PKAAVRFGMF
EFLSNQMRDE QGKLDSTRSL FCGLGAGVAE AVMVVCPMET IKVKFIHDQC SPKPKYRGFF
HGVREIVREQ GLKGTYQGLT ATVLKQGSNQ AIRFFVMTSL KNWYKGDDPN KVINPFITGV
FGATAGAASV FGNTPLDVVK TRMQGLEAHK YKSTWDCAYK IMKYEGPLAF YKGTIPRLGR
VCLDVAIVFV IYDEVVKLLN KTGDCCEDYQ AVCQRSAVDC MVGPWGPWSK CSSLCGVGSK
DRTRQVTVPP RNGGTPCPDL KQRRGCFGDS PVCDTAKEVA KILPDSYKRD FKDPWRRPHM
LMKEKQPSYC VYFRLKQVGA ACRLHFWSSH LLRERRVCVE CQGDAVGSRS RCEGDGLQGA
RTFWTAASIA GCQGSWVQES LQETCMCPPL SLLFV
//
