ID A0A151MQG9_ALLMI Unreviewed; 1209 AA.
AC A0A151MQG9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ATP-binding cassette sub-family B member 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0019242 {ECO:0000313|EMBL:KYO26787.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO26787.1};
RN [1] {ECO:0000313|EMBL:KYO26787.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO26787.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO26787.1}.
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DR EMBL; AKHW03005461; KYO26787.1; -; Genomic_DNA.
DR RefSeq; XP_019353643.1; XM_019498098.1.
DR AlphaFoldDB; A0A151MQG9; -.
DR GeneID; 102567326; -.
DR CTD; 340273; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR43394:SF11; ALPHA-FACTOR-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR43394; ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 3.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..360
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 396..564
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 640..932
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 967..1205
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 16..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1209 AA; 133094 MW; 65C0E5F7D7DE6DD1 CRC64;
MMEDIDIKIV GDTEQNSANN VDLDDQPPKE NEKKNKNPQT IGPITIFRYA DRLDITLMIL
GAVAAVINGT CLPLLSLVFG EMSDSFVINC QSRENVSSSS HCNQTQMPSE EQITVFALYY
VGIGVAALLF GYLQISFWVL AATRQTKKIR RMFFHAVLRQ EISWFDITTS GELNTRLIED
INKINDGIGD KIAQLIQNMT TFIVGIVIGF VIGWKLTLVI LSTSPLVVLS AAFCSKMIIT
LTSKELTAYS KAGAIAEEVL SSVRTVVAFG GQEKEIKRYT SRLGEAKNIG IKKAIASKLS
LGFVYLIING CYGLAFWYGT TLILEDNSEY TIGSVLAIFF CVTYSSYCIG IASPHFETFA
IARGAAFKIF KIIDENPSID SFSSDGHKLS HIKGTLEFDN VRFSYPSRPD IQILKGLNLK
IGAGQTVALV GSSGCGKSTT VQLLQRFYDP QGGVKFNTLV GERGAQMSGG QKQRIAIARA
LVRNPKILLL DEATSALDTE SEAVVQAALE KASRGRTTIV IAHRLSTIQT ADVIMTIVDG
TVAERGTHAE LMEKKGLYYS LATAQSIKKA EYSEESAETV PIKNREETPP SNSLISEKAS
IKHIPQKVSE EEVKPEEEHL PQVSLLKLFR LNKSEWPLIA IGTLAAIING ACSPVFAVIF
GKIVTIFEIK NVSTSYKEQI QHEANILSII FAGIGVVSFL TYFFQGFLYG RSGEILTMRL
RHMAFKAMLR QDISWFDDKK NSTGALTTRL ATEAAQVQMA VGSRLGVIAQ NISTMGLSII
ISFIYGWEMT LLILVIAPVL TVTGMLEVSA LTGFANRDKK EMQRAGKVAI EAVENIRTVA
SLTRERAFEK MYEENMQKPY RNAQKKAQIY GSCYAFSQAF LYFTYAAGFR FGAYLITAGR
MTPEGVFVVF TAIAYGAVAV GETLTFVPDY AKAKSGAAHL FALFERTPAI DSYSEEGDKP
DTFSGRLEFH EVTFIYPTRP DVPILQDLSL TIERGQTVAF VGSSGCGKST SVQLLQRFYD
PLKGQVLFDS TDVKHLNVQW LRSQIGIVSQ EPVLFDCSIA ENIAYGDNNR TVPMDEIIAA
AKAANIHTFI EELPKKYNTR VGDKGTQLSG GQKQRIAIAR ALIRQPKMLL LDEATSALDN
ESEKVVQQAL DQARKGRTCI VIAHRLSTIQ NADIIVVINN GKIIESGTHH QLMAKQKAYF
NLVNAQTLL
//
