ID A0A151MUX5_ALLMI Unreviewed; 694 AA.
AC A0A151MUX5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase E-like {ECO:0000313|EMBL:KYO28284.1};
GN ORFNames=Y1Q_0021982 {ECO:0000313|EMBL:KYO28284.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28284.1};
RN [1] {ECO:0000313|EMBL:KYO28284.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28284.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO28284.1}.
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DR EMBL; AKHW03004933; KYO28284.1; -; Genomic_DNA.
DR RefSeq; XP_014459762.1; XM_014604276.2.
DR AlphaFoldDB; A0A151MUX5; -.
DR STRING; 8496.A0A151MUX5; -.
DR GeneID; 102566555; -.
DR KEGG; amj:102566555; -.
DR eggNOG; ENOG502QUPB; Eukaryota.
DR OrthoDB; 5344745at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF36; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000313|EMBL:KYO28284.1}.
FT DOMAIN 267..359
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 333
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 356
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 396
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 398
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 446
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 451
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 694 AA; 76915 MW; 936D6A4783AE538D CRC64;
MGQALTLREV NWQRSENGSA HHTDKYPGKE LVVRRGQAFT ITLTFSGEWK TGQGLTFIAE
TGPRPSLQAK TQAVFDISKP ASKDTWGAVV QSTSSGSARI SISSPATAPI GRYRLSVRVT
LAGRSSTLNI GTFVLLFNPW SKEDVVFMPN AAECNEYVLE EFGVLFVGSS FYMHSFGWNY
GQFQAGILDI CLSILDRSLE YRRDAAADVS RRNDPKYVGR VLSAMVNSPD DNGVLMGNWS
GEYSGGKSPN SWNGSVAILV NWKQSGYKSV RYGQCWVFAA VLATVLRCLG IPSRAISNFN
SAHDVDENLT VDEYYDAAGN PLNTGEDSVW NFHVWNEGWF TRSDLGSSYD GWQVLDATPQ
ERSEGIYRCG PASVTAVKEG DVDLKHDVPF VFAEVNADRV AWTYDSATRN KKPLHTDTRS
IGQSISTKAV GSYARVDVTN TYKYEEGSQK EREIFEKAHK KMVPDAELRG TSARLLEIIP
KPYISGKFKV DSPLEVGKDV NLILILSNLT SVARNVKANI TAWAIVYTRK PIREIWKDTL
SVTLAANEEK QLPIKITYAE YQQRLTTDNM IQITALCQVQ SGTEVLVQRE LTMTNPPVDM
KVLGEAKVNK AVEVEVMFTN PINEEVKDCV LRAEGNDLLN GSLKINVPSL KPNETSAVQF
EIIPTKSGTK QLLINFSCDK FSDIKAFETI NVAK
//
