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Database: UniProt
Entry: A0A151MUX9_ALLMI
LinkDB: A0A151MUX9_ALLMI
Original site: A0A151MUX9_ALLMI 
ID   A0A151MUX9_ALLMI        Unreviewed;      4521 AA.
AC   A0A151MUX9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   28-FEB-2018, entry version 11.
DE   SubName: Full=Ryanodine receptor 3 isoform C {ECO:0000313|EMBL:KYO28312.1};
GN   Name=RYR3 {ECO:0000313|EMBL:KYO28312.1};
GN   ORFNames=Y1Q_0015927 {ECO:0000313|EMBL:KYO28312.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28312.1};
RN   [1] {ECO:0000313|EMBL:KYO28312.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28312.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO28312.1}.
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DR   EMBL; AKHW03004924; KYO28312.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KYO28312.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3851   3873       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4063   4083       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4130   4149       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4322   4343       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4402   4425       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       84    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      146    191       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    253       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      259    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      327    384       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      569    780       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1192       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1451       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      443    463       {ECO:0000256|SAM:Coils}.
FT   COILED     3160   3180       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4521 AA;  512707 MW;  C7BAF4445C729661 CRC64;
     MDDEVVLQCV ANIHKEQRKF CLAAEGLGNR LCFLEPTSEA KYVPPDLCIC NFVLEQSLSV
     RALQEMLANT GDNASEGAAQ GGGHRTLLYG HAILLRHSFS GMYLTCLTTS RSQTDKLAFD
     VGLRENAAGE ACWWTIHPAS KQRSEGEKVR IGDDLILVSV SSERYLHLSM SNGNIQVDAS
     FMQTLWNVHP TCSGSSITEG FLLGGHVVRF FHGHDECLTI PSMDQNDLQQ KRVLYETGGA
     GVRARSLWRV EPLRISWSGS NIRWGQPFRL RHITTGEYLA LSEEEGLVML DREKSDTTST
     AFCFRASKEL KEKQDSSHKR DIDGMGVPEI KYGDSICFVQ HVASALWLTY KAQDAKTARL
     GPLKRKVILH QEGHMDDGLT LQRCQHEESQ AARIIRNTTS LFNQFISGNN RISAPIALPI
     EEMLQTLQDL ITYFQPPEEE LEHEDKQNKL RSLKNRQNLF KEEGMLALVL NCIDRLNDYN
     SAAHLVGVAR EVNGTAWKEI LNHLYKLLAA LIRGNRNNCT QFSGNLDWLI SKLDRLESSS
     GILEVLHCIL TESPEALNLI AEGHIKSIIS LLDKHGRNYK VLDVLCSLCL CNGVAVRANQ
     NLICDNLLPR RDLLLQTRLV NDVTSIRPNI FLGVAEGSAQ YKKWYFELII DQVDPFLTAE
     PTHLRVGWAS TSGYAPYPGG GEGWGGNGVG DDLFSYGFDG LHLWSGRVSR PVASVNQHLL
     ASDDVVSCCL DLGVPSISFR INGQPVQGMF ENFGTDGLFF PVVSFSAGVK VRFLLGGRHG
     EFKFLPPAGY APCYEALLPK EKMKLEPVKE YKRDFDGVRD LLGTTQFLSQ ASFIPCPIDT
     SQIVLPLHLE KIRDKLAENI HELWGMNKIE LGWTYGKVRD DNKRQHPCLV EFSKLPETEK
     NYNLQMSTET LKTLLALGCH IVHSNLAAEE DLKKVKLPKN YMMSNGYKPA PLDLSEVKLL
     PSQEVLVDKL AENAHNVWAK DRIKQGWTYG IQQDLKNKRN PRLVPYALLD ERTKKSNRDS
     LREAIRTFAG YGYNIEPPDQ EIADQAMQKV SIDKIRFFRV EQSYAVKTGK WYFEFEAVTG
     GDMRVGWARP GCRPDLELGA DDQAFVFEGS KGQRWHQGSG FFGRNWQPGD VVGCMINLDD
     KSMIFTLNGE LLITNKGSEL AFADFQLENG FVPICSLGLS QIGRMNLGMD ASTFKYYTMC
     GLQEGFEPFA VNMNRDVAMW FSKRLPTFVN VPKNHPHIEI TRIDGTIENP PRLKVTHRTF
     GTQNSNADMI YCRLSMPIEF HSSFNYNTGA ESASADAFQK RKQSQEIAVP STYYYSVRIF
     AGQDPSSVWV GWVTPDYHYY SENFDLNKNC TVTVTLGDER GRVHESVKRS NCYMVWGGDV
     TAHSQRSGRS NVDLEIGCLV DLATGMLSFT ANGKELGTCY QVEPNTKLFP AAFVQPTSTN
     LVQFELCKLK NTMPLSAAIF KSEEKNPVPQ CPPRLDVQTI TPVLWSRMPN SFLKVETERV
     SERHGWVVQC LEPLQMMALH IPEETRCVDI LELCEQEDLM MFHYHTLKLY CSVCALGNSR
     VAYALCSHVD ISQLFYTIDN QYLPGLLRSG FYDLLISIHL EHAKQAKLMM NNEFIIPITD
     ETRTIELYPD ETKKHGLPGV GLSTCLKPGY YFSTPCFIVT SDEHLKSSPE ISLDILKSKA
     ISMLTEAVHC SGTHIRDPVG GQVEFQFVPV LKLIGTLLIM GVFDDDDVKQ ILLLIDPNVF
     GEHKEETEEK TEKEEVTQIE EKAVEAGEKA IKETKAPIKG LLQTRLPESV KLQMCLLLNY
     FCDCELQHRV ESIVSFADNY VSKLQYNQRF RYNELMQALN MSAALTAKKT KEFRSPAQEQ
     INMLLNFQLG EDCPCPEEIR DELYEFHDDL LIHCATLKQL ISQTMVRWAQ EDQMQDSELV
     RIMYTLLRRQ YDSIGELLQA LRKAYTISAA SVQDTINLLA ALGQIRSLLS VRMGKEEELL
     MINGLGDIMN NKVFYQHPNL MRVLGMHETV MDVMVNVLGG DKSQRIIFPK MVASCCRFLC
     YFCRISRQNQ KAMFEHLSYL LENSSVGLAF PSMRGSTPLD VAAASVMDNN ELALALEEPD
     LEKVVTYLAG CGLQSCPVLL AKGYPDIGWN PIEGERYLTF LRFAVFVNSE SVEENASVVV
     KLLIRRPECF GPDLRGEGGN GLLAAMQEAI NISENPARDL PSQGYKREGA AEDEEEEEIV
     HMGNAIMSFY SALIDLLGRC APEMHLIQSG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL
     STVNKDGTVN EPDMSASFCP DHKAPMVLFL DRVYGIKDQS FLLHLLEVGF LPDLRASASL
     DTVSLSTTEA ALALNRYICS AVFPLLKRCA PLFSGTEHYA SLIDSTLHTI YRLSKGRSLT
     KAQRDTIEEC LLAVCHHLRP SMLQQLLRRL VFDVPLLNEY CKMPLKLLTN HYEQCWKYYC
     LPSGMGSYGI AAEEELHLTE KLFWGIFDSL SHKKYDPELF RMALPCLSAI AGALPPDYLD
     TRIRATLEKQ TSLDPEGNFD PKPINTVNLA LPEKLEYIVS KYAEHSHDKW AFDKTNSGWK
     YGVSLDENMK THPLIRPFKT LTEKEKEIYR WPARESLKTM LAMGWRLERT KEGEAMVQQR
     ENEKLRSISQ SSQGNGYSPA PLDLSNVVLS RELQGMVEVM AENYHNIWAK KKKMELESKG
     GGSHPLLVPY DTLTAKEKSR DREKAQELFK FLQVNGIVIS RGLNDMELDA SSMEKRFAFK
     FLKKILKYVD SAQEFIAHLE AIVTSGKTEK SPHDQEIKFF AKVLLPLVDQ YFTNHCLYFL
     SSPIKSLSSS GYASNKEKEM VASLFCKLAA LVRHRISLFG SDATTVVSCL HILAQSLDTR
     TVMKSGSELV KAGLRAFFEN AAEDLEKTSE NLKLGKFTHS RTQIKGVSQN INYTTVALLP
     ILTSMFEHIA QHHFGVDLLL GDVQVSCYRI LCSLYSLGTG KNIYVERQCP ALGECLASLA
     AAIPVAFLEP SLNRYNPLSV FNTKTARERA ILGMPDTVEE MCPEIPHLDG LMREINGLAE
     SGARYTEMPH VIEVILPMLC NYLSYWWEKG PESMPISAGP CCTMITSEHL SIILGNILKI
     INNNLGIDEA SWMKRIAVYA QPIISKARPD LLKTHFIPTL EKLKKKAIKI VIEEEQLRAD
     SKTDTQEAEL LILDEFAVLC RDLYAFYPML IRYVDNNRAN WLKKPDADSV ELFRMVAEVF
     ILWCKSHNFK REEQNFVIQN EINNLAFLTG DSKSKMSKSG GQDQERKKSK RRGDLYSIQT
     SLIVAALKKM LPIGLNMCTP GDQELISLAK IRYSHRDTDE EVKEHLLNNL HLQEKSEDPA
     VKWQLNLYKD IMKSDEPPDP EKTVERVQRI SAALFHLEQV EQPLRSKKAV WHKLLSKQRK
     RAVVACFRMA PLYNLPRHRS INLFLHGYQN YWIETEEYSF EEKLVQDLAT PPRKEEEEEE
     ETEKKHPDPL HQIILYFSHN ALTERSKLED DALYISYSAM MAKEKEMEKQ KTLYQQARLH
     DRGAAEMVLQ MISASKGKMG LMVIETLKLG IAILNGGNTI VQQKMLDYLK EKKDAGFFQS
     LSGLMQSCSV LDLNAFERQN KAEGLGMVTE EGTREKVLQY DEFTRDLFRF LQLLCEGHNN
     DFQNYLRTQM GNTTTVNIII STVDYLLRLQ ESISDFYWYY SGKDVIDDSG QRNFSKALAV
     TKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD AVVGFLHVFA NMQMKLSQDS SQIELLKELL
     DLLQDMVVML LSLLEGNVVN GTIGKQMVDT LVESSSNVEM ILKFFDMFLK LKDLTNSDAF
     KEYDPDGLFQ LFFTIVWGIF QILWSTVFGG GLVEGAKNIK VTKILGDMPD PTQFGIHDDV
     METEKAEGVE HGIRAELVQF VKGEKGETDI MSDIFGIRTK KEGGSKYSHD AGLGDIKEII
     GSDSPSSLEN AVRKKKRAQT SEIAKEVEME IKTESEKADM EDGEKQDKAK EIQSEHLEEG
     KMKKKKRRRG QKIEKPEAVM ANFVKALEVY QTKMLHCLAR NFYNLRFLAL FVAFAINFIL
     LFYKVTEEPL DEVEEDSNLW NSFDEDEEEE GMVFFVLEES TGYMAPTLRG LAIIHTVISF
     VCVIGYYCLK VPLVVFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTPSFPNNY
     WDKFVKRKVI NKYGDLYGAD RIAELLGLDK NALDFSPVEE TEPDEASLVS WLSSIDTKYH
     IWKLGVVFTD NSFLYLAWYT TMSILGHYNN FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ
     LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDEDEPDMKC DDMMTCYLFH MYVGVRAGGG
     IGDEIEDPAG DPYEMYRIVF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVREDMET
     KCFICGIGND YFDTTPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ ESFVWKMYQE
     RCWDFFPAGD CFRKQYEDQL G
//
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