ID A0A151MPQ8_ALLMI Unreviewed; 1256 AA.
AC A0A151MPQ8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN Name=TNKS {ECO:0000313|EMBL:KYO26525.1};
GN ORFNames=Y1Q_0002153 {ECO:0000313|EMBL:KYO26525.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO26525.1};
RN [1] {ECO:0000313|EMBL:KYO26525.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO26525.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO26525.1}.
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DR EMBL; AKHW03005470; KYO26525.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MPQ8; -.
DR STRING; 8496.A0A151MPQ8; -.
DR eggNOG; KOG4177; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd09524; SAM_tankyrase1_2; 1.
DR CDD; cd01438; tankyrase_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 6.20.320.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 18.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 15.
DR PROSITE; PS50088; ANK_REPEAT; 15.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|RuleBase:RU362114}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1256
FT /note="Poly [ADP-ribose] polymerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585368"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 177..209
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 210..242
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 297..329
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 330..362
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 363..395
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 450..485
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 486..518
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 519..551
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 612..644
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 645..677
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 678..710
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 765..797
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 798..830
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 831..863
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 959..1018
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1041..1246
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT REGION 39..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..67
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 135710 MW; 6B6A70AF43E73738 CRC64;
MWQPLPTDTL LAIVVLKLLM PASLHNIGHL FSVGKVATKE AVPERPPRPD SPDRTTAAGP
PLPPPAASSS SSSSSGSSSS ASSSSSSAAS SPAADSPEQP AGPGPGAGSG AFRELLEACR
NGDVTRVKRL VDAGNVNAKD MAGRKSTPLH FAAGFGRKDV VEHLLQTGAN VHARDDGGLI
PLHNACSFGH AEVVSLLLCQ GADPNARDNW NYTPLHEAAI KGKIDVCIVL LQHGADPNIR
NTDGKSALDL ADPSAKAVLT GEYKKDELLE AARSGNEEKL MALLTPLNVN CHASDGRKST
PLHLAAGYNR VRIVQLLLQH GADVHAKDKG GLVPLHNACS YGHYEVTELL LKHGACVNAM
DLWQFTPLHE AASKNRVEVC SLLLSHGADP TLVNCHGKSA VDMAPTPELR ERLTYEFKGH
SLLQAAREAD LAKVKKTLAL EIINFKQPQS HETALHCAVA SLHPKRKQVT ELLLRKGANV
NEKNKDFMTP LHVAAERAHN DVMEVLHKHG AKMNALDTLG QTALHRAALA GHLQTCRLLL
NYGSDPSIIS LQGFTAAQMG NEAVQQILSE STPVRTSDVD YRLLEASKAG DLETVKQLCS
PQNVNCRDLE GRHSTPLHFA AGYNRVSVVE YLLHHGADVH AKDKGGLVPL HNACSYGHYE
VAELLVRHGA SVNVADLWKF TPLHEAAAKG KYEICKLLLK HGADPTKKNR DGNTPLDLVK
EGDTDIQDLL RGDAALLDAA KKGCLARVQK LCTPENINCR DTQGRNSTPL HLAAGYNNLE
VAEYLLEHGA DVNAQDKGGL IPLHNAASYG HVDIAALLIK YNTCVNATDK WAFTPLHEAA
QKGRTQLCAL LLAHGADPTM KNQEGQTPLD LATADDIRAL LIDAMPPEAL PTCFKPQATV
VSASLISPAS TPSCLSAASS IDNLTGPLAE LTVGAASNAG DGAAGTERKE GEVTGLDMNI
TQFLKSLGLE HLRDIFETEQ ITLDVLADMG HEELKEIGIN AYGHRHKLIK GVERLLGGQQ
GTNPYLTFHC VSQGTILLDL APDDKEYQSV EEEMQSTIRE HRDGGNAGGI FNRYNVIRIQ
KVVNKKLRER FCHRQKEVSE ENHNHHNERM LFHGSPFINA IIHKGFDERH AYIGGMFGAG
IYFAENSSKS NQYVYGIGGG TGCPTHKDRS CYICHRQMLF CRVTLGKSFL QFSTMKMAHA
PPGHHSVIGR PSVNGLAYAE YVIYRGEQAY PEYLITYQIV KPEAPSQTTT AAEQKT
//
