ID A0A151MX27_ALLMI Unreviewed; 1091 AA.
AC A0A151MX27;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Leptin receptor {ECO:0000256|ARBA:ARBA00019169};
DE AltName: Full=OB receptor {ECO:0000256|ARBA:ARBA00031601};
GN Name=LIFR {ECO:0000313|EMBL:KYO29025.1};
GN ORFNames=Y1Q_0009837 {ECO:0000313|EMBL:KYO29025.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29025.1};
RN [1] {ECO:0000313|EMBL:KYO29025.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29025.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO29025.1}.
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DR EMBL; AKHW03004724; KYO29025.1; -; Genomic_DNA.
DR RefSeq; XP_014449609.2; XM_014594123.2.
DR RefSeq; XP_019351509.1; XM_019495964.1.
DR RefSeq; XP_019351510.1; XM_019495965.1.
DR AlphaFoldDB; A0A151MX27; -.
DR STRING; 8496.A0A151MX27; -.
DR GeneID; 102570614; -.
DR KEGG; amj:102570614; -.
DR CTD; 3977; -.
DR eggNOG; ENOG502QQF6; Eukaryota.
DR OrthoDB; 5347052at2759; -.
DR PhylomeDB; A0A151MX27; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR InterPro; IPR040901; LIFR_N.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF105; LEUKEMIA INHIBITORY FACTOR RECEPTOR; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR Pfam; PF18207; LIFR_N; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:KYO29025.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1091
FT /note="Leptin receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585543"
FT TRANSMEM 823..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 325..422
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 423..522
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 524..618
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 715..821
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 909..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 121737 MW; 4AED46C0662702EE CRC64;
MWNNPSLRCL LVVACLHLTS LLYSQETGYS EAPQTLRCIT HDFNIMTCSW DAFSSTNLGQ
SYEFCYENSG LLVCNKNKEK SADIPIVHGS TTIKITTLNA SGTPLATTTF ILPEKNVSFI
PVTPQILSLT PDFSTEMLYL KWKDGGSAFP FDLDATWQIE VLRKETLERV AQVTYHSKLT
SKDTIISWNW KSDMPLECVS HSVRIRCYIN KMNYGGNKEW SEWSPVVTVP GEVPDLSFAK
VFPQDKVVPV GSNMTFCCLH NEDERIEHIK YGLKSYPLLH LSEWSSAIQV QNVSASESSG
TNIWCSLLPY GVEGTVLFVG YPPDIPQNLT CETHTLDKII CTWNPGRPTE LFASRQTNYI
LSERISGRNG TCRVTENTMG NVCVFTVLAT QNIYNFTLQA FNPVGQTESS LSIDINQRVH
PKTPSKFTVT GESPTKAHVS WYLPGNFIQI KLLCQIEISK SHSEPELDNV TVYGTVNSCY
EAQLDMLHPN TAYTFRVRCS AADHFWKWSN WSEKKQWTTW EAPPVRGPDI WRERSSVGGN
VVKIFWKPLP LLEANGIIHS HVVSCYLDTA VQSKEIPASL NSTDIELGKN DCNISVVAKN
GAGSSPPSRI TSVELPSDNV KTKQAIATGS GIYITWQSDP DVNCGYTVKW CRSPGCEPYS
VDWETFPSNA TEAVITSALF QPGVRYNFSL YACKSSGYQL LQNITGYIQE LAPKVAPNFT
VEETSSDSIL VKWENIPVED CQGFLKGYLL FFAKGEKDPL KPKLLEPGHP ELKVKNITDL
TKKSLRILDL QGKTSYQLDL RAYTAGGIGP SNGLYVVTKE DSVGLIIAIL IPVAVALVFG
VVTSILCYRK REWIKETFYP DIPNPENSKA LQFQKNICEG NTALKTLEMN PCTPNSVEVL
ETRSAVPKME DTEIKSPVAD SEPPEDVSDT ETENLVVVSY CPPIIEEEIS NPSVDEPVGS
SQVIYIDVQS MYQPQVKPEE EPEIDFVTTE GYKPQMHLSI NTIKTENHLP TEEDSDKTAG
YRPQANTNAW NVGTPDSPRS IESNNENTSF GSPCSINSRQ FLIPPRDDED SSKPNNIGWS
FTNFFQNKPS D
//
