ID A0A151N3J6_ALLMI Unreviewed; 1017 AA.
AC A0A151N3J6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE SubName: Full=Son of sevenless-like protein 1 isoform B {ECO:0000313|EMBL:KYO31338.1};
GN Name=SOS1-1 {ECO:0000313|EMBL:KYO31338.1};
GN ORFNames=Y1Q_0002573 {ECO:0000313|EMBL:KYO31338.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO31338.1};
RN [1] {ECO:0000313|EMBL:KYO31338.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO31338.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO31338.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03004091; KYO31338.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151N3J6; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 171..361
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 437..581
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 620..859
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 860..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..995
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 117831 MW; BDB26B539EC1D271 CRC64;
MEVQQQVHPN LSAKEDSLSY IEELILQLLN KLCIAQPRTV QDVEERVQKT FPHPIDKWAI
ADAQSAIEKR KRRNPLLLPA DKIHPLLKEV LGYKVDYHVS LYIVAVLEYI SADILKLAGN
YVFNIRHFEI SQQDIKVSMC ADKVLMDMFD QDDIGLVSLC EDEPSTSGEL NYYDLVRNEI
AEERQYLREL NLIIKVFREA FLSNKKLFTS YDIDMIFSNI SDIHELTVKL LGLIEDTVEM
TDESSPHPLA GSCFEDLAEE QAFDPYETLS QDILSPRFLE HFNNLMAKPA VALHFQSIAD
GFKEAVRYVL PRLMLIPVYH CLHYFELLQQ LQECSEEEED RECLKQAITA LLNLQCSMER
IYNKHSPRRR PGETMCRFYN RQVRSKHLAI KKMNEIQKNI DGWEGKDIGQ CCNEFIMEVA
DSEDNIVFED NLQSRNGIPI IKGGTVVKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL
LSLLIERFEI PEPEPTEADK LAIEKGEQPI SADLKRFRKE YVQPVQLRIL NVFRHWVEHH
FYDFERDLEL LDRLETFISS VRGKSMKKWV ESIAKIIKRK KIAQADGISH NITFESPLPP
IEWHICHVGQ PEMFDLMTLH PIEIARQLTL LEFDLYRAVQ PSELVGSVWT KEDKEINSPN
LLKMIRHTTN LTLWFEKCIV ETENFEERVA VLSRIIEILQ VFQDLNNFNG VLEIVSAMNS
VSVYRLDHTF EALQERKKKM LDEAVELSQD HFKKYLAKLK SINPPCVPFF GIYLTNILKT
EEGNPDFLKR QGKELINFSK RRKVAEITGE IQQYQNQPYC LRIEPEIRKF FENLNPMGNA
SEKEFTDYLF NKSLEIEPRN CRQPPKFPRK TTYTLKSPGI RPNTGRHGST SGTLRGHPTP
LEREPKFSVF LEPDLNSSCG SNSIFAPVFL PQSKSFFSSW SSLHKLSDEF LVPPPLPPRK
KFDQDTLNSK GGSKSDDDPP AIPPRQPPPP KIQPRVPAYN SSFDQPLSLL ENAETPQ
//