ID A0A151NF63_ALLMI Unreviewed; 1294 AA.
AC A0A151NF63;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger protein 516 isoform B {ECO:0000313|EMBL:KYO35390.1};
GN Name=ZNF516 {ECO:0000313|EMBL:KYO35390.1};
GN ORFNames=Y1Q_0007976 {ECO:0000313|EMBL:KYO35390.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO35390.1};
RN [1] {ECO:0000313|EMBL:KYO35390.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO35390.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO35390.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03003201; KYO35390.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF3; ZINC FINGER PROTEIN 516; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 151..178
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 179..201
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 279..307
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 352..379
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 380..407
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 439..466
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 632..659
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1229..1252
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 568..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1294 AA; 143646 MW; E8E9E0F21B4637C1 CRC64;
MRSVCFCEGF QERSVWTHGA LEGAHGFTFR FLFVWVPSLK CCYLKRTRCS VLSAYETHTY
PLTTQSFLRH QKEDLSTENE ERKLTWQNCM IENAVRLSAI GQVLVLLPCL TDVVAVVQMD
RNREAEMELR RSSSPGKMNK SDVDGDKVMC HSCCICGKSF PFQSSLSQHM RKHTGEKPYK
CPYCDHRASQ KGNLKIHIRS HRTGTLSQGH EVEMGEAQLG EMGVSEGLDG CTSPTKSTSA
CNKIVNGATQ TDNGKILLRS SKKEVADSTP AEDGKLPIYQ CTFCKNKFER KKDLEQHIHQ
VHKPFKCRLC NYMTLREETL LNHIEKDHII AQVPNGEAYT ENCKSELSAG EFPCEVCGQA
FSQTWFLKAH MKKHRGSFDH GCHICGRRFK EPWFLKNHMK AHGPKTGSKN KPKNDLELIA
TINDVIQEET IVTGLSLYEV CTKCGNLFTN MESLKAHNAV HYKAQRSSIE DKAESLIDGN
LDPSVTKQFF LQCLNLRPSV GTDRVTRGQL GKRVAELDPV NSYQAWHLAT KGKVAEPSEY
IKYVGWDEVL ADADVTYDKD KREYILVNQE KRKRDQDSPS SSSNPKKKSC ASGRLEKNSG
VQSGENCIIS PGDLDYKPSS KQSRRASQNK STECFECGKI FRTYHQMVLH SRVHRKERRS
CSESGMATQP DRYGSSSEEG DSGSVTGPST PGSASAPEDS VTSGMGEEGA EDSSEEGLPE
PSLGGKSYHC NLSQGQTPMM TSQVDEVPQL GSYNARESDA NESKAEIPAL ISALENKIKE
PFPEYEDQRC SPGLKMPAFR QSQEPPCSSS IADLASGRGQ TPSDMVTDLK TSVEMQASHS
KENLPCREHP MVEKGAEAQE MVLLDLSEKS TRDDLCNKGF TSSLQAALIV HPCPFCNHKT
YYPEVLWMHK RILHKVSCNS MVPPWVQQNG FKSIKNNMVF LARNGRTGPP PVLGGKECHP
LPIARFTRTQ VPSALPGSKS NSFPVGMSTK PGNMHQSKDS HSFGHCGPRS SGLDGYRLAK
LNNTQEQYSI AAQQSQLKSK YDVNSKLMQA GSFNRSLTPT QTVIYRPNTQ PANSKQVEKY
VVPQGNAGFT SSGKHCASDS LKAKFNPPSQ YHPLCKTEQY SKHEEPSVPQ QESHTKAGNE
MRTLANCTTG ARASPLMHSQ LSAAGASPGL HSNKQESASD DHEKRLDILN IFKTYIPKDL
ASLYQTWGAN SPALDHAGMF RTQTRQGDCV CIECGKCFNQ PSHLRTHLRS HTVVFESNGL
RGTEVHTTSA DAPKQGRDHS NADIVHTVPL RKGT
//
