ID A0A151NBX5_ALLMI Unreviewed; 1301 AA.
AC A0A151NBX5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=G-protein coupled receptor 124 {ECO:0000313|EMBL:KYO34291.1};
GN Name=ADGRA2 {ECO:0000313|EMBL:KYO34291.1};
GN ORFNames=Y1Q_0018167 {ECO:0000313|EMBL:KYO34291.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34291.1};
RN [1] {ECO:0000313|EMBL:KYO34291.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34291.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO34291.1}.
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DR EMBL; AKHW03003560; KYO34291.1; -; Genomic_DNA.
DR RefSeq; XP_006258454.2; XM_006258392.3.
DR STRING; 8496.A0A151NBX5; -.
DR GeneID; 102573624; -.
DR KEGG; amj:102573624; -.
DR CTD; 25960; -.
DR eggNOG; KOG0619; Eukaryota.
DR OrthoDB; 2900279at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KYO34291.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1301
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585920"
FT TRANSMEM 748..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 863..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 982..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 231..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 315..410
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 745..1036
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1113..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1167
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1301 AA; 143105 MW; 611785018B914425 CRC64;
MPGPGVRVLV LAVVPVLVLA LPGAAACPVP VRACKCAGER PKALGIPGAA RRRVVCSGQD
LPHPPDASLL PNATATLLLS NNKITVLKNG SFFGLRALEK LDLKNNLINT IQPGAFLGLS
ELKRLDLSNN RIGCLSTGVF LGLINLMRLN VSGNIFSTLQ PGVFDELPSL KLIDFATEYL
TCDCNLRWVL PWAQNRSAQI SDKTLCIYPR HLHAKPLRST REGQLRCAGA PELHTHHLIP
SLRQVVFQGD RLPFQCTATY LDNSTQILWY HNQVLVEEDE QTGIILEQSL IHDCTFITSE
LILSNIHVSA NGEWECAVST AQGNVSKKVE IVVLETSASY CPAERVTNNR GDFRWPRTLA
GITAYQSCLQ YPFTSVAVSG GPTAEKQSSR RCDRTGRWEE GDYSNCLYTN DITRVLYTFV
LMPINASNAL TLAHQLRVYT AEAANFSDMM DVIYVAQMIE KFIGYVDQIK QLTDVIVEMA
SNMMLVDDHI LWMAQIEDKA CTSIVHSVEK IAGYTLSSNA QHMAVNSRNI AFEAYLIKPE
SFMGLSCTAF QKREGRRVLL PERGAEPLAD QQLQFRCTTG RPNISLASFH IKNSIALASI
QLPPSLFSPW APLPPPVDCK LQFLAFRNGK LFCSTGNSSR LADDGKRRSV ATPVIYAGTH
GCGASNLTDP VTVSLRHFGE GADPVAAYWN FEVLGGYGGW SVEGCQLARQ EPNITTLHCR
HMNNFAVLME LNTFPSEAQG TPEVLHPVIY TCTAILLLCL FTTIITYIIN HSTIHISRKC
WHMLLNLCFH IAMTSAVFAG GITLTNYLIV CQAVGIILHY SSLSTLLWMA VKARVIYKEV
TWKAPQPQDG DVSQPAPRPM LRFYLIAGGI PLIICGITAA VNIHNYRDNN PYCWLVWRPS
LGAFYVPVAF ILLVTWIYFL CAGIKLQCQS KIQKDPPEPL ETAPRLGGSS NLLTDSGSLS
VTLNTGMPSP DVDSVYSLKV QFWALAITHS LYIALWTFGA MAVSQRWYLN IIFSCLYGVT
AVALGLFIFV HHCARRQDVL NSWFACCPSY RNALPMQAYV HPGMPVEDGS QVFIGCNPEV
AHSIKSSSSP SSTNSTVGHC KLTNLQVAQS QAESCAPRPA SYEEPEPANN KNASVARYSN
NMHGRRNHKS RAKQYREGKH HRLKALRGPA HDHLSSESGS LHNSHSESYH SSRNSPLNNS
CPGAQAGAGQ EGEAALTQSD GSDGSGSHQV PDFDRAQRRS TSRDNLKQAN TMEKETKRRS
YPLNVANQNG GLKGSKYDIN LTSAESMAGM KTGLWKSETT V
//
