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Database: UniProt
Entry: A0A151MZ08_ALLMI
LinkDB: A0A151MZ08_ALLMI
Original site: A0A151MZ08_ALLMI 
ID   A0A151MZ08_ALLMI        Unreviewed;      2175 AA.
AC   A0A151MZ08;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   28-MAR-2018, entry version 14.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0023159 {ECO:0000313|EMBL:KYO29803.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29803.1};
RN   [1] {ECO:0000313|EMBL:KYO29803.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29803.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO29803.1}.
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DR   EMBL; AKHW03004488; KYO29803.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    151    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    188    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    220    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    292    315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    404    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    449       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    562    580       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    600    623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    692    711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    764    791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    925    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    963    983       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    995   1021       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1041   1071       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1168   1193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1247   1265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1277   1297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1372   1395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1464   1487       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1621   1655       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      794    825       {ECO:0000256|SAM:Coils}.
FT   COILED     1582   1602       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2175 AA;  246645 MW;  2F7115EDD6B115AB CRC64;
     MDMGAKTRAV ASNSPVARRG ARRRARGLTV FSPLVTHRAQ EGNYASSTRI PLPGDGPIIQ
     SNSSAPSKQT VLSWQAAIDA ARQAKAAQTM STTAAQPVGS LSQRKRQQYA KSKKQGNTSN
     SRPPRALFCL SLNNPIRRAC ISIVEWKPFD IFILLAIFAN CVALAVYIPF PEDDSNSTNH
     NLEKVEYAFL IIFTIETFLK IIAYGLLLHP NAYVRNGWNL LDFVIVIVGL FSVILEQLTK
     EAEGGSHSGG KPGGFDVKAL RAFRVLRPLR LVSGVPSLQV VLNSIIKAMV PLLHIALLVL
     FVIIIYAIIG LELFIGKMHK SCFLIGTDIL VEEDPAPCAF SGNGRQCSVN GTECKGSWVG
     PNGGITNFDN FAFAMLTVFQ CITMEGWTDV LYWMNDAMGF ELPWVYFVSL VIFGSFFVLN
     LVLGVLSGLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD
     WITQAEDIDP ENEEGDEEGK RNTSMPTSET ESVNTENVSG EGENPVCCGK LCQTISKSKF
     SRRWRRWNRF NRRRCRAAVK SVSFYWLVIV LVFLNTLTIS SEHYDQPNWL TQIQDIANKV
     LLALFTCEML IKMYSLGLQA YFVSLFNRFD CFVVCGGIVE TILVELEIMS PLGISVFRCV
     RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDET
     QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY
     ILLNVFLAIA VDNLADAESL NTAQKEEAEE KERKKNARKE SLENKKGDKS EGDQKKSKDS
     KVTIAEYGEG EDEDKDPYPP CDVPGEEEEE EEEEPEVPAG PRPRRISELN MKEKITPIPE
     GSAFFIFSST NPIRVGCHRL INHHIFTNLI LVFIMLSSIS LAAEDPIRSH SFRNNILGYF
     DYAFTAIFTV EILLKMTTFG AFLHKGSFCR NYFNLLDLLV VGVSLVSFGI QSSAISVVKI
     LRVLRVLRPL RAINRAKGLK HVVQCVFVAI RTIGNIMIVT TLLQFMFACI GVQLFKGKFY
     RCSDEAKQNP EECRGIYIVY KEGDVDNPVV RERVWQNSDF NFDNVLSAMM ALFTVSTFEG
     WPALLYKAID SNGENVGPIY NYRVEISIFF IIYIIIIAFF MMNIFVGFVI VTFQEQGEQE
     YKNCELDKNQ RQCVEYALKA RPLRRYIPKN PYQYKFWYVV NSTGFEYIMF VLIMLNTLCL
     AMQHYEQSKL FNDAMDILNM VFTGVFTVEM VLKVIAFKPK HYFTDAWNTF DALIVVGSVV
     DIAITEVNNS EDSARISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI
     AMLFFIYAVI GMQVFGKVAM RDNNQINRNN NFQTFPQAVL LLFRCATGEA WQEIMLACLP
     GKRCDPESDY NPGEEYTCGS NFAIIYFISF YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL
     GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP
     LNSDGTVMFN ATLFALVRTA LKIKTEGNLE QANEELRAVI KKIWKKTSMK LLDQVVPPAG
     DDEVTVGKFY ATFLIQDYFR KFKKRKEQGL VGKYPAKNTT IALQAGLRTL HDIGPEIRRA
     ISCDLQDDEP EENNQEEEED VYKRNGALFG NHINHVSSDR RDSFQQINTT HRPLHVQRPS
     IPSASDAEKN IYAHAGNSMF HNHHNHNSVG KQVPNSTNAN LNNANMSKVA NGKHPNVGNH
     EHRSENGYHS YSRVDHDKHR RSSSKRSESG DGHLPTICRE DHDVRDYCND DHYFGEPEYF
     SGEEYYEEDS MLSGNRHTSD YNYRYHCHDS DFERPKGYHH PHGFFEEDDS QICYDAKRSP
     RRRLLPPTPT PNRRSSFNFE CLRRQSSQDD ITLSPTFHHR TALPLHLMQQ QVMAVAGLDS
     SKAHKHSPSR STRSWATPPA TPPNRDRTPY YTPLIQVDRA ESTEHMNGSL PSLHRSSWYT
     DDPDISYRTF TPASLTVPND FRHKHSDKQR SADSLVEAVL ISEGLGRYAK DPKFVSATKH
     EIADACDMTI DEMESAASNL LNGNISSGTN GDMFPILSRQ DYELQDFGPG YSDEEPDTGR
     YEEDLADEMI CITTL
//
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