ID A0A151NDW1_ALLMI Unreviewed; 618 AA.
AC A0A151NDW1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Glyoxylate reductase/hydroxypyruvate reductase {ECO:0000313|EMBL:KYO34984.1};
GN Name=GRHPR {ECO:0000313|EMBL:KYO34984.1};
GN ORFNames=Y1Q_0000902 {ECO:0000313|EMBL:KYO34984.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34984.1};
RN [1] {ECO:0000313|EMBL:KYO34984.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34984.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO34984.1}.
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DR EMBL; AKHW03003207; KYO34984.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NDW1; -.
DR STRING; 8496.A0A151NDW1; -.
DR eggNOG; KOG0069; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF230; GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE B; 1.
DR Pfam; PF00389; 2-Hacid_dh; 2.
DR Pfam; PF02826; 2-Hacid_dh_C; 2.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:KYO34984.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 3..304
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 97..276
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT DOMAIN 312..615
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 406..585
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 618 AA; 66649 MW; 680CB4B934225931 CRC64;
MKILHQSRLC HIEQWDSEDP VPRSELLKKV AGIQGLYCLL TEKIDAEVLD AAGPSLKVVS
TMSVGYDHIS LQELKKRGIK LGYTPDVLTE AVAELTVALL LATSRRLLEA AEKAKTGGWG
TWKPLWMCGH GLTDSTVGIL GLGRIGVAVA TRLKPFGVKR FLYTDMSARP EVATSIPADS
VTMDELARLS DFIVVCCALT PETQGICNKS LFSQMKDTAI FVNTSRGGVV NQDDLYQALV
NGQIAAAGLD VTEPEPLPTD HPLFKLKNCV VLPHIASATV STRNAMAALA ANNLLAGLRG
EAMEKEHQGC SSALEHTRCS IEQWDSDEPI PQSELLARVA GKHGLLCLLS DRIDKEVLDA
AGSNLKVIST MSAGFDHLAL EEIKKRGIRV GYIPDILTDA TAELTVALLL ATCRRLPESV
EEVKNGGWTT WKPFWMCGYG LSDSTVGIIG LGRIGQAVAR RLKPFGVKRF LYAGRHPKPE
GAAEFEAEFV PLTRLAEESD FVVVTCSLTP DTAGLCNKDF FGKMKKTSVF INTSRGAVVN
QDDLYQALVS GQIAAAGLDV TTPEPLPTEH PLLSLKNCVI LPHIGSATYA TRSTMSVLAV
NNLLAGLKGE SMPSELHL
//
