ID   A0A151MQK0_ALLMI        Unreviewed;       851 AA.
AC   A0A151MQK0;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   ORFNames=Y1Q_0019263 {ECO:0000313|EMBL:KYO26817.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO26817.1};
RN   [1] {ECO:0000313|EMBL:KYO26817.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO26817.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO26817.1}.
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DR   EMBL; AKHW03005461; KYO26817.1; -; Genomic_DNA.
DR   RefSeq; XP_014458678.1; XM_014603192.2.
DR   AlphaFoldDB; A0A151MQK0; -.
DR   STRING; 8496.A0A151MQK0; -.
DR   CTD; 26031; -.
DR   eggNOG; KOG1737; Eukaryota.
DR   OrthoDB; 960at2759; -.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          50..145
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  97400 MW;  B552B6A9B0EA9A93 CRC64;
     MSEEKNLGVS QKMLSPSRST SSCSSKHGSR QDSWEIIEGL RGVVNCTLEP QKQEGYLLKK
     RKWPLKGWHK RYFFLAGGIL KYSKCQADIE RGKLHGCIDV GLSVMSVKKS TKCIDLDTEE
     HIYHLKVKSQ EVFEEWVAKL RHHRMYRQNE ISMFPLDVNN HFFPTSTTDS VPSAFDSTSS
     RKARSITKQN SVQTGSSLSF SCTSSESRIP SWLQSSEDME KCSRDLSHCH TYLLEMNQLL
     QSMEVLHRTY SAPAINVIQG GSFESPKKEK RTHRRWRSRA INKDAKGMLQ VPSVFSAPLR
     LHASNPNLST IDFVEEKNYS DGLETSAEFS KMQEDLCHVA HKVYFTLRSA FSTLSTEREK
     LKQMLEQDAS SSPSAQIAGL KNALSSENSG EESRGLVHQV SNESRLSITD SLTEFFDAQE
     VLLSASSSEN EVSDDDSYVS DISDNISEDN LSNDIENERQ TLVAVGEIRI ECHSERRTCL
     PAPCPNTSNI SLWNILRNNI GKDLSKVAMP VELNEPLNTL QRLCEELEYS ELLDKAAHTP
     DPFERMVYVA AFAVSAYASS YYRAGSKPFN PVLGETYECI REDKGFQYFS EQVSHHPPIS
     ACHAESANFA FWQDMRWKNK FWGKSMEIVP VGTTHATLPA FRDHFVWNKV TSCIHNILSG
     QRWIEHYGEI IIKNLNDDTC HCKLTFMKAK YWSPNVHEIE GSVINKNGKV VHRFFGKWHE
     SLYYGTSSSP SCIWRANPMP KDYEQWYGFT QFALELNELD PQTRPLLPAT DTRFRPDQRL
     LEEGNTEGAE MQKQRIEQLQ RERRKVLEEN NLEHHPRFFR KSIDDSWVSN GTYLDLRKDP
     GFSKLDSPVL W
//