ID A0A151N345_ALLMI Unreviewed; 1183 AA.
AC A0A151N345;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Caskin-2 isoform C {ECO:0000313|EMBL:KYO31147.1};
GN Name=CASKIN2 {ECO:0000313|EMBL:KYO31147.1};
GN ORFNames=Y1Q_0016493 {ECO:0000313|EMBL:KYO31147.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO31147.1};
RN [1] {ECO:0000313|EMBL:KYO31147.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO31147.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO31147.1}.
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DR EMBL; AKHW03004113; KYO31147.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151N345; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 49..81
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 82..114
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 115..147
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 189..221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 221..253
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 279..345
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 447..510
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 516..580
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 350..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 128055 MW; 1A181E0904F8C3DE CRC64;
MMGREQEMIQ AVKNGDVPGV QKLVAKVKAS KSKLLGSAKR LNVNYQDADG FSALHHAALG
GSLELISLLL EAQATVDIKD SNGMRPLHYA AWQGRVEPVR MLLRASATVN MASLDGQIPL
HLSAQYGHYE VSEMLLQHQS NPCLINKAKK TPLDLACEFG RLKVAQLLLN SHMCVALLEG
QSKDSSDPNY TTPLHLAAKN GHKEIIRQLL KAGIEINKQT KTGTALHEAA LYGKTEVVRL
LLEGGVDVNI RNTYNQTALD IVNQFTTSHA SKDIKQLLRG ILKVRALKDF WNLHDPTALN
IRAGDVITVL EQHADGRWKG HIHDAQKGTD RVGYFPPSIV EVISKRAAGD RNSVGSEGSI
GSIRSAGSGQ STEGTSGHST GLLIENAKPL PPGGEDLPQH LLGADPRNGQ PHSVLGPLGH
QNLANCTPSD RGFSHHYLRP EQLLEGKDAE AIYNWLSEFQ LESYTTNFLS AGYDVPTISR
MTPEDLTAIG VTKPGHRKKI STEIGQLSIA EWLPNYIPVD LMEWLSAIGL PQYHKKLVNN
GYDSITILTE LTWEDLQEIG INKLGHQKKI MLAVKKLRDL RKSLNQAEAN PATRKIPGTL
DIVTIESIEN GECQSPHTPK MITFQDSELS YELQTAMSNS CQETLTIKSS QGMSRSQESI
GPWQPGDQPN GDIFKHKKRS HSLNRYALSD GEHEDEDAPT STLGSYATLT RRPGRSQVPR
TCVQTNSKVS RSQSFAIRAK RKGPPPPPPK RLSSVSSAQA MEAESEQGPE TDRRPLSSPD
VVNPPNPDQS SMPRATLDDR ETGGARDACS SWLVASEWDG VEGNKPRRRT LSEPSVPLTE
ALQGSLEDVR SDTEEEPHAG GEEGGVSSSS SQNSSSECIP FAEEGNLTIK QRPKPTGQLR
ADAATPDSEP PCASPGMSPG AAREPEMPEF NLTESDTVKR RPRCREREPL QAVLKAFSLA
GQSEDLGSPC PQYAQAQAVS IMGPASPTPG TPPPPADALD DDSVEFRIAE IEKSILSLEK
GIRKRPVPLR AASPAEMHGA AVLRTPTTGA DASAKHTSVA STKLVFSGPK TTYQQVPQMP
RSTVAPWAAT NMALDAAVVP CPGTKGAGNS GEPMVAKPLD AAWAQQRLEQ TSSSLRAALQ
VAEKITAEEA DSHCGAEPLT KNILEDISNM FDDLADQLDA MLE
//
