GenomeNet

Database: UniProt
Entry: A0A151NA48_ALLMI
LinkDB: A0A151NA48_ALLMI
Original site: A0A151NA48_ALLMI 
ID   A0A151NA48_ALLMI        Unreviewed;       375 AA.
AC   A0A151NA48;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE            Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE   AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
GN   Name=MSTN {ECO:0000313|EMBL:KYO33708.1};
GN   ORFNames=Y1Q_0008837 {ECO:0000313|EMBL:KYO33708.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO33708.1};
RN   [1] {ECO:0000313|EMBL:KYO33708.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO33708.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC       growth. {ECO:0000256|RuleBase:RU369049}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC       ECO:0000256|RuleBase:RU369049}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU369049}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO33708.1}.
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DR   EMBL; AKHW03003682; KYO33708.1; -; Genomic_DNA.
DR   RefSeq; XP_006259980.1; XM_006259918.2.
DR   AlphaFoldDB; A0A151NA48; -.
DR   STRING; 8496.A0A151NA48; -.
DR   GeneID; 102566354; -.
DR   KEGG; amj:102566354; -.
DR   CTD; 2660; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   OrthoDB; 3015718at2759; -.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd19388; TGF_beta_GDF8; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF150; GROWTH/DIFFERENTIATION FACTOR 8; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685,
KW   ECO:0000256|RuleBase:RU369049};
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW   Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW   Signal {ECO:0000256|RuleBase:RU369049, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..375
FT                   /note="Growth/differentiation factor 8"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007585878"
FT   DOMAIN          263..375
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   375 AA;  42818 MW;  CCE42E4CDEE28453 CRC64;
     MQKLPICGYI YLFMLIILDP VDLNDSSQPK ENEEKDGLCN ACTWRQNTKS SRIEAIKIQI
     LSKLRLEQAP NISRDVIRQL LPKAPPLQEL IDLYDVQRDD SSEGSLEDDD YHATTETIIT
     MPTESDLLMQ MEGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVQKPTTVF VQILRLIKPM
     KDGTKYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAF DENGRDLAVT
     FPGPGEDGLN PFLEVRVSDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
     PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII
     YGKIPAMVVD HCGCS
//
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