ID A0A151MNY5_ALLMI Unreviewed; 424 AA.
AC A0A151MNY5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Serine protease hepsin {ECO:0000313|EMBL:KYO26246.1};
GN Name=HPN {ECO:0000313|EMBL:KYO26246.1};
GN ORFNames=Y1Q_0013080 {ECO:0000313|EMBL:KYO26246.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO26246.1};
RN [1] {ECO:0000313|EMBL:KYO26246.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO26246.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO26246.1}.
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DR EMBL; AKHW03005634; KYO26246.1; -; Genomic_DNA.
DR RefSeq; XP_014452395.1; XM_014596909.2.
DR AlphaFoldDB; A0A151MNY5; -.
DR STRING; 8496.A0A151MNY5; -.
DR GeneID; 102570449; -.
DR KEGG; amj:102570449; -.
DR CTD; 3249; -.
DR eggNOG; KOG3627; Eukaryota.
DR OrthoDB; 4629979at2759; -.
DR PhylomeDB; A0A151MNY5; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0070008; F:serine-type exopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR015352; Hepsin-SRCR_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF09272; Hepsin-SRCR; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:KYO26246.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..412
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 424 AA; 45406 MW; 1DCA4FBF5CDCACCD CRC64;
MINCSPEMAG KDGAPKVQCW TLPRVVAAVA GGFLLLAGIG ASVWAIVTWV LTGDSEALYG
VQVSPADLRL TVFDEAEGRW RLVCSSPANA LVAALSCEEM GFVRSLWHSE LDVERAGANG
TSGFFCVDEA RLPLASGLAE VVTACECPSG RFVATLCQEC GRRKLPVERI VGGQDAGRGR
WPWQVSLRHD GAHLCGGSLL ASDWVLTAAH CFPERHRVLS RWRVLLGAVS QAAGQGQQVG
VLGVVYHGGY QPFLDPNSEE NADDIALVRL AVPVTFTEYV QPVCLPVRGQ HLVDGKICTV
TGWGNTQYYG QQADVLQEAA VPIISSSVCN TPEYYGNQIR PRMFCAGFAE GGVDACQGDS
GGPFVCEDGV ARARRWRLAG VVSWGTGCAL PRKPGVYTRV GAFHAWIHKA MKTHSQVSGI
VSQH
//