ID A0A151N5S2_ALLMI Unreviewed; 2837 AA.
AC A0A151N5S2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Neurofibromin isoform A {ECO:0000313|EMBL:KYO32158.1};
GN Name=NF1 {ECO:0000313|EMBL:KYO32158.1};
GN ORFNames=Y1Q_0007151 {ECO:0000313|EMBL:KYO32158.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO32158.1};
RN [1] {ECO:0000313|EMBL:KYO32158.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO32158.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO32158.1}.
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DR EMBL; AKHW03004004; KYO32158.1; -; Genomic_DNA.
DR RefSeq; XP_019348928.1; XM_019493383.1.
DR GeneID; 102564932; -.
DR CTD; 4763; -.
DR eggNOG; KOG1826; Eukaryota.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 1234..1450
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1579..1737
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2782..2837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2799..2826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2837 AA; 319713 MW; BD9C6DAC842456DA CRC64;
MAAHKPVEWV QAVVNRFDEQ LPIKAGQQNT HTRVSTEHNK ECLINISKYK FSLVISGLTN
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF
IHTFREGNQH AAELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED NADVHDIELL
QYISVDCAKL KRLLQETVFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQTPQT
DMADCAEKLF DLVDGFAEST KRKAAVWPLQ IILLVLCPEI IQDIAKDVVE ETKINKKLFL
DNLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP
SKPFSRGNQN ADVDLMIDCL VSCFRINPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN
SALDWWPKID AVYCHSVELR SMFSETLHKA IQGCGTHATI RMTPSLTLRE KMTSLKFKEK
PTDLETRSYK FLLLALVKLI HADPKLLLCN PRKQGPETQG STAELITGLV QLVPQSNMPE
IAQEAMEALL VLHQLDSIDL WNPDAPIETF WEISSQMLFY ICKKLTNHQI LSNTEILKWL
REILICRNKF LLKNKQSDRS SCHFLFLYGV GCDVSGGGAS QISLDHEEMV RCAPGASFRK
GKGNSSMEST AGCSGTSICR QAQTKLEVAL YMFLWSPDIE AVLVAMSCFR HLCEEADIRC
GVDEVSVHNF LPNYNTFMEF ASVSNMMSTG RAALQKRVMA LLRRIEHPTA GNTEAWEDTH
TKWEQATKLI LNFPKTKMED GQVTESLHKT IVKRRMSHVS GGGSIDLSDT DSLQEWINMT
GFLCALGGVC LQHRSNAGLA TYSPPMGPVN ERKGSMISMV STDGNTETPV SKFLDRLLSL
MVCNHEKVGL QIRTNIKDLV GLELSPALYP MLFNKLKNTI SKFFDSQGQV LLTETNTQFV
EQTIAIMKNL LDNHTEGSSE HLGQASIETM MLNLVRYVRV LGNLVHAIQI KTKLCQLVEV
MMERRDDLSF CQEMKFRNKM VEYLTDWVMG TSNQATDEDV KCLTRDLDQA SMEAVVSLLA
GLPLQPEEGD GVELMEAKSQ LFLKYFTLFM NLLNDCSEVE DESAQTGGRK RGMSRRLASL
RHCTVLAMSN LLNANVDSGL MHSIGLGYHK DLQTRATFME VLTKILQQGT EFDTLAETVL
ADRFERLVEL VTMMGDQGEL PIAMALANVV PCSQWDELAR VLVTLFDSRH LLYQLLWNMF
SKEVELADSM QTLFRGNSLA SKIMTFCFKV YGATYLQKLL EPLLRTVIMS PEWQHVSFEV
DPTRLEPTES LDDNQRSLLQ MTEKFFHAII NSSSEFPPQL RSVCHCLYQA TCHSLLNKAT
VKEKKENKKS VVSQRFPQNS IGAVGSAMFL RFINPAIVSP YEAGILDKKP PPRIERGLKL
MSKILQSIAN HVLFTKEEHM RPFNDFVKSN FDAARRFFLD IASDCPASDT VNHSLSFISD
GNVLALHRLL WNNQEKIGQY LSSNRDHKAV GRRPFDKMAT LLAYLGPPEH KPVADTHWSS
LNLTSSKFEE FMTRHQVHEK EEFKALKTLN IFYQAGTSKA GNPVFYYIAR RFKTGQINGD
LLIYHVLLTL KPYYAKPYEI VVDLTHAGPS NRFKTDFLSK WFVVFPGFAY ENVSAVFIYN
CNSWVREYTK YHERLLTGLK GSKRLIFIDS PGKLAEHIEH DQQKLPAATL ALEEDLKVFH
NALKLAHKDT KVSIKVGSTA VQVTSAERTR VLGQTVFLND IYYASEIEEI CLVDENQFTL
TIANQGTPLT FMHQECEAIV QSIIHIRTRW ELSQPDSIPQ HTKIRPKDVP GTLLNIALLN
LGSSDPSLRS AAYNLLCALT CTFNLKIEGQ LLETSGLCIP ANNTLFIVSI SKTLAANEPH
LTLEFLEECI SGFSKSSIEL KHLCLEYMTP WLSNLVRFCK HNDDAKRQRV TAILDKLITM
TINEKQMYPS IQAKIWGSLG QITDLLDVVL DSFIKTSATG GLGSIKAEVM ADTAVALASG
NVKLVSSKVI GRMCKIIDKT CLSPTPTLEQ HLMWDDIAIL ARYMLMLSFN NSLDVAAHLP
YLFHVVTLLV ATGPLSLRAS THGLVINIIH SLCTCSQLHF SEETKQVLRL SLTEFSLPKF
YLLFGISKVK SAAVIAFRSS YRDRSFSPGS YERETFALTS LETVTEALLE IMEACMRDIP
TCKWLDQWTE LAQKFAFQYN PSLQPRALVV FGCISKRVSH GQIKQIIRIL SKGLESCLKG
PDNYNSQVLI EATVIALTKL QPLLNKDSPM HKALFWVAMA VLQLDEVNLY SAGTALLEQN
LHTLDSLRVF NDKSPEEVFM EIRRPLEWHC KQMDHFVGLN FNSNFNFALV GHLLKGYRHP
SPMIVARTVR ILHTLLSLVN KHRNCDKFEV NTQSVAYLAA LLTVSEEVRS RCSLKHRKSL
LLTDVSMENV PMDTYPIHHS DTSCRTLKEN QPWSSPKGSD RHLAASYPTA GQISPRTRKS
MSLDMGQPSQ ANTKKLLGTR KSFDHLISDT KAPKRQEMES GTTTPPKMRR VAENDYEIET
QRISPQQHPH LRKVSVSESN VLLDEEVLTD PKIQALLLTV LATLVKYTTD EFDQRILYEY
LAEASVVFPK VFPVVHNLLD SKINTLLSLC QDPNLLNPIH GIVQSVVYHE ESPPQYQTSY
LQSFGFNGLW RFAGPFSKQT QIPDYAELIV KFLDALIDTY LPGIDEEVSE ESLLTPTSPY
PPAVQSQLSI TANLNLSNSM TSLATSQHSP GIDKENVELS PTTGHSNSGR TRHGSASQVQ
KQRSAGSFKR HSIKKIV
//
