ID   A0A151MZ39_ALLMI        Unreviewed;       395 AA.
AC   A0A151MZ39;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN   Name=WNT5B {ECO:0000313|EMBL:KYO29782.1};
GN   ORFNames=Y1Q_0023150 {ECO:0000313|EMBL:KYO29782.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29782.1};
RN   [1] {ECO:0000313|EMBL:KYO29782.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29782.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC       ECO:0000256|RuleBase:RU003500}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO29782.1}.
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DR   EMBL; AKHW03004488; KYO29782.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151MZ39; -.
DR   STRING; 8496.A0A151MZ39; -.
DR   eggNOG; KOG3913; Eukaryota.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd19347; Wnt_Wnt5a; 1.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027:SF33; PROTEIN WNT-5A; 1.
DR   PANTHER; PTHR12027; WNT RELATED; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU003500};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW   ECO:0000256|RuleBase:RU003500}.
FT   TRANSMEM        35..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   395 AA;  44221 MW;  8E161145872AF4AA CRC64;
     MAEACAVREP RQRSIGILMQ RGALGTAGST MASKYLIVAL AIFSSFTQVV IEASSWWSLG
     MNPMNPMNPV QMPEVYIIGA QPLCSQLAGL SQGQKKLCQL YQDHMQFIGE GAKTGIKECQ
     YQFRHRRWNC STVDNNSVFG RVMQIGSRET AFTYAVSAAG VVNAMSRACR EGELSSCGCS
     RAARPKDLPR DWLWGGCGDN IEYGYRFAKE FVDARERERL YQRGSYESAR IMMNLHNNEA
     GRRTVYNLAD VACKCHGVSG SCSLKTCWLQ LADFRKVGDA LKEKYDSAAA MKLNTRGKLV
     QVNSRFNAPT IHDLIYIDPS PDYCVRNEST GSLGTQGRLC NKTSEGMDGC ELMCCGRGYD
     QFKTVQRERC HCKFHWCCYV KCKLCTEVVD QFVCK
//