ID A0A151MPT0_ALLMI Unreviewed; 1034 AA.
AC A0A151MPT0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Breast cancer type 2 susceptibility protein isoform C {ECO:0000313|EMBL:KYO26400.1};
GN Name=BRCA2 {ECO:0000313|EMBL:KYO26400.1};
GN ORFNames=Y1Q_0010377 {ECO:0000313|EMBL:KYO26400.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO26400.1};
RN [1] {ECO:0000313|EMBL:KYO26400.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO26400.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO26400.1}.
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DR EMBL; AKHW03005510; KYO26400.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MPT0; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR CDD; cd04495; BRCA2DBD_OB3; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 3.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 429..470
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 34..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 443..470
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 973..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 116999 MW; 7F4CD2DE8152A8A5 CRC64;
MDKNFPLNMR IGKRCMAEQI SVEEPPIKRQ LLPEFDRTKD PHKSLNASKS TPDGTIKDRR
KFIYHVPLKP VTCSPFSATK LDDLADEKLG NKTLDSLTNS NMNVDKKQKD ALVQQNTGQG
EAYQSDERDC TNHAAARNLG NNGADLTNMI TNLHQARNLQ EMRIGKKYRQ NIQPQPGSLY
IMKTSAVKRI SLKAAVENNS LHIYSTEELY MYGVSKSCIQ VNSINAESFE FLIQDFFSEE
YFLAGHGVQL GDGGWLIPTE EGRAGKNEFY RALCDTPGVD PKLITDAWVY NHYRWIVWKL
AAMEVSFPQE FASRCLTPER VLLQLKYRYD LEVDKMLLQR RRLTIGQKII VHGAELVGSQ
NACTPLEAPD TLMLKISANG TRRARWYAKL GFHRDPRPFP LSLSSLFSDG GTVGCIDIVI
QRAYPLQWME KKPTGSYVFR NNRAEEREAA KHAENQQKHL EALFAKIQAE YEQNEGKTRK
RVLRSCALTK QQIQTLQDGA ELYEAIQNSP DPGYMEGYLS EEQLRALNTH RQMLNDKKQA
QIQAEFKKAL ESIEQEERGY SVREVSTVWK LRVVDYRKQE KVKVVMLNIW RPLSDVFSLL
KEGNRYRIYQ LATSESKSKL DTANVQLTAT KKTQFLQLSA SQEMLLEIYI PRNAVLFSKL
LDLSFQPACG EVDLVGFIVS VNKSTGFTTL VYLSDENLNL VAIKIWMDLK QLAVEDIIKP
CTLISASNIQ WQSANFRLEI PTLFAGDLSL FSTNPKEGYL QERFNELKNT IENVNSFCSD
AKCKLMNLLQ TNGPQVNNLN KECGLSLLSP SQKSSLCVGN KNHTSFPNSE MKYQSPLSVS
KPDMKLAPQG LAKMIPHTPN EDYPKNCKKR KAMDLLSQIP PPPPLTPVYS IVSPSLKKAF
QPPRSSDFQC SKSSKGTNHD TVHITALKRL NEITPLAETD LIADEELAMI NTQALLCNLP
KEKKTDYTEK TISAASRDSS DHLVHGNSPM SAAGTNTSQN STEGTEALEK ETSKTESSFT
VPKKLQRRKK RKYY
//
