ID A0A151NAM8_ALLMI Unreviewed; 809 AA.
AC A0A151NAM8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Insulin receptor substrate 1 isoform B {ECO:0000313|EMBL:KYO33864.1};
GN Name=IRS1 {ECO:0000313|EMBL:KYO33864.1};
GN ORFNames=Y1Q_0024492 {ECO:0000313|EMBL:KYO33864.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO33864.1};
RN [1] {ECO:0000313|EMBL:KYO33864.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO33864.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO33864.1}.
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DR EMBL; AKHW03003627; KYO33864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NAM8; -.
DR STRING; 8496.A0A151NAM8; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF11; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|EMBL:KYO33864.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 14..116
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 157..261
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 259..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 87064 MW; 120F96749B23AD41 CRC64;
MASPTEGGEG CFSDVRKVGY LRKPKSMHKR FFVLRAASES GPARLEYYEN EKKWRHKSGA
PKRSIPLESC FNINKRADSK NKHLVALYTK DEHFAIAADS EPEQESWYQA LLQLHNRAKG
HHHHHHHHSD VAFGGTGAGL GEAGEDSYGE AVPGPAFKEV WQVILKPKGL GQTKNLIGIY
RLCLTNKTIS FVKLNSDAAA VVLQLLNIRR CGHSENFFFI EVGRSAVTGP GEFWMQVDDS
VVAQNMHETI LEAMRAMSEE FRPRSKSQSS SNCSNPISVP LRSRHHVNNP PPSQVGLSRR
SRTESVTATS PAGGGGGAGG KPSSFRVRAS SDGEGTMSRP ASVDGSPVSP STNRTHSHRH
RGSSRLHPPL NHSRSIPMPS SRCSPSATSP VSLSSSSTSG HGSTSDCLFP RRSSASVSGS
PSDGGFISSD EYGSSPCDFR SSFRSVTPDS LGHTPPARGD EELNNYICMG GKSASSCCSL
AAPNGHFVPR PCHPQQQQSR YPGTPCCSRA GGEEGADLEK GFRKRTHSAG TSPTISHQKT
PSQSSAASIE EYTEMLPSYP CGGSRLPSYR HSAFVPTHSY PEECLEMHHL DSSHHRTNSA
PHTDDGYMPM SPGVAPVPSV GGNPKGGDYM PMSPKSVSAP QQIINPGRGG RHPQAMVDSN
GYMMMSPSGS YSPDGGPAGY GKIWTNGASH HPKLSVESNE GKLPCGGSDY INMSPASGST
TSTPPDCYFA SSGPPVAGQE PERRMMTYTT SAYPSYLAGH NELMCPPLCH ALVWGFAALL
GWSDRSLALV LDFHAQIWLS GRNRRIEKC
//
