ID A0A151MSB9_ALLMI Unreviewed; 2146 AA.
AC A0A151MSB9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=Y1Q_0021242 {ECO:0000313|EMBL:KYO27319.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO27319.1};
RN [1] {ECO:0000313|EMBL:KYO27319.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO27319.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO27319.1}.
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DR EMBL; AKHW03005226; KYO27319.1; -; Genomic_DNA.
DR STRING; 8496.A0A151MSB9; -.
DR eggNOG; KOG0384; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18668; CD1_tandem_CHD5-9_like; 1.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.40.5.120; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR PANTHER; PTHR46850:SF1; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR Pfam; PF07533; BRK; 2.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 2.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 232..295
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 315..381
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 414..588
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 728..884
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1571..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1747..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2073..2146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1660..1679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2146 AA; 245260 MW; 302AACB870FE0C00 CRC64;
MHPWHSSVSN QHVQGRNRVT LQGQPPSSKK TDGSGAYTKL QNTQVRAMSE KKQKKKVESE
SKQEKANRII SEAIAKAKER GERNIPRVMS PENFPSVSAE GKEEKKGRKI KSKPKDKESK
KPRTGSSSKI KEKTKIGKLI ITLGKKQKRK NESSDELSDA KQTPQRSFKD EDLQKRRSNR
QVKRKKYAEE GEGKQSEEEA KVSVKIKKNS APLPAEQPLQ LFVENPSEED AAIVDKILSS
RIVKKEVSAG VTVEAEEFFV KYKNYSYLHC EWATEQQLLK DKRIQQKIKR FKLRQAQRAH
FFADMEEEPF NPDYVEVDRV LEVSFCEDKD TGEPVVYYLV KWCSLPYEDS TWELKEDVDQ
AKIEEFEQLQ ASRPDSRRLD RPPPNSWKKI EHSREYKNGN QLREYQLEGL NWLLFNWYNR
RNCILADEMG LGKTIQSITF LYEILLTGIR GPFLIIAPLS TITNWEREFR TWTDINVVVY
HGSMVSRQMI QQYEMYFRDS QGRIIRGTYR FQAIITTFEM ILGGCPELNA IEWRCVIIDE
AHRLKNKNCK LLEGLKLMNL EHKVLLTGTP LQNTVEELFS LLHFLEPLRF PAESTFMQEF
GDLKTEEQVQ KLQAILKPMM LRRLKEDVEK KLAPKEETII EVELTNIQKK YYRAILEKNF
AFLSKGAGQA NVPNLVNTMM ELRKCCNHPY LIKGAEEKIL GEFRETHSPT APDFHLQAMI
HSAGKLVLID KLLPKMKAGG HKVLIFSQMV RCLDILEDYL IHKRYLYERI DGRVRGNLRQ
AAIDRFSKPD SDRFVFLLCT RAGGLGINLT AADTCIIFDS DWNPQNDLQA QARCHRIGQN
KAVKVYRLIT RNSYEREMFD RASLKLGLDK AVLQSMSGRE NSVGGIQQLS KKEIEDLLRR
GAYGAIMDEE DEGSKFCEED IDQILQRRTK TITIESEGRG STFAKASFVA SGNRTDISLD
DPNFWQKWAK KAEIDIEAIS GRNSLVIDTP RIRKQTRPFS ATKDELAELS EPESEGDEKP
KLRRPCDRSS GYGRTECFRV EKNLLVYGWG RWREILSHGR FKRQLNEQDV EIICRALLAY
CLVHYRGDEK IKSFIWDLIT PTEDGQTREL QNHLGLSAPV PRGRKGKKVK TQASTFDIHK
AEWLRKYNPE HLLQDEGYKK HIKHHCNKVL LRVRMLYYLK QEVIGNDFQK VFDGADASEI
DIWVPEPDHS EVPAEWWDAD ADKSLLIGVF KHGYEKYNTI RADPALCFLE RVGKPDEKAV
AAEQRANDYI DGDVEDPEYK PAPAMFKDDM EDDVSSPGDL VIADGDGQMM EGDKIYWPTQ
SALTTRLRRL ITAYQRTNKN RQTQQIQPAF PVQASMMQPS YEEAALNPKM AAKIERQQRW
TRREEADFYR VVSTFGVVFD PDRGRFDWTK FRAMARLHKK TDESLEKYLY AFMSMCRRVC
RLPSKEELVD PGIFIQPITE ERASRTLYRI ELLRKVREQA LRHPQLFERL KLCQPNPDLP
VWWECGTHDR DLLIGAAKHG VSRTDYHILR DPELSFMSAQ RNYSQNKVAL SRTSTPLLHQ
YQMALSASPL ASQARLPDAK GNALEDTKAK NENVKEEPHS SEEESMSTEE IQTGMKSESL
SPKNGTPSQT TNHKPKSDSD EEAQKRAEGT PHMKAYDEES VASLSTTQDE TQDSFQLNNG
TQNSTYLLQG GYMLAASYWP KDRVMINRLD SICQTVLKGK WPSARRSYDN NTVASFYTTK
LLDSPGAAAD YSEPSAPTPP SAGVKEERDQ SPQMSKVKKH VREKEFTVKI NDEGGLKLTF
QKQGLSQKRP FESEEGTLGQ QQYLARLREL QNASETSLVN FPKSLPESGT SSQLTASANG
VIADSQPVVK KRRGRRKNVE GVDILFINRN KQPNHVSPGI NTSQIAPGIN PTFTFAQSQS
LLDEESPVPV INLKDGTRLA GDDAPKRKDL EKWLKEHPGY VEDLGAFIPR MQLHDGRPKQ
KRHRCRNPNK LDVNSLTGEE RVQLINRRNA RKVGGAFAPP LKDLCRFLKE NPEYGVAPEW
GEVVKQSGFL PEGMLLTPGL NLHIPALSQS NIFDVQNSEN NDTGSVKPTE EKEENSRIRD
QEDKGGTEPS SHNENSTDEG SEKADASSGS DSTSSSSEDS DSSDED
//
