ID A0A151N7L8_ALLMI Unreviewed; 1241 AA.
AC A0A151N7L8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=TDRD12 {ECO:0000313|EMBL:KYO32589.1};
GN ORFNames=Y1Q_0007782 {ECO:0000313|EMBL:KYO32589.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO32589.1};
RN [1] {ECO:0000313|EMBL:KYO32589.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO32589.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO32589.1}.
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DR EMBL; AKHW03003905; KYO32589.1; -; Genomic_DNA.
DR RefSeq; XP_019348414.1; XM_019492869.1.
DR AlphaFoldDB; A0A151N7L8; -.
DR STRING; 8496.A0A151N7L8; -.
DR GeneID; 102561428; -.
DR KEGG; amj:102561428; -.
DR CTD; 91646; -.
DR eggNOG; KOG0331; Eukaryota.
DR OrthoDB; 5351296at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd20434; Tudor_TDRD12_rpt1; 1.
DR CDD; cd20435; Tudor_TDRD12_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047390; Tudor_TDRD12_rpt1.
DR PANTHER; PTHR22655:SF2; ATP-DEPENDENT RNA HELICASE TDRD12-RELATED; 1.
DR PANTHER; PTHR22655; UNCHARACTERIZED; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00567; TUDOR; 2.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51203; CS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Helicase {ECO:0000313|EMBL:KYO32589.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 1102..1188
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
SQ SEQUENCE 1241 AA; 142047 MW; 1ECD4EEED5FBE995 CRC64;
MIEVLILKIE DPGCFWVILK GCGSFVDNEV EYRKLHADMN QFYNQSCRDV DEVMPLTLEE
GQVCVVFCQE LRCWCRAVIN TIMSCTDHCL VECFLVDYAK YIPVKTRDIR VAVEAFMRLP
YRARKFRLYC IKPVTLHIDF CEDTAEIVPA KIWDGAAIQY FQKLLRETTQ IEAKLCAIED
EHFDVYLYVT VQDEKVCVND ELVAKNFACY MSTEENTNNP ANKPSKQSPL SLVGFPEKVI
SPVLALWPVL LQGKAPKNLK TGPTQFELPD ISLSANSPGH TASNPLLEKN GKNLSTTSFN
GHNESTVGVF LGFPFKENIT ISGQTDSDLL EITCKKQLKE IQQDEKSGCV KLLQFLNPDP
LKTDHFQNEK QEFLKVSAEQ HFVVFNKKIE PCSSLETAPL LVDLKKELLW NKFRGPTFTE
SYCWPPIARG CDVVVISHHG NDPLLYVPPI LTFLQSRVCY KSLPNGNGPT TLIVCPGWKK
AQLVFELLKK YGRRSRQLHP MLLLVGLKNE EVKNMKFLQG CEVIVTTPYS LLRLLEHHSL
LLLRLCHLVL DEVEVLLSEA SKQVFMILDY YKKTIPVPGR ESAPRQIVVV GTHWNKHIEH
VTREFMNDPY IVITSVEEAC IYGNVQQVVE SNAIFCLKIH KEIEYHFKYV EEQWRKKFSP
GTHVVLVLTD DCMKYLGITD ATCVVHFSFP SSPSVFGTRL HSMADNFRSG IEKSSLKDDK
FTKAKSILLL TERNGCHAVG VLHYLEHTDA KIPPELSDFA AGVLKAKEDM KLARPLCRYL
KTLGVCKDMR ICPDRHQVNL QIDFPPKSSD QIRSTAGYVT ILPLHIVDAT NYFGRIVDKK
EDQYAILAVE MDKYFKKAGN KVSVEMAKKL SLYGLHEEKI FHRVQVLEIF PKEENGFFYN
VTIKYIDEGR TGQVRGHQLF PLPAEFQSLP PQAVEFIVCR VKPIDNETEW NPKITRYIHQ
KIKGKLHEAR VVLTLGNTVW VDPMVQVIRF PDLKISVNEY NIRSEILSMG MGTDNPEHIK
QLQKLCESAK MLAPEKKTLQ TFIRDTASPQ REPEQDMDSL QSPLLGEKLS ENCNFSQTIL
DHQSGAIAEI EAENSTQHHH KCFYPEIKWF QKEDTVTMKI KIRNVTDCKC EFLRNKVIFS
AFSEDKFYLV DTELYENILT EKSVCEIKNE EPVIILAKEK KESWLKLLKH KNPNVSFDFE
HWEDFGDESP FPVGAEKVHH PATLAMEEME ESSGSETESD D
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