ID A0A151NCL5_ALLMI Unreviewed; 1202 AA.
AC A0A151NCL5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRC {ECO:0000313|EMBL:KYO34552.1};
GN ORFNames=Y1Q_0012418 {ECO:0000313|EMBL:KYO34552.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34552.1};
RN [1] {ECO:0000313|EMBL:KYO34552.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34552.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO34552.1}.
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DR EMBL; AKHW03003392; KYO34552.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NCL5; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd14558; R-PTP-C-2; 1.
DR CDD; cd14557; R-PTPc-C-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF539; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KYO34552.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1202
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585941"
FT TRANSMEM 475..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 295..390
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 551..810
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 730..801
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 842..1126
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1033..1117
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 31..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 136095 MW; 577351A65668FB72 CRC64;
MFLWLKLLAF VFALLEKDVF VKAGETDKGS VNATFHNITS PSPTHLSPTH SKSSSPASII
EGQAEMSTTP NYSNPSPLHA STLPSTTLTP SSNSTNISQS SADISHSMAT TASSLTIAPT
PTNVSEVDCG KKIASVGPYK YLKDSVKATL NISGLILKNC FCKPECNIAN SSSIENLTEC
QEYNIYLEFK DGCNRNLSFS VPPNTKENEL EVQDTTNISV TLKWTKNFQE NCHLTYTYGC
ESGNHSSAGD DQSKEPNKIV TELLPYHNYT CTSKIIFAGE RIETHTKEIQ TDVGVPGIPE
NVTQVVTSEN VSITWRGPSN IAGPIGGYIV TCKKGKSVFL NKENHTHTCT GYEPYNEYTI
TVRAYTKNKK NETVKGEEQA CKGHTTSAEP LIQSSKLEFL SNNEVKIQCV SKANGPEEKF
ILTWEGKNET KDSCIFIKKG LSYLTSYDFE ILAKNRDFYG NRLYKTVTTK YNSKALIIFL
AFLIIVTSIA LLLVLYKIYN LHKDSLRSSS EDVGLVRVKD DEKQLLNIEP IPAELLLENY
KRKIADEGRL FLDEFQSIPR IFSKFSVKEA RKNCNQNKNR YIDILPYDYN RVELSEIMGE
PGSDYINASY IDGFKEPRKY IAAQGPKDET TDDFWRMIWE QKATIIVMVT RCEEGNRNKC
AQYWPSMEDD TATFGDIVVK INEIKTCPDY IIQKLNITNR KEKTSGRDIT HIQFTSWPDH
GVPEDPHLLL KLRRRVNALS NFFSGPIVIH CSAGVGRTGT YIGIDAMLEG LDAEGRVDVY
GYVVKLRRQR CLMVQVEAQY ILIHQALVEY NQFGETEVPL LELHTYLNNL KRRDQPNEPS
LLEAEFQRLP TYKGWRTQNT GNRGENRSKN RNSKVIPYDF NRVPIKHEEE KSKESEHDSD
ESSDEDSESE EASRYINASF ISGYWGPRAM IATQAPMQET INDFWQMVFQ RKVKVIVMLT
ELKEGDQELC ARYWGEQKQT YDGIDVEMKD ISQSSSYTIR VFDVTQVKRK ETQTVYHYQY
HNWNGMNVPE NPKDLISMAL NLRKKLPDKP VTEDNRYSRS VPIVIHCRDG SQQTGMFCAL
LTLVESAEIE EVIDVFQVVK SLRRSRLGMV TSFEHYQFLY DSVATIYPPQ NGQVKKNSKQ
EDKVAFDNEV DKADQEANLV AIDLTSVTPE ARKDSEACED SKFADCIKGT ESSTNGPTTP
VL
//
